SC23A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC23A_MOUSE
• UniProt AC: Q01405
• Protein Name: Protein transport protein Sec23A {ECO:0000305}
• Gene Name: Sec23a {ECO:0000312|MGI:MGI:1349635}
• Organism: Mus musculus (Mouse).
• Sequence Length: 765
• Subcellular Localization: Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Enriched at endoplasmic reticulum exit sites.
• Protein Description: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex..
• Protein Sequence: MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVLCSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPTYAGISELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCIEDEDLQALKESMQMSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKVPVTQATRGPQVQQPPPSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIEKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTKDIHGQFKMGFGGTLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNAPIPQGGRGAVQFVTQYQHSSGQRRIRVTTIARNWADAQTQIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDPNSFRFSETFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSSAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTTYLEFIQ ------CCCHHHHHH	24.93	-
46	Ubiquitination	AALFTPLKERPDLPP HHHHCCCCCCCCCCC	53.53	-
74	S-palmitoylation	RAVLNPLCQVDYRAK HHHHCCCCCCHHHHH	3.80	28526873
81	Acetylation	CQVDYRAKLWACNFC CCCHHHHHHHHHHHH	35.25	22826441
85	S-palmitoylation	YRAKLWACNFCYQRN HHHHHHHHHHHHHCC	2.44	28680068
150	Phosphorylation	DLQALKESMQMSLSL HHHHHHHHHHHHHHH	16.84	25266776
180	S-nitrosylation	VQVHELGCEGISKSY EEEEECCCCCCCHHH	7.28	22178444
180	Glutathionylation	VQVHELGCEGISKSY EEEEECCCCCCCHHH	7.28	24333276
185	Acetylation	LGCEGISKSYVFRGT CCCCCCCHHHEECCC	43.83	22826441
187	Phosphorylation	CEGISKSYVFRGTKD CCCCCHHHEECCCCC	13.82	24719451
198	Ubiquitination	GTKDLSAKQLQEMLG CCCCCCHHHHHHHHC	48.44	22790023
208	Ubiquitination	QEMLGLSKVPVTQAT HHHHCCCCCCCCCCC	56.45	22790023
307	Ubiquitination	MVVGDELKTPIRSWH CCCCCCCCCCCCCHH	50.65	22790023
308	Phosphorylation	VVGDELKTPIRSWHD CCCCCCCCCCCCHHH	36.25	19060867
312	Phosphorylation	ELKTPIRSWHDIEKD CCCCCCCCHHHHHCC	29.49	22324799
318	Acetylation	RSWHDIEKDNAKYVK CCHHHHHCCCHHEEC	57.53	23954790
318	Ubiquitination	RSWHDIEKDNAKYVK CCHHHHHCCCHHEEC	57.53	22790023
322	Malonylation	DIEKDNAKYVKKGTK HHHCCCHHEECHHHH	57.75	26320211
329	Acetylation	KYVKKGTKHFEALAN HEECHHHHHHHHHHH	55.77	22826441
392	Acetylation	TFQRVFTKDIHGQFK HHHHHHCHHCCCCEE	43.13	22826441
392	Ubiquitination	TFQRVFTKDIHGQFK HHHHHHCHHCCCCEE	43.13	22790023
556	Ubiquitination	QLIRLCQKFGEYHKD HHHHHHHHHCHHCCC	55.10	22790023
562	Acetylation	QKFGEYHKDDPNSFR HHHCHHCCCCCCCCC	64.03	23954790
575	Phosphorylation	FRFSETFSLYPQFMF CCCCCHHCCCCHHHH	34.12	29895711
577	Phosphorylation	FSETFSLYPQFMFHL CCCHHCCCCHHHHHC	8.19	29895711
639	Phosphorylation	PEPVLLDSSSILADR CCCEEECCHHHHHHH	26.42	29899451
640	Phosphorylation	EPVLLDSSSILADRI CCEEECCHHHHHHHH	22.51	29899451
641	Phosphorylation	PVLLDSSSILADRIL CEEECCHHHHHHHHH	26.10	29899451
669	Ubiquitination	ETIAQWRKSGYQDMP HHHHHHHHCCCCCCH	45.32	22790023
670	Phosphorylation	TIAQWRKSGYQDMPE HHHHHHHCCCCCCHH	33.87	25338131
713	Phosphorylation	IDTEHGGSQARFLLS EECCCCCHHHHHHHH	25.84	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC23A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC23A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC23A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SC23A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.