VPS11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS11_MOUSE
• UniProt AC: Q91W86
• Protein Name: Vacuolar protein sorting-associated protein 11 homolog
• Gene Name: Vps11
• Organism: Mus musculus (Mouse).
• Sequence Length: 941
• Subcellular Localization: Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle . Early endosome . Cytoplasmic vesicle, autophagosome . Cytoplasmic vesicle, clathrin-coated
• Protein Description: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (By similarity)..
• Protein Sequence: MAAYLQWRRFVFFEKELVKEPLGNDGAAPGAAPVSGSAASKFLCLPPGITVCDSGRGSLVFGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASVGEDEEGINPLVKIWNLEKRDGGNPLCTRIFPAIPGTEPTVVSCLTVHENLNFMAIGFTDGSVTLNKGDITRDRHSKTQILHKGNYPVTGLAFRQAGKTTHLFVVTTENVQSYIVSGKDYPRVELDTHGCGLRCSALSDPSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIVHWFRGYLVIVSRDRKVSPKSEFTSRDSQNSDKQILNIYDLCNKFIAYSAGFEDIVDVLAEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDSDGLAQIFMQYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLANADHTTLLLNCYTKLKDSSKLEEFIKTKSESEVHFDVETAIKVLRQAGYYSHALYLAENHAHHEWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKTLMHHIPEQTTQLLKGLCTDYRPSLEGRGDREALSCRASSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEKDPQAKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQHEQYRQVIAVCERHGEQEPSLWEQALSYFARKEEDCKEYVAAVLRHIENKSLMPPLLVVQTLAHNSTATLSIIRDYLVQKLQKQSQQIAQDELRVRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDADCPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLKCSNDSFSVIADYFGRGVFNKLTLLTDPPTARLTPSLEAGLQRDLLMHSRRGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAYLQWRR ------CCHHHHHHH	12.57	-
200	Phosphorylation	AFRQAGKTTHLFVVT EEEECCCEEEEEEEE	20.66	26745281
201	Phosphorylation	FRQAGKTTHLFVVTT EEECCCEEEEEEEEC	21.77	26745281
207	Phosphorylation	TTHLFVVTTENVQSY EEEEEEEECCCEEEE	24.08	26745281
208	Phosphorylation	THLFVVTTENVQSYI EEEEEEECCCEEEEE	17.60	26745281
213	Phosphorylation	VTTENVQSYIVSGKD EECCCEEEEECCCCC	16.73	26745281
214	Phosphorylation	TTENVQSYIVSGKDY ECCCEEEEECCCCCC	6.56	26745281
303	Phosphorylation	SEFTSRDSQNSDKQI CCCCCCCCCCCCHHH	30.10	30387612
417	Ubiquitination	QYIRTIGKLEPSYVI HHHHHHCCCCCHHHH	45.91	22790023
460	S-palmitoylation	HTTLLLNCYTKLKDS CHHHHHHHHHHHCCC	4.62	28680068
469	Ubiquitination	TKLKDSSKLEEFIKT HHHCCCHHHHHHHHC	64.96	22790023
475	Ubiquitination	SKLEEFIKTKSESEV HHHHHHHHCCCCCCC	56.04	22790023
535	Ubiquitination	EALRYIGKLPFEQAE HHHHHHCCCCHHHHH	43.35	22790023
589	Phosphorylation	EALSCRASSEEFIPI HHHHCCCCCCCCCHH	20.94	-
590	Phosphorylation	ALSCRASSEEFIPIF HHHCCCCCCCCCHHH	39.91	-
781	Ubiquitination	YLVQKLQKQSQQIAQ HHHHHHHHHHHHHHH	63.45	22790023
813	Phosphorylation	EIQELKASPKIFQKT HHHHHHCCCCHHHHC	25.74	26824392
894	Phosphorylation	QLKCSNDSFSVIADY HHHCCCCCCHHHHHH	24.54	21454597
901	Phosphorylation	SFSVIADYFGRGVFN CCHHHHHHHCCCCCC	10.02	21454597
904	Methylation	VIADYFGRGVFNKLT HHHHHHCCCCCCHHE	28.36	24129315
918	Phosphorylation	TLLTDPPTARLTPSL EEECCCCCCCCCCCH	29.78	23984901
922	Phosphorylation	DPPTARLTPSLEAGL CCCCCCCCCCHHHHH	12.79	27180971
924	Phosphorylation	PTARLTPSLEAGLQR CCCCCCCCHHHHHHH	33.34	28066266
937	Phosphorylation	QRDLLMHSRRGT--- HHHHHHHHCCCC---	15.09	29176673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS11_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS11_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS11_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPE39_HUMAN	VIPAS39	physical	19109425
VP33B_HUMAN	VPS33B	physical	19109425
STX1A_MOUSE	Stx1a	physical	14623309
STX6_MOUSE	Stx6	physical	14623309
STX8_MOUSE	Stx8	physical	14623309
VPS45_MOUSE	Vps45	physical	14623309

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.