RNC_MOUSE - dbPTM
RNC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RNC_MOUSE
UniProt AC Q5HZJ0
Protein Name Ribonuclease 3
Gene Name Drosha
Organism Mus musculus (Mouse).
Sequence Length 1373
Subcellular Localization Nucleus . Nucleus, nucleolus . A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies.
Protein Description Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies..
Protein Sequence MQGNTCHRMSYHPGRGCPRGRGGHGARPSAPAFRPQNLRLLHPQQPPAQYQYEPPSAPSSSYSNSQAPSFMPPRPDFVPYPPPAAPSAQGPLPPCPVRPPYPNHQMRHPFPVPPCFPPMPPPMPCPNNPPASGAPPGQGTFPFMVPPPSMPHPPPPPVMPQQVNYQYPPGYSHSFPPPGFNSYQNNSSSFPPSANSSSTPHFRHLPPYSLPKAQNERRSPERLKHYDDHRHRDHSHGRGERHRSLERRERGRSPERRRPESRYRSDYDRGRTPPPRHRSYERSRERDRERHRHREARRSPSLERSYKKEYKRSGRSYALPVAPEPAGCTPELPGEMIKTTESWAPPPENVNHRSPSREKKRARWEEEKDRWSDSQGSGKEKNYTSIKEKEAEEVPPEKTEEEEEELLKPVWIRCTHSESYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGNRQEKAKAARPPWEPPKTKLDEDLESSSESECETDDDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPEVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDKTKRPVALRTKTLADLLESFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIERKYRQELKEMRWEREHQEREPEEAEDIKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
219PhosphorylationKAQNERRSPERLKHY
HHHCCCCCHHHHCCC		37.0225266776
235PhosphorylationDHRHRDHSHGRGERH
CCCCCCCCCCCCHHH		31.7425266776
253PhosphorylationERRERGRSPERRRPE
HHHHCCCCCCCCCCC		33.6625266776
272PhosphorylationSDYDRGRTPPPRHRS
CCCCCCCCCCCCCHH		42.8623970565
279PhosphorylationTPPPRHRSYERSRER
CCCCCCHHHHHHHHH		25.8125338131
283PhosphorylationRHRSYERSRERDRER
CCHHHHHHHHHHHHH		26.9325338131
299PhosphorylationRHREARRSPSLERSY
HHHHHHHCHHHHHHH		17.1826824392
301PhosphorylationREARRSPSLERSYKK
HHHHHCHHHHHHHHH		44.0725159016
305PhosphorylationRSPSLERSYKKEYKR
HCHHHHHHHHHHHHH		31.7422942356
329PhosphorylationAPEPAGCTPELPGEM
CCCCCCCCCCCCCCC		20.9122006019
342PhosphorylationEMIKTTESWAPPPEN
CCEEECCCCCCCCCC		26.8428285833
354PhosphorylationPENVNHRSPSREKKR
CCCCCCCCCCHHHHH		21.4823684622
356PhosphorylationNVNHRSPSREKKRAR
CCCCCCCCHHHHHHH		55.0825159016
372PhosphorylationEEEKDRWSDSQGSGK
HHHHHHCCCCCCCCC		28.4225266776
374PhosphorylationEKDRWSDSQGSGKEK
HHHHCCCCCCCCCCC		30.8128285833
377PhosphorylationRWSDSQGSGKEKNYT
HCCCCCCCCCCCCCC		38.7725266776
704PhosphorylationSMHQILLYLLRCSKA
CHHHHHHHHHHHHCC		10.5525338131
709PhosphorylationLLYLLRCSKALVPEE
HHHHHHHHCCCCCHH		17.9625338131
806PhosphorylationLRHLLANSPKVKQTD
HHHHHHCCCCCCHHH		22.0828066266
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RNC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RNC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RNC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PGH2_HUMANPTGS2physical
25963660
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RNC_MOUSE

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Related Literatures of Post-Translational Modification

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