DHB11_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHB11_MOUSE
• UniProt AC: Q9EQ06
• Protein Name: Estradiol 17-beta-dehydrogenase 11
• Gene Name: Hsd17b11
• Organism: Mus musculus (Mouse).
• Sequence Length: 298
• Subcellular Localization: Secreted . Cytoplasm. According to PubMed:12697717 it is cytoplasmic. However, the relevance of such result remains unclear.
• Protein Description: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione..
• Protein Sequence: MKYLLDLILLLPLLIVFSIESLVKLFIPKKKKSVAGEIVLITGAGHGIGRLTAYEFAKLNTKLVLWDINKNGIEETAAKCRKLGAQAHPFVVDCSQREEIYSAAKKVKEEVGDVSILVNNAGVVYTADLFATQDPQIEKTFEVNVLAHFWTTKAFLPVMMKNNHGHIVTVASAAGHTVVPFLLAYCSSKFAAVGFHRALTDELAALGRTGVRTSCLCPNFINTGFIKNPSTNLGPTLEPEEVVEHLMHGILTEKQMIFVPSSIALLTVLERIVPERFLQVLKHRINVKFDAVVGYKDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Acetylation	LVKLFIPKKKKSVAG HHHHHCCCCCCCCCC	72.85	15616809
30	Acetylation	VKLFIPKKKKSVAGE HHHHCCCCCCCCCCE	61.14	15616817
58	Acetylation	LTAYEFAKLNTKLVL HHHHHHHHCCCEEEE	47.82	23954790
58	Ubiquitination	LTAYEFAKLNTKLVL HHHHHHHHCCCEEEE	47.82	-
62	Ubiquitination	EFAKLNTKLVLWDIN HHHHCCCEEEEEECC	35.21	-
70	Acetylation	LVLWDINKNGIEETA EEEEECCCCCHHHHH	57.81	23954790
70	Ubiquitination	LVLWDINKNGIEETA EEEEECCCCCHHHHH	57.81	27667366
79	Malonylation	GIEETAAKCRKLGAQ CHHHHHHHHHHHCCC	31.91	26320211
82	Ubiquitination	ETAAKCRKLGAQAHP HHHHHHHHHCCCCCC	61.82	-
82	Malonylation	ETAAKCRKLGAQAHP HHHHHHHHHCCCCCC	61.82	26320211
94	S-palmitoylation	AHPFVVDCSQREEIY CCCEEEECHHHHHHH	2.23	28526873
105	Malonylation	EEIYSAAKKVKEEVG HHHHHHHHHHHHHHC	58.79	26320211
105	Ubiquitination	EEIYSAAKKVKEEVG HHHHHHHHHHHHHHC	58.79	27667366
105	Acetylation	EEIYSAAKKVKEEVG HHHHHHHHHHHHHHC	58.79	15618583
296	Ubiquitination	FDAVVGYKDK----- EEEEEECCCC-----	53.78	27667366
296	Succinylation	FDAVVGYKDK----- EEEEEECCCC-----	53.78	23954790
298	Acetylation	AVVGYKDK------- EEEECCCC-------	59.07	2374479

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHB11_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHB11_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHB11_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DHB11_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.