AEBP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AEBP2_MOUSE
• UniProt AC: Q9Z248
• Protein Name: Zinc finger protein AEBP2
• Gene Name: Aebp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 504
• Subcellular Localization: Nucleus .
• Protein Description: May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3 (By similarity). DNA-binding transcriptional repressor..
• Protein Sequence: MAAALADMADLEELSRLSPLSPGSPGPAARGRAEPPEEEEEEDDEEAEAEAVAALLLNGGAGGGAGGGEAETMSEPSPESASQAGGDEDEDEEDDEDEGSSSGGAEEESSAESLVGSSSGGCSGDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGGPGGPGSSGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTLMDIDSTISSGRSTPAMMNGQGSTTASSKHIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEESGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRFDILNFPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAALADMA ------CHHHHHCHH	11.05	-
15	Phosphorylation	MADLEELSRLSPLSP HHCHHHHHCCCCCCC	34.16	26643407
18	Phosphorylation	LEELSRLSPLSPGSP HHHHHCCCCCCCCCC	23.76	26824392
21	Phosphorylation	LSRLSPLSPGSPGPA HHCCCCCCCCCCCCC	30.51	26824392
24	Phosphorylation	LSPLSPGSPGPAARG CCCCCCCCCCCCCCC	30.02	26824392
129	Phosphorylation	CSGDETRSLSPGAAS CCCCCCCCCCCCCCC	40.39	27149854
131	Phosphorylation	GDETRSLSPGAASSS CCCCCCCCCCCCCCC	23.64	25521595
136	Phosphorylation	SLSPGAASSSSGDGD CCCCCCCCCCCCCCC	30.16	25619855
137	Phosphorylation	LSPGAASSSSGDGDG CCCCCCCCCCCCCCC	24.64	25619855
138	Phosphorylation	SPGAASSSSGDGDGK CCCCCCCCCCCCCCC	35.53	25619855
139	Phosphorylation	PGAASSSSGDGDGKE CCCCCCCCCCCCCCC	42.74	25619855
199	Phosphorylation	TSGGRRGSLEMSSDG CCCCCCCCEEECCCC	21.24	27087446
203	Phosphorylation	RRGSLEMSSDGEPLS CCCCEEECCCCCCCC	18.85	25168779
204	Phosphorylation	RGSLEMSSDGEPLSR CCCEEECCCCCCCCC	48.61	6449291
210	Phosphorylation	SSDGEPLSRMDSEDS CCCCCCCCCCCCCCC	35.95	25619855
214	Phosphorylation	EPLSRMDSEDSISST CCCCCCCCCCCHHHH	33.68	63817055
217	Phosphorylation	SRMDSEDSISSTLMD CCCCCCCCHHHHHHH	21.96	28507225
231	Phosphorylation	DIDSTISSGRSTPAM HHHHHHCCCCCCCCC	34.08	55992491
234	Phosphorylation	STISSGRSTPAMMNG HHHCCCCCCCCCCCC	42.12	25263469
235	Phosphorylation	TISSGRSTPAMMNGQ HHCCCCCCCCCCCCC	17.44	25263469
314	Phosphorylation	WLQRHMLTHSGDKPF HHHHHCCCCCCCCCE	13.35	20047950
316	Phosphorylation	QRHMLTHSGDKPFKC HHHCCCCCCCCCEEE	43.37	20047950
364	Phosphorylation	QPKAKEESPSKAGMN CCCCCCCCCCHHCHH	35.25	67171567
366	Phosphorylation	KAKEESPSKAGMNKR CCCCCCCCHHCHHHH	44.40	28059163
383	Phosphorylation	LKNKRRRSLPRPHDF HHHHHHHCCCCCCCC	40.70	26824392
395	Phosphorylation	HDFFDAQTLDAIRHR CCCCCHHHHHHHHHH	28.46	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AEBP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AEBP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AEBP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AEBP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.