| UniProt ID | PSMD5_MOUSE | |
|---|---|---|
| UniProt AC | Q8BJY1 | |
| Protein Name | 26S proteasome non-ATPase regulatory subunit 5 | |
| Gene Name | Psmd5 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 504 | |
| Subcellular Localization | ||
| Protein Description | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity).. | |
| Protein Sequence | MAAQAVSLLREVARLEAPLEELRALQSVVQAVPLHELREQAAELRLRPLFSLLNQNNREQTALCVSILERLLQAVEPIHLARNLRLDLQRGLTHPDDSVKTLTLSQIGRIVENSEAVTEILNNAELLKQIVYCIGGENLSVAKAAIKSLSRISLTQAGLEALFESNLLDDLKNVMKTNDVVRYRVYELIIDISSVSSESLNYCTTSGLVTQLLKELTGEDVLVRATCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSGFYLPGFVKFFGNLAVMDSPQQICERYPVFLEKVFEMADSQDPTMIGVAVDTVGILGSSVEGKQVLQKTGTRFERVLMRVGYQAKNASTELKIRCLDAVSSLLYLSPEQQTDDFLGMTESWFSSMSRDSLELFRGISNQPFPELHCAALKVFTAIADQPWAQRLMFNSPGFVEFVMDRSVEHDKASKDAKYELVKALANSKTVAEIFGNSNYLRLRAYLSEGPYYVKPVATTAVEGAD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAAQAVSLL ------CHHHHHHHH | 14.31 | - | |
| 27 | Phosphorylation | EELRALQSVVQAVPL HHHHHHHHHHHHCCH | 25.71 | 27180971 | |
| 101 | Phosphorylation | HPDDSVKTLTLSQIG CCCCCCCEEEHHHHH | 23.87 | - | |
| 105 | Phosphorylation | SVKTLTLSQIGRIVE CCCEEEHHHHHHHHC | 17.95 | - | |
| 122 | Ubiquitination | EAVTEILNNAELLKQ HHHHHHHHCHHHHHH | 51.86 | 27667366 | |
| 143 | Ubiquitination | GENLSVAKAAIKSLS CCCHHHHHHHHHHHH | 35.87 | 22790023 | |
| 147 | Ubiquitination | SVAKAAIKSLSRISL HHHHHHHHHHHCCCC | 40.39 | 22790023 | |
| 176 | Ubiquitination | DDLKNVMKTNDVVRY HHHHHHHHHCHHHHH | 39.63 | 27667366 | |
| 177 | Ubiquitination | DLKNVMKTNDVVRYR HHHHHHHHCHHHHHE | 20.68 | 27667366 | |
| 193 | Phosphorylation | YELIIDISSVSSESL EEEEEEHHHCCCCCC | 22.42 | - | |
| 351 | Malonylation | MRVGYQAKNASTELK HHHCCCCCCCCCHHH | 37.21 | 26320211 | |
| 351 | Ubiquitination | MRVGYQAKNASTELK HHHCCCCCCCCCHHH | 37.21 | 27667366 | |
| 384 | Phosphorylation | TDDFLGMTESWFSSM CCCCCCCCHHHHHHC | 25.68 | - | |
| 389 | Phosphorylation | GMTESWFSSMSRDSL CCCHHHHHHCCHHHH | 20.90 | - | |
| 457 | Phosphorylation | KASKDAKYELVKALA CCCHHHHHHHHHHHH | 19.06 | 20139300 | |
| 466 | Phosphorylation | LVKALANSKTVAEIF HHHHHHCCCHHHHHH | 24.89 | 20139300 | |
| 467 | Ubiquitination | VKALANSKTVAEIFG HHHHHCCCHHHHHHC | 46.99 | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PSMD5_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PSMD5_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PSMD5_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PSMD5_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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