BMP2K_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BMP2K_MOUSE
• UniProt AC: Q91Z96
• Protein Name: BMP-2-inducible protein kinase
• Gene Name: Bmp2k
• Organism: Mus musculus (Mouse).
• Sequence Length: 1138
• Subcellular Localization: Nucleus.
• Protein Description: May be involved in osteoblast differentiation..
• Protein Sequence: MKKFSRMPKSEGSGGGAAAGGAAGGGLGGGFASSSMGVRVFAVGRYQVTLEESLAEGGFSTVFLVRTHSGIRCALKRMYVNNTPDLNICKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGSFTIPDNSRYSHNVHCLIRFMLEPDPECRPDIFQVSYFAFKFAKKDCPVSNINNSFLPSTLPEPMTATEAAARKSQMKARITDTIGPTETSIAPRQRPKANSTAATSSVLTIQSSATPVKVPAPGEFSNHKPKGALRPGNGSEVLMVQGPPQQPPQQHRVLQQLQQGDWRLQQLHLHRHPHHHHQQQQQQQQQQQQQQLQQQQQQQQQLLQNAYLQQYQHAMHQQHILQQQFLMHSVYQPQPPASQYPAMMQQYQQAFLQQQMLARHQQPAQQVSPEYLTSPQEFSPALVSYASSLPAQVGTIVDSSYGANRSVAEKEAVANFTNQKTISHPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLGASTPSDKTVDLPPAPHSRPPEEPFASVPFISHSGSPEKKTTEHSPNQKSITANLTKNGGSSPLCKDQRAGKKTSENPVIRGQVQKGHDDSESDFESDPPSPKSSEEEQEDEDAQGEHGDFNDDDTEPENLGHRPLLMDSEDEEEDDKHSSDSECEQAKTKRGDTSSLRRDKPGVAPDTALLTPARSPADALTPSQEFDVFGAVPFFAAPAPQSLQHRGDGKNLSQHAFPEQEDFDVFTKAPFNKKVSVQDWPAVGPDARPLPARPRSVDIFGSTPFQPFSVSASKSESKEDVFGLVPFEEITGSQQQQKVKQRSLQKLSSRQRRTKQDVSKSNGKRHHGTPTSAKKTLKPPYRTPERARRHKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRASVLPSDESLLDPFGAKPFHPPDLWHQPHQGLSDICVDHTTILPGRPRQNSVHGSFHSAETLRMDDFGAVPFTELVVQSVTPQQSQPVELDPFGAAPFPSKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KFSRMPKSEGSGGGA CCCCCCCCCCCCCCC	41.12	25619855
13	Phosphorylation	RMPKSEGSGGGAAAG CCCCCCCCCCCCCCC	30.16	25619855
375	Phosphorylation	RQRPKANSTAATSSV CCCCCCCCCCCCCCE	25.04	26643407
376	Phosphorylation	QRPKANSTAATSSVL CCCCCCCCCCCCCEE	21.81	26643407
379	Phosphorylation	KANSTAATSSVLTIQ CCCCCCCCCCEEEEE	21.04	26643407
380	Phosphorylation	ANSTAATSSVLTIQS CCCCCCCCCEEEEEC	17.45	26643407
381	Phosphorylation	NSTAATSSVLTIQSS CCCCCCCCEEEEECC	19.45	26643407
603	Phosphorylation	FTNQKTISHPPDMSG CCCCCCCCCCCCCCC	34.86	25338131
643	Phosphorylation	RSNRLGASTPSDKTV HHCCCCCCCCCCCCC	38.77	26745281
644	Phosphorylation	SNRLGASTPSDKTVD HCCCCCCCCCCCCCC	26.69	25521595
646	Phosphorylation	RLGASTPSDKTVDLP CCCCCCCCCCCCCCC	52.40	26745281
667	Phosphorylation	PPEEPFASVPFISHS CCCCCCCCCCCCCCC	30.60	26643407
672	Phosphorylation	FASVPFISHSGSPEK CCCCCCCCCCCCCCC	16.39	26643407
674	Phosphorylation	SVPFISHSGSPEKKT CCCCCCCCCCCCCCC	33.89	26643407
676	Phosphorylation	PFISHSGSPEKKTTE CCCCCCCCCCCCCCC	32.66	26643407
685	Phosphorylation	EKKTTEHSPNQKSIT CCCCCCCCCCCCEEE	21.22	21454597
690	Phosphorylation	EHSPNQKSITANLTK CCCCCCCEEEEEEEC	18.53	29514104
701	Phosphorylation	NLTKNGGSSPLCKDQ EEECCCCCCCCCCCC	30.13	26745281
702	Phosphorylation	LTKNGGSSPLCKDQR EECCCCCCCCCCCCC	25.76	25521595
714	Phosphorylation	DQRAGKKTSENPVIR CCCCCCCCCCCCCCC	44.77	25266776
715	Phosphorylation	QRAGKKTSENPVIRG CCCCCCCCCCCCCCC	44.23	26824392
731	Phosphorylation	VQKGHDDSESDFESD CCCCCCCCCCCCCCC	45.09	26525534
733	Phosphorylation	KGHDDSESDFESDPP CCCCCCCCCCCCCCC	52.10	26643407
737	Phosphorylation	DSESDFESDPPSPKS CCCCCCCCCCCCCCC	56.25	25195567
741	Phosphorylation	DFESDPPSPKSSEEE CCCCCCCCCCCCHHH	50.80	25195567
805	Phosphorylation	AKTKRGDTSSLRRDK HHHHCCCCHHHCCCC	24.04	29472430
806	Phosphorylation	KTKRGDTSSLRRDKP HHHCCCCHHHCCCCC	31.92	30635358
807	Phosphorylation	TKRGDTSSLRRDKPG HHCCCCHHHCCCCCC	28.17	25266776
819	Phosphorylation	KPGVAPDTALLTPAR CCCCCCCCCCCCCCC	20.39	-
823	Phosphorylation	APDTALLTPARSPAD CCCCCCCCCCCCHHH	18.76	28066266
827	Phosphorylation	ALLTPARSPADALTP CCCCCCCCHHHCCCC	26.92	25293948
833	Phosphorylation	RSPADALTPSQEFDV CCHHHCCCCCCCCCC	23.71	26239621
835	Phosphorylation	PADALTPSQEFDVFG HHHCCCCCCCCCCCC	36.79	25293948
865	Phosphorylation	RGDGKNLSQHAFPEQ CCCCCCHHHCCCCCC	29.34	30352176
879	Phosphorylation	QEDFDVFTKAPFNKK CCCCCEECCCCCCCC	26.58	23140645
888	Phosphorylation	APFNKKVSVQDWPAV CCCCCCCCCCCCCCC	23.96	23684622
908	Phosphorylation	PLPARPRSVDIFGST CCCCCCCCEECCCCC	27.16	26824392
914	Phosphorylation	RSVDIFGSTPFQPFS CCEECCCCCCCCCCE	23.35	25159016
915	Phosphorylation	SVDIFGSTPFQPFSV CEECCCCCCCCCCEE	28.62	25159016
921	Phosphorylation	STPFQPFSVSASKSE CCCCCCCEEECCCCC	23.11	26239621
923	Phosphorylation	PFQPFSVSASKSESK CCCCCEEECCCCCCC	26.15	25159016
925	Phosphorylation	QPFSVSASKSESKED CCCEEECCCCCCCCC	29.25	25159016
927	Phosphorylation	FSVSASKSESKEDVF CEEECCCCCCCCCCC	44.61	27087446
929	Phosphorylation	VSASKSESKEDVFGL EECCCCCCCCCCCEE	48.73	27087446
943	Phosphorylation	LVPFEEITGSQQQQK EEEHHHCCCCHHHHH	33.78	25619855
945	Phosphorylation	PFEEITGSQQQQKVK EHHHCCCCHHHHHHH	19.03	23984901
955	Phosphorylation	QQKVKQRSLQKLSSR HHHHHHHHHHHHHHH	32.43	26745281
960	Phosphorylation	QRSLQKLSSRQRRTK HHHHHHHHHHHHHHH	30.43	24453211
961	Phosphorylation	RSLQKLSSRQRRTKQ HHHHHHHHHHHHHHH	42.75	26745281
981	Phosphorylation	NGKRHHGTPTSAKKT CCCCCCCCCCCCCCC	21.02	25266776
983	Phosphorylation	KRHHGTPTSAKKTLK CCCCCCCCCCCCCCC	40.95	29472430
984	Phosphorylation	RHHGTPTSAKKTLKP CCCCCCCCCCCCCCC	39.02	29472430
993	Phosphorylation	KKTLKPPYRTPERAR CCCCCCCCCCHHHHH	35.33	26643407
995	Phosphorylation	TLKPPYRTPERARRH CCCCCCCCHHHHHHH	24.53	25266776
1010	Phosphorylation	KKVGRRDSQSSNEFL CCCCCCCCCCCCCCE	30.10	25521595
1012	Phosphorylation	VGRRDSQSSNEFLTI CCCCCCCCCCCCEEE	38.80	27087446
1013	Phosphorylation	GRRDSQSSNEFLTIS CCCCCCCCCCCEEEE	32.51	27087446
1018	Phosphorylation	QSSNEFLTISDSKEN CCCCCCEEEECCCCC	24.61	25619855
1020	Phosphorylation	SNEFLTISDSKENIS CCCCEEEECCCCCEE	30.51	25619855
1022	Phosphorylation	EFLTISDSKENISVA CCEEEECCCCCEEEE	34.77	25619855
1027	Phosphorylation	SDSKENISVALTDGK ECCCCCEEEEECCCC	16.96	25338131
1038	Phosphorylation	TDGKDRASVLPSDES CCCCCCHHCCCCCHH	25.69	25266776
1042	Phosphorylation	DRASVLPSDESLLDP CCHHCCCCCHHHCCC	50.26	23984901
1045	Phosphorylation	SVLPSDESLLDPFGA HCCCCCHHHCCCCCC	38.94	23984901
1087	Phosphorylation	PGRPRQNSVHGSFHS CCCCCCCCCCCCCCC	13.73	26824392
1091	Phosphorylation	RQNSVHGSFHSAETL CCCCCCCCCCCCCCC	12.61	25159016
1094	Phosphorylation	SVHGSFHSAETLRMD CCCCCCCCCCCCCCC	26.28	26060331
1121	Phosphorylation	QSVTPQQSQPVELDP EECCCCCCCCCCCCC	31.07	23649490

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BMP2K_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BMP2K_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BMP2K_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BMP2K_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1010; SER-1012 ANDSER-1013, AND MASS SPECTROMETRY.
PubMed: 19144319

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1010; SER-1012 ANDSER-1013, AND MASS SPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1010 AND SER-1013, ANDMASS SPECTROMETRY.
PubMed: 17242355