PSMG2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMG2_MOUSE
• UniProt AC: Q9EST4
• Protein Name: Proteasome assembly chaperone 2
• Gene Name: Psmg2 {ECO:0000312|MGI:MGI:1922901}
• Organism: Mus musculus (Mouse).
• Sequence Length: 264
• Subcellular Localization: Nucleus .
• Protein Description: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity)..
• Protein Sequence: MFVPCGESVPDLTNFTLLMPAVSVGNVGQLAIDLIISTLNMCKIGYFYTDCLVPMVGNNPYATEEENSNELSINTEVYSLPSKKLVVLQLRSIFIKYKSKSFCEKLLAWVESSGCARIIVLSSSHSYHRNDAQLRSTPFRYLLTPCLQKSVQNKIKSLNWLEMEKSRCIPEMSDSEFCIRIPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDAVSLVEYLNEWLQIIKPCNDGPMASALPWKIPSSWRLLFGSGLPPALF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	LSINTEVYSLPSKKL CCCCEEEEECCCCCE	9.77	23737553
79	Phosphorylation	SINTEVYSLPSKKLV CCCEEEEECCCCCEE	38.69	23737553
82	Phosphorylation	TEVYSLPSKKLVVLQ EEEEECCCCCEEEEE	47.95	23737553
137	Phosphorylation	NDAQLRSTPFRYLLT CCHHHCCCHHHHHHH	21.73	-
146	S-palmitoylation	FRYLLTPCLQKSVQN HHHHHHHHHHHHHHH	5.46	28526873
149	Ubiquitination	LLTPCLQKSVQNKIK HHHHHHHHHHHHHHH	39.38	22790023
165	Ubiquitination	LNWLEMEKSRCIPEM CCHHHHHHHCCCCCC	41.72	22790023
188	Ubiquitination	IPGGGITKTLYDESC ECCCCHHCEECCCCC	34.31	22790023
188	Acetylation	IPGGGITKTLYDESC ECCCCHHCEECCCCC	34.31	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMG2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMG2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMG2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PSMG2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.