ARP2_MOUSE - dbPTM
ARP2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARP2_MOUSE
UniProt AC P61161
Protein Name Actin-related protein 2
Gene Name Actr2
Organism Mus musculus (Mouse).
Sequence Length 394
Subcellular Localization Cytoplasm, cytoskeleton . Cell projection .
Protein Description Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity)..
Protein Sequence MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDSQGRKV
-------CCCCCCEE		11.46-
7Ubiquitination-MDSQGRKVVVCDNG
-CCCCCCEEEEECCC		46.3222790023
11S-nitrosocysteineQGRKVVVCDNGTGFV
CCCEEEEECCCCCEE		1.96-
11S-nitrosylationQGRKVVVCDNGTGFV
CCCEEEEECCCCCEE		1.9621278135
11GlutathionylationQGRKVVVCDNGTGFV
CCCEEEEECCCCCEE		1.9624333276
46SuccinylationPIIRSTTKVGNIEIK
CEEECCCEECCEEEE		48.5123806337
46UbiquitinationPIIRSTTKVGNIEIK
CEEECCCEECCEEEE		48.51-
46AcetylationPIIRSTTKVGNIEIK
CEEECCCEECCEEEE		48.5123806337
53UbiquitinationKVGNIEIKDLMVGDE
EECCEEEEEEECCCH		31.8322790023
72PhosphorylationRSMLEVNYPMENGIV
HHHHHCCCCCCCCCC		14.77-
86AcetylationVRNWDDMKHLWDYTF
CCCHHHCHHHHHHCC		42.4123954790
91PhosphorylationDMKHLWDYTFGPEKL
HCHHHHHHCCCHHHC		7.7422817900
97AcetylationDYTFGPEKLNIDTRN
HHCCCHHHCCCCCCC		50.3923954790
97UbiquitinationDYTFGPEKLNIDTRN
HHCCCHHHCCCCCCC		50.3922790023
110PhosphorylationRNCKILLTEPPMNPT
CCCEEEEECCCCCCC		42.8922817900
117PhosphorylationTEPPMNPTKNREKIV
ECCCCCCCCCHHHHH		35.6327180971
118UbiquitinationEPPMNPTKNREKIVE
CCCCCCCCCHHHHHH		56.0922790023
195AcetylationDITRYLIKLLLLRGY
HHHHHHHHHHHHHCC		30.4122826441
202PhosphorylationKLLLLRGYAFNHSAD
HHHHHHCCCCCCCCC		11.1129899451
207PhosphorylationRGYAFNHSADFETVR
HCCCCCCCCCHHHHH		30.5529899451
219UbiquitinationTVRMIKEKLCYVGYN
HHHHHHHHHHCCCCC		38.5622790023
219AcetylationTVRMIKEKLCYVGYN
HHHHHHHHHHCCCCC		38.5622826441
221S-nitrosylationRMIKEKLCYVGYNIE
HHHHHHHHCCCCCCH		3.7121278135
221S-nitrosocysteineRMIKEKLCYVGYNIE
HHHHHHHHCCCCCCH		3.71-
221GlutathionylationRMIKEKLCYVGYNIE
HHHHHHHHCCCCCCH		3.7124333276
237PhosphorylationEQKLALETTVLVESY
HHHHHHEEEEEEEEE		24.05-
238PhosphorylationQKLALETTVLVESYT
HHHHHEEEEEEEEEE		11.49-
299MalonylationDTRSEFYKHIVLSGG
CCHHHHHHHHEECCC		31.9826320211
299AcetylationDTRSEFYKHIVLSGG
CCHHHHHHHHEECCC		31.9822826441
299UbiquitinationDTRSEFYKHIVLSGG
CCHHHHHHHHEECCC		31.98-
322MalonylationSRLERELKQLYLERV
HHHHHHHHHHHHHHH		33.2426320211
322AcetylationSRLERELKQLYLERV
HHHHHHHHHHHHHHH		33.2422826441
331MalonylationLYLERVLKGDVEKLS
HHHHHHHCCCHHHHH		50.6526320211
336MalonylationVLKGDVEKLSKFKIR
HHCCCHHHHHCCEEE		58.8926320211
368AcetylationLADIMKDKDNFWMTR
HHHHHHCCCCCEECH		49.4023806337
368UbiquitinationLADIMKDKDNFWMTR
HHHHHHCCCCCEECH		49.4022790023
388AcetylationKGVRVLEKLGVTVR-
HCCHHHHHHCCCCC-		46.5122826441
388UbiquitinationKGVRVLEKLGVTVR-
HCCHHHHHHCCCCC-		46.5122790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARP2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARP2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARP2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ARP2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARP2_MOUSE

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Related Literatures of Post-Translational Modification

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