S61A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S61A1_MOUSE
• UniProt AC: P61620
• Protein Name: Protein transport protein Sec61 subunit alpha isoform 1
• Gene Name: Sec61a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 476
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Localizes exclusively in granular structures in the endoplasmic reticulum (ER).
• Protein Description: Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. [PubMed: 27392076]
• Protein Sequence: MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Acetylation	IKFLEVIKPFCVILP HHHHHHHHHHEEECC	36.90	22826441
13	S-nitrosocysteine	LEVIKPFCVILPEIQ HHHHHHHEEECCCCC	2.23	-
13	S-palmitoylation	LEVIKPFCVILPEIQ HHHHHHHEEECCCCC	2.23	28526873
13	S-nitrosylation	LEVIKPFCVILPEIQ HHHHHHHEEECCCCC	2.23	22178444
13	Glutathionylation	LEVIKPFCVILPEIQ HHHHHHHEEECCCCC	2.23	24333276
107	Acetylation	IEVGDTPKDRALFNG EEECCCHHHHHHHCH	63.04	23954790
107	Succinylation	IEVGDTPKDRALFNG EEECCCHHHHHHHCH	63.04	23954790
107	Malonylation	IEVGDTPKDRALFNG EEECCCHHHHHHHCH	63.04	26320211
287	Phosphorylation	PIKLFYTSNIPIILQ CEEEEEECCCCHHHH	22.76	-
295	Phosphorylation	NIPIILQSALVSNLY CCCHHHHHHHHHHHH	21.81	-
392	Ubiquitination	SSAKDVAKQLKEQQM CCHHHHHHHHHHHHH	56.88	22790023
392	Acetylation	SSAKDVAKQLKEQQM CCHHHHHHHHHHHHH	56.88	2393157
395	Malonylation	KDVAKQLKEQQMVMR HHHHHHHHHHHHHHH	51.49	26320211
395	Ubiquitination	KDVAKQLKEQQMVMR HHHHHHHHHHHHHHH	51.49	27667366
407	Phosphorylation	VMRGHRETSMVHELN HHHCCHHHHHHHHHH	23.29	28833060
408	Phosphorylation	MRGHRETSMVHELNR HHCCHHHHHHHHHHH	17.66	26824392
466	Phosphorylation	EIFVKEQSEVGSMGA HHHCHHHCCCCCCCH	35.03	28066266
470	Phosphorylation	KEQSEVGSMGALLF- HHHCCCCCCCHHCC-	21.15	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S61A1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S61A1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S61A1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HYOU1_MOUSE	Hyou1	physical	24218449
CHIP_MOUSE	Stub1	physical	24218449
TERA_MOUSE	Vcp	physical	24218449
PSN1_MOUSE	Psen1	physical	20541250

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.