dbPTM

PSN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PSN1_MOUSE
UniProt AC	P49769
Protein Name	Presenilin-1
Gene Name	Psen1
Organism	Mus musculus (Mouse).
Sequence Length	467
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Golgi apparatus membrane Multi-pass membrane protein . Cytoplasmic granule . Cell membrane . Cytoplasmic vesicle . Translocates with bound NOTCH1 from the endoplasmic reticulum and/or G
Protein Description	Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity (By similarity). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. [PubMed: 10421573]
Protein Sequence	MTEIPAPLSYFQNAQMSEDSHSSSAIRSQNDSQERQQQHDRQRLDNPEPISNGRPQSNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVIMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYVTVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVPKNPKYNTQRAERETQDSGSGNDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSGSILTSEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	AIRSQNDSQERQQQH HHHCCCCHHHHHHHH	41.30	25266776
51	Phosphorylation	LDNPEPISNGRPQSN CCCCCCCCCCCCCCC	43.90	25367039
57	Phosphorylation	ISNGRPQSNSRQVVE CCCCCCCCCCCCCCC	39.18	25266776
59	Phosphorylation	NGRPQSNSRQVVEQD CCCCCCCCCCCCCCC	29.36	25266776
324	Phosphorylation	TQRAERETQDSGSGN HHHHHHHCCCCCCCC	43.85	27087446
327	Phosphorylation	AERETQDSGSGNDDG HHHHCCCCCCCCCCC	25.66	25521595
329	Phosphorylation	RETQDSGSGNDDGGF HHCCCCCCCCCCCCC	38.07	25521595
337	Phosphorylation	GNDDGGFSEEWEAQR CCCCCCCCHHHHHHC	37.57	25619855
346	Phosphorylation	EWEAQRDSHLGPHRS HHHHHCCCCCCCCCC	23.85	29472430
353	Phosphorylation	SHLGPHRSTPESRAA CCCCCCCCCHHHHHH	45.33	25266776
354	Phosphorylation	HLGPHRSTPESRAAV CCCCCCCCHHHHHHH	30.91	25266776
357	Phosphorylation	PHRSTPESRAAVQEL CCCCCHHHHHHHHHH	28.55	29472430
365	Phosphorylation	RAAVQELSGSILTSE HHHHHHHCCCCCCCC	29.73	26824392
367	Phosphorylation	AVQELSGSILTSEDP HHHHHCCCCCCCCCH	15.85	27087446
370	Phosphorylation	ELSGSILTSEDPEER HHCCCCCCCCCHHHH	28.53	27087446
371	Phosphorylation	LSGSILTSEDPEERG HCCCCCCCCCHHHHC	36.24	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
346	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
346	S	Phosphorylation		-
Phosphorylation on Ser-346 inhibits endoproteolysis.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PSN1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_MOUSE	Ctnnb1	physical	11104755
NICA_MOUSE	Ncstn	physical	15474363
PSN1_MOUSE	Psen1	physical	15474363
PEN2_MOUSE	Psenen	physical	15474363
APH1A_MOUSE	Aph1a	physical	15474363
CADH1_MOUSE	Cdh1	physical	11953314
NOTC1_MOUSE	Notch1	physical	11518718
NOTC2_MOUSE	Notch2	physical	11518718
NOTC3_MOUSE	Notch3	physical	11518718
NOTC4_MOUSE	Notch4	physical	11518718
GSK3B_MOUSE	Gsk3b	physical	12805290
DLL1_MOUSE	Dll1	physical	12794186
P85A_MOUSE	Pik3r1	physical	15192701
NMDZ1_MOUSE	Grin1	physical	15066262
NMDE1_MOUSE	Grin2a	physical	15066262
NICA_MOUSE	Ncstn	physical	11943765
ERLN2_MOUSE	Erlin2	physical	22771797
VPP1_MOUSE	Atp6v0a1	physical	20541250
CADH2_MOUSE	Cdh2	physical	20696212
CTNB1_MOUSE	Ctnnb1	physical	20696212

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PSN1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; SER-367; THR-370AND SER-371, AND MASS SPECTROMETRY.	19144319 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367; THR-370 ANDSER-371, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-370, AND MASSSPECTROMETRY.	15345747 [Abstract]

show