VPP1_MOUSE - dbPTM
VPP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPP1_MOUSE
UniProt AC Q9Z1G4
Protein Name V-type proton ATPase 116 kDa subunit a isoform 1
Gene Name Atp6v0a1
Organism Mus musculus (Mouse).
Sequence Length 839
Subcellular Localization Cytoplasmic vesicle membrane
Multi-pass membrane protein. Melanosome. Coated vesicle.
Protein Description Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity)..
Protein Sequence MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEAELHHQQMADPDLLEESSSLLEPNEMGRGAPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTHGFQNIVDAYGIGTYREINPAPYTVITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKHENEMFSMVFSGRYIILLMGLFSIYTGLIYNDCFSKSLNIFGSSWSVRPMFTQGNWTEETLLGSSVLQLNPAIPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMSSLFGYLVILIFYKWTAYDAHSSRNAPSLLIHFINMFLFSYPESGNAMLYSGQKGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDAEEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLHVRSLAGGLGLFFIFAAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYTGTGFKFLPFSFEHIREGKFDE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50UbiquitinationDVNVFQRKFVNEVRR
CCCHHHHHHHHHHHH		42.7722790023
74UbiquitinationFVEKEIRKANIPIMD
HHHHHHHHCCCCCCC		51.9922790023
103UbiquitinationDLEANFEKIENELKE
CHHHHHHHHHHHHHH		51.7022790023
119AcetylationNTNQEALKRNFLELT
CCCHHHHHHHHHHHH		52.95160817
119UbiquitinationNTNQEALKRNFLELT
CCCHHHHHHHHHHHH		52.9522790023
126PhosphorylationKRNFLELTELKFILR
HHHHHHHHHHHHHHH		29.8721659604
151 (in isoform 2)Phosphorylation-31.7229899451
151 (in isoform 3)Phosphorylation-31.7229899451
152 (in isoform 3)Phosphorylation-25.3125338131
152 (in isoform 2)Phosphorylation-25.3125338131
153 (in isoform 3)Phosphorylation-65.5229899451
153 (in isoform 2)Phosphorylation-65.5229899451
158PhosphorylationDPDLLEESSSLLEPN
CHHHHHHHHCCCCCC		18.8225338131
159PhosphorylationPDLLEESSSLLEPNE
HHHHHHHHCCCCCCC		28.4325338131
221PhosphorylationEDPVTGDYVHKSVFI
CCCCCCCCCCCEEEE		13.0529899451
242UbiquitinationQLKNRVKKICEGFRA
HHHHHHHHHHHHHHH		50.1322790023
254S-nitrosylationFRASLYPCPETPQER
HHHHHCCCCCCHHHH		2.7622588120
257PhosphorylationSLYPCPETPQERKEM
HHCCCCCCHHHHHHH		18.5329899451
262UbiquitinationPETPQERKEMASGVN
CCCHHHHHHHHHCCC		51.6022790023
295UbiquitinationRVLQAAAKNIRVWFI
HHHHHHHHHCCEEEE		48.4522790023
353PhosphorylationRGTEHSGSTVPSILN
CCCCCCCCCHHHHHH		29.28-
362OxidationVPSILNRMQTNQTPP
HHHHHHHHHCCCCCC		5.8417203969
364PhosphorylationSILNRMQTNQTPPTY
HHHHHHHCCCCCCCC		21.68-
367PhosphorylationNRMQTNQTPPTYNKT
HHHHCCCCCCCCCCC		33.0529899451
370PhosphorylationQTNQTPPTYNKTNKF
HCCCCCCCCCCCCCC		40.7129109428
371PhosphorylationTNQTPPTYNKTNKFT
CCCCCCCCCCCCCCC		22.0417203969
373UbiquitinationQTPPTYNKTNKFTHG
CCCCCCCCCCCCCCC		42.9622790023
548PhosphorylationNSFKMKMSVILGIIH
HHHHHHHHHHHHHHH		10.6526643407
561PhosphorylationIHMLFGVSLSLFNHI
HHHHHHHHHHHHHHC		16.7826643407
563PhosphorylationMLFGVSLSLFNHIYF
HHHHHHHHHHHHCCC		24.3326643407
569PhosphorylationLSLFNHIYFKKPLNI
HHHHHHCCCCCCHHH		11.2026643407
674UbiquitinationRHQYLRKKHLGTLNF
HHHHHHHCCCCCEEC		37.3122790023
678PhosphorylationLRKKHLGTLNFGGIR
HHHCCCCCEECCCEE		25.5322324799
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of VPP1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPP1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-257, AND MASSSPECTROMETRY.
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-371, AND MASSSPECTROMETRY.

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