DLL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLL1_MOUSE
• UniProt AC: Q61483
• Protein Name: Delta-like protein 1 {ECO:0000305}
• Gene Name: Dll1
• Organism: Mus musculus (Mouse).
• Sequence Length: 722
• Subcellular Localization: Apical cell membrane ; Single-pass type I membrane protein . Cell junction, adherens junction . Membrane raft . Distributed around adherens junction in the apical endfeet through interactions with MAGI1.; Dll1-derived cell-associated form: Cell membr
• Protein Description: Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner. [PubMed: 21985982]
• Protein Sequence: MGRRSALALAVVSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGSGPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGAGIDPAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLTTQRHLTVGEEWSQDLHSSGRTDLRYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGDRGEKMCDPGWKGQYCTDPICLPGCDDQHGYCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCRNGATCTNTGQGSYTCSCRPGYTGANCELEVDECAPSPCKNGASCTDLEDSFSCTCPPGFYGKVCELSAMTCADGPCFNGGRCSDNPDGGYTCHCPLGFSGFNCEKKMDLCGSSPCSNGAKCVDLGNSYLCRCQAGFSGRYCEDNVDDCASSPCANGGTCRDSVNDFSCTCPPGYTGKNCSAPVSRCEHAPCHNGATCHQRGQRYMCECAQGYGGPNCQFLLPEPPPGPMVVDLSERHMESQGGPFPWVAVCAGVVLVLLLLLGCAAVVVCVRLKLQKHQPPPEPCGGETETMNNLANCQREKDVSVSIIGATQIKNTNKKADFHGDHGAEKSSFKVRYPTVDYNLVRDLKGDEATVRDTHSKRDTKCQSQSSAGEEKIAPTLRGGEIPDRKRPESVYSTSKDTKYQSVYVLSAEKDECVIATEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Methylation	SGPPCACRTFFRVCL CCCCCHHHHHHHHHH	18.95	-
173	Phosphorylation	GRTDLRYSYRFVCDE CCCCCEEEEEEEECC	11.91	24719451
476	N-linked_Glycosylation	PPGYTGKNCSAPVSR CCCCCCCCCCCCCCC	26.73	-
613	Ubiquitination	IIGATQIKNTNKKAD EEEEEEEECCCCCCC	48.15	PubMed
638	Phosphorylation	SFKVRYPTVDYNLVR CEEEECCCCCHHHEE	19.64	24449764
693	Phosphorylation	PDRKRPESVYSTSKD CCCCCCCCCCCCCCC	29.10	24449764
696	Phosphorylation	KRPESVYSTSKDTKY CCCCCCCCCCCCCCC	24.85	24449764

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
693	S	Phosphorylation	Kinase	PKB	P31750	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Mib1	Q80SY4	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Mib2	Q8R516	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Neurl1b	Q0MW30	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
613	K	ubiquitylation	Multi-ubiquitination of LYS-613 by MIB1 promotes both cis and trans-interaction with NOTCH1, as well as activation of Notch signaling.	21985982
638	T	Phosphorylation	Phosphorylation at Ser-696 requires the presence of Ser-693, whereas phosphorylation at Thr-638 and Ser-693 occurs independently of the other sites.	24449764
693	S	Phosphorylation	Phosphorylation at Ser-696 requires the presence of Ser-693, whereas phosphorylation at Thr-638 and Ser-693 occurs independently of the other sites.	24449764
696	S	Phosphorylation	Phosphorylation at Ser-696 requires the presence of Ser-693, whereas phosphorylation at Thr-638 and Ser-693 occurs independently of the other sites.	24449764

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIB1_MOUSE	Mib1	physical	23162128

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.