| UniProt ID | MIB1_MOUSE | |
|---|---|---|
| UniProt AC | Q80SY4 | |
| Protein Name | E3 ubiquitin-protein ligase MIB1 | |
| Gene Name | Mib1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1006 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm. Cell membrane. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock (By simila | |
| Protein Description | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation (By similarity). Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.. | |
| Protein Sequence | MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVAPAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPSLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCASLMKKCVQCRAVVERRVPFITCCGGKSSEDPSDEISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | Ubiquitination | GPDWKWGKQDGGEGH CCCCCCCCCCCCCCC | 44.06 | 27667366 | |
| 63 | Phosphorylation | TAANYRCSGAYDLRI CEEEEECCCCEEEEE | 19.91 | 24899341 | |
| 222 | Ubiquitination | LKCVQDAKGGSFYRD CEEEEECCCCCCCCC | 72.58 | - | |
| 405 | Phosphorylation | SKVAPAGSAISNASG CCCCCCCCHHHCCCH | 25.24 | 23984901 | |
| 408 | Phosphorylation | APAGSAISNASGERL CCCCCHHHCCCHHHH | 26.51 | 21659605 | |
| 411 | Phosphorylation | GSAISNASGERLSQL CCHHHCCCHHHHHHH | 45.50 | 30352176 | |
| 416 | Phosphorylation | NASGERLSQLLKKLF CCCHHHHHHHHHHHH | 25.63 | 30352176 | |
| 421 | Ubiquitination | RLSQLLKKLFETQES HHHHHHHHHHHCCCC | 59.38 | - | |
| 485 | Ubiquitination | DILKLLLKQNVDVEA HHHHHHHHCCCCCCE | 39.53 | 27667366 | |
| 557 | Phosphorylation | LDFGCHPSLQDSEGD HHCCCCCHHCCCCCC | 18.26 | 28285833 | |
| 561 | Phosphorylation | CHPSLQDSEGDTPLH CCCHHCCCCCCCCHH | 30.44 | 28285833 | |
| 691 | Ubiquitination | LLVRAGAKLDIQDKD HHHHCCCCCCCCCCC | 45.86 | 27667366 | |
| 726 | Ubiquitination | QDMQDVGKVDAAWEP HHHHHHCCCCCCCCC | 36.47 | - | |
| 767 | Phosphorylation | AANGADLSIRNKKGQ HHCCCCEEECCCCCC | 21.76 | 28059163 | |
| 772 | Ubiquitination | DLSIRNKKGQSPLDL CEEECCCCCCCCHHC | 66.77 | - | |
| 775 | Phosphorylation | IRNKKGQSPLDLCPD ECCCCCCCCHHCCCC | 35.78 | 21454597 | |
| 784 | Phosphorylation | LDLCPDPSLCKALAK HHCCCCHHHHHHHHH | 54.50 | 21454597 | |
| 787 | Ubiquitination | CPDPSLCKALAKCHK CCCHHHHHHHHHHHH | 52.29 | - | |
| 796 | Ubiquitination | LAKCHKEKVSGQVGS HHHHHHHHCCCCCCC | 46.64 | 27667366 | |
| 798 | Phosphorylation | KCHKEKVSGQVGSRS HHHHHHCCCCCCCCC | 34.28 | 26643407 | |
| 803 | Phosphorylation | KVSGQVGSRSPSMIS HCCCCCCCCCHHHCC | 30.63 | 26643407 | |
| 805 | Phosphorylation | SGQVGSRSPSMISND CCCCCCCCHHHCCCC | 24.03 | 25521595 | |
| 807 | Phosphorylation | QVGSRSPSMISNDSE CCCCCCHHHCCCCCC | 29.96 | 25293948 | |
| 810 | Phosphorylation | SRSPSMISNDSETLE CCCHHHCCCCCCCHH | 26.41 | 25293948 | |
| 813 | Phosphorylation | PSMISNDSETLEECM HHHCCCCCCCHHHHC | 36.41 | 25293948 | |
| 936 | Ubiquitination | GNIPVLQKDKDNTNV CCCCEEEECCCCCCC | 63.69 | 27667366 | |
| 938 | Ubiquitination | IPVLQKDKDNTNVNA CCEEEECCCCCCCCH | 60.97 | 27667366 | |
| 949 | Ubiquitination | NVNADVQKLQQQLQD CCCHHHHHHHHHHHH | 48.38 | - | |
| 990 | Phosphorylation | QLCGDRMSECPICRK HHCCCHHHCCHHHHH | 36.62 | - |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIB1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIB1_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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