JAG2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JAG2_MOUSE
• UniProt AC: Q9QYE5
• Protein Name: Protein jagged-2
• Gene Name: Jag2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1247
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems..
• Protein Sequence: MRARGWGRLPRRLLLLLVLCVQATRPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGRDECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPPAGAAGDRARARSRTGGHQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPDEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGKFCDECVPYPGCVHGSCVEPWHCDCETNWGGLLCDKDLNYCGSHHPCVNGGTCINAEPDQYLCACPDGYLGKNCERAEHACASNPCANGGSCHEVPSGFECHCPSGWNGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCLPGWKGINCQININDCHGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELEYDKCASSPCRRGGICEDLVDGFRCHCPRGLSGLHCEVDMDLCEPSPCLNGARCYNLEGDYYCACPEDFGGKNCSVPRDTCPGGACRVIDGCGFEAGSRARGVAPSGICGPHGHCVSLPGGNFSCICDSGFTGTYCHENIDDCMGQPCRNGGTCIDEVDSFRCFCPSGWEGELCDINPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCTIAKNSSCVPNPCVNGGTCVGSGDSFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRSGPRCQEVVIFTRPCWSRGMSFPHGSSWMEDCNSCRCLDGHRDCSKVWCGWKPCLLSGQPSDPSAQCPPGQQCQEKAVGQCLQPPCENWGECTAEEPLPPSTPCQPRSSHLDNNCARLTLRFNRDQVPQGTTVGAICSGIRALPATRAAAHDRLLLLLCDRASSGASAVEVAVSFSPARDLPDSSLIQSTAHAIVAAITQRGNSSLLLAVTEVKVETVVMGGSSTGLLVPVLCSVFSVLWLACVVICVWWTRKRRKERERSRLPRDESANNQWAPLNPIRNPIERPGGSGLGTGGHKDILYQCKNFTPPPRRAGEALPGPAGHGAGGEDEEDEELSRGDGDSPEAEKFISHKFTKDPSCSLGRPARWAPGPKVDNRAVRSTKDVRRAGRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
153	N-linked_Glycosylation	VEAWDWDNDTTPDEE EEECCCCCCCCCCHH	44.25	-
570	N-linked_Glycosylation	PEDFGGKNCSVPRDT CHHHCCCCCCCCCCC	26.94	-
619	N-linked_Glycosylation	CVSLPGGNFSCICDS EEECCCCCEEEEECC	31.41	-
752	N-linked_Glycosylation	STCTIAKNSSCVPNP CCEEEECCCCCCCCC	30.08	-
1060	N-linked_Glycosylation	AAITQRGNSSLLLAV HHHHHHCCCEEEEEE	30.52	-
1125	Phosphorylation	SRLPRDESANNQWAP HCCCCCHHHCCCCCC	40.50	28066266
1164	Phosphorylation	LYQCKNFTPPPRRAG HHHCCCCCCCCCCCC	44.25	24719451
1193	Phosphorylation	DEEDEELSRGDGDSP CHHHHHHHCCCCCCH	37.18	29899451
1199	Phosphorylation	LSRGDGDSPEAEKFI HHCCCCCCHHHHHHH	30.12	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JAG2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JAG2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JAG2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of JAG2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.