JAG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JAG1_MOUSE
• UniProt AC: Q9QXX0
• Protein Name: Protein jagged-1
• Gene Name: Jag1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1218
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis..
• Protein Sequence: MRSPRTRGRPGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGVRNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTIQPDSIIEKASHSGMINPSRQWQTLKQNTGIAHFEYQIRVTCDDHYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPDCNKAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGTCNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSSGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNARSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTTCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCKNGGTCIDGVNSYKCICSDGWEGAHCENNINDCSQNPCHYGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEVDTFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGDSFTCVCKEGWEGPICTQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYQCICPPGHSGAKCHEVSGRSCITMGRVILDGAKWDDDCNTCQCLNGRVACSKVWCGPRPCRLHKSHNECPSGQSCIPVLDDQCFVRPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSLSANNEIHVAISAEDIRDDGNPVKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVAWVCCLVTAFYWCVRKRRKPSSHTHSAPEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTHNSEVEEDDMDKHQQKVRFAKQPVYTLVDREEKAPSGTPTKHPNWTNKQDNRDLESAQSLNRMEYIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
143	N-linked_Glycosylation	VEAWDSSNDTIQPDS EEEECCCCCCCCCCH	55.16	-
217	N-linked_Glycosylation	YACDQNGNKTCMEGW EEECCCCCCCCCCCC	43.97	-
382	N-linked_Glycosylation	IDDCSPNNCSHGGTC CHHCCCCCCCCCCCH	31.86	-
559	N-linked_Glycosylation	PEDYEGKNCSHLKDH CCCCCCCCCHHHCHH	43.30	-
745	N-linked_Glycosylation	TTCNIARNSSCLPNP CCEEECCCCCCCCCC	29.29	-
960	N-linked_Glycosylation	YYQDNCANITFTFNK HHCCCCEEEEEEECH	35.71	-
991	N-linked_Glycosylation	RNLNILKNVSAEYSI HCCCHHCCCCEEEEE	29.54	-
1045	N-linked_Glycosylation	LVSKRDGNSSLIAAV HHHCCCCCCHHHEEE	32.49	-
1064	N-linked_Glycosylation	VQRRPLKNRTDFLVP CCCCCCCCCCCCHHH	60.82	-
1139	Phosphorylation	NTVPIKDYENKNSKM CCCCCCCCCCCCCCC	19.19	29514104
1144	Phosphorylation	KDYENKNSKMSKIRT CCCCCCCCCCHHHHC	31.20	29514104
1151	Phosphorylation	SKMSKIRTHNSEVEE CCCHHHHCCCCCCCC	28.96	26643407
1154	Phosphorylation	SKIRTHNSEVEEDDM HHHHCCCCCCCCCHH	35.10	26643407
1176	Phosphorylation	RFAKQPVYTLVDREE HHCCCCEEEEEECHH	10.88	29514104
1210	Phosphorylation	RDLESAQSLNRMEYI CCHHHHHHHHCHHHC	27.59	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Neurl1	Q923S6	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JAG1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JAG1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of JAG1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.