DLL4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLL4_MOUSE
• UniProt AC: Q9JI71
• Protein Name: Delta-like protein 4
• Gene Name: Dll4
• Organism: Mus musculus (Mouse).
• Sequence Length: 686
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Involved in the Notch signaling pathway as Notch ligand. [PubMed: 11134954 Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (By similarity Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types]
• Protein Sequence: MTPASRSACRWALLLLAVLWPQQRAAGSGIFQLRLQEFVNQRGMLANGQSCEPGCRTFFRICLKHFQATFSEGPCTFGNVSTPVLGTNSFVVRDKNSGSGRNPLQLPFNFTWPGTFSLNIQAWHTPGDDLRPETSPGNSLISQIIIQGSLAVGKIWRTDEQNDTLTRLSYSYRVICSDNYYGESCSRLCKKRDDHFGHYECQPDGSLSCLPGWTGKYCDQPICLSGCHEQNGYCSKPDECICRPGWQGRLCNECIPHNGCRHGTCSIPWQCACDEGWGGLFCDQDLNYCTHHSPCKNGSTCSNSGPKGYTCTCLPGYTGEHCELGLSKCASNPCRNGGSCKDQENSYHCLCPPGYYGQHCEHSTLTCADSPCFNGGSCRERNQGSSYACECPPNFTGSNCEKKVDRCTSNPCANGGQCQNRGPSRTCRCRPGFTGTHCELHISDCARSPCAHGGTCHDLENGPVCTCPAGFSGRRCEVRITHDACASGPCFNGATCYTGLSPNNFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLVVLLVLLVMVVVAVRQLRLRRPDDESREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKLQNHTLDYNLAPGLLGRGGMPGKYPHSDKSLGEKVPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIATEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	N-linked_Glycosylation	EGPCTFGNVSTPVLG CCCCCCCCCCCCCCC	22.00	-
109	N-linked_Glycosylation	NPLQLPFNFTWPGTF CCEECCEEEECCCEE	31.34	-
162	N-linked_Glycosylation	IWRTDEQNDTLTRLS EEECCCCCCCEEEEE	42.03	-
297	N-linked_Glycosylation	THHSPCKNGSTCSNS CCCCCCCCCCCCCCC	57.26	-
394	N-linked_Glycosylation	YACECPPNFTGSNCE CEEECCCCCCCCCCC	32.05	-
577	Ubiquitination	NNLSDFQKDNLIPAA HCCHHHHHCCCCCHH	48.88	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Mib1	Q80SY4	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Mib2	Q8R516	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Neurl1b	Q0MW30	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DLL4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLL4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIB1_MOUSE	Mib1	physical	23162128

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.