NUP88_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUP88_MOUSE
• UniProt AC: Q8CEC0
• Protein Name: Nuclear pore complex protein Nup88
• Gene Name: Nup88
• Organism: Mus musculus (Mouse).
• Sequence Length: 753
• Subcellular Localization: Nucleus, nuclear pore complex.
• Protein Description: Essential component of nuclear pore complex..
• Protein Sequence: MAAAVGPLGDGELWQSWLPNHVVFLRLREGVRNQSPAEAEKPAASTSPSCPSLPPHLPTRNLVFGLGGELFLWDAEGSAFLVVRLRGPSGGGVEPPLSQYQRLLCINPPLFEIHQVLLSPTQHHVALIGSKGLMALELPQRWGKDSEFEGGKATVNCSTIPIAERFFTSSTSLTLKHAAWYPSEMLDPHIVLLTSDNVIRIYSLREPQTPTKVIVLSEAEEESLILNKGRAYTASLGETAVAFDFGPLVTVSKNIFEQKDRDVVAYPLYILYENGETFLTYVSLLHSPGNIGKLLGPLPMHPAAEDNYGYDACAILCLPCVPNILVIATESGMLYHCVVLEGEEEDDQTLEKSWDPRADFIPSLYVFECVELELALKLASGEDDPFASDFSCPIKLHRDPKCPSRYHCSHEAGVHSVGLTWIHKLHKFLGSDEEDKDSLQELTAEQKCFVEHILCTKPLPCRQPAPIRGFWIVPDILGPTMICITSTYECLIRPLLSTVHPASPPLLCTQEDAEVAESPLRILAETPDSFEKHIKRILQRSAANPAFLKNCSARSSEKDLAPPPEECLQLISRATQVFREQYILKQDLAKEEIQRRVKLLCDQKRKQLEDLNYCREERVSHLFRKSLREMAERLADKYEEAKEKQEDIMNRMKKVLHSFHAQLPVLSDSERDMKKELQLIPDQLRHLGNAIKQVTMKKDYQQRKMEKVLSPQKPTITLSAYQRKCIQSILKEEGEHIREMVKQINDIRNHVTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAVGPLG ------CCCCCCCCC	12.25	-
35	Phosphorylation	REGVRNQSPAEAEKP CCCCCCCCHHHHCCC	29.62	23684622
45	Phosphorylation	EAEKPAASTSPSCPS HHCCCCCCCCCCCCC	31.37	22942356
46	Phosphorylation	AEKPAASTSPSCPSL HCCCCCCCCCCCCCC	39.67	25619855
47	Phosphorylation	EKPAASTSPSCPSLP CCCCCCCCCCCCCCC	16.60	26824392
49	Phosphorylation	PAASTSPSCPSLPPH CCCCCCCCCCCCCCC	38.13	22942356
52	Phosphorylation	STSPSCPSLPPHLPT CCCCCCCCCCCCCCC	58.81	22942356
59	Phosphorylation	SLPPHLPTRNLVFGL CCCCCCCCCCEEEEE	38.25	25619855
159	Phosphorylation	KATVNCSTIPIAERF EEEEECCCCCCHHHH	32.73	26643407
168	Phosphorylation	PIAERFFTSSTSLTL CCHHHHCCCCCCEEE	21.03	26643407
169	Phosphorylation	IAERFFTSSTSLTLK CHHHHCCCCCCEEEE	26.85	26643407
170	Phosphorylation	AERFFTSSTSLTLKH HHHHCCCCCCEEEEE	20.96	26745281
171	Phosphorylation	ERFFTSSTSLTLKHA HHHCCCCCCEEEEEE	27.76	26643407
172	Phosphorylation	RFFTSSTSLTLKHAA HHCCCCCCEEEEEEC	22.70	26745281
174	Phosphorylation	FTSSTSLTLKHAAWY CCCCCCEEEEEECCC	33.26	26643407
209	Phosphorylation	YSLREPQTPTKVIVL EECCCCCCCCEEEEE	43.57	25338131
228	Ubiquitination	EESLILNKGRAYTAS HHHEEECCCCEEEEE	46.45	-
259	Malonylation	SKNIFEQKDRDVVAY ECCHHHCCCCCEEEE	47.75	26320211
380	Phosphorylation	ELALKLASGEDDPFA HHHHHHHCCCCCCCC	53.83	28066266
431	Phosphorylation	KLHKFLGSDEEDKDS HHHHHHCCCHHCHHH	43.95	26745281
438	Phosphorylation	SDEEDKDSLQELTAE CCHHCHHHHHHHHHH	37.38	28066266
497	Phosphorylation	CLIRPLLSTVHPASP HHHHHHHHCCCCCCC	35.75	23649490
498	Phosphorylation	LIRPLLSTVHPASPP HHHHHHHCCCCCCCC	23.85	25777480
503	Phosphorylation	LSTVHPASPPLLCTQ HHCCCCCCCCEEECH	31.34	26824392
509	Phosphorylation	ASPPLLCTQEDAEVA CCCCEEECHHCHHHH	34.66	25777480
518	Phosphorylation	EDAEVAESPLRILAE HCHHHHCCCHHHHHC	21.35	28066266
526	Phosphorylation	PLRILAETPDSFEKH CHHHHHCCCCHHHHH	27.13	26824392
529	Phosphorylation	ILAETPDSFEKHIKR HHHCCCCHHHHHHHH	36.19	25159016
541	Phosphorylation	IKRILQRSAANPAFL HHHHHHHHCCCHHHH	20.83	28066266
551	Glutathionylation	NPAFLKNCSARSSEK CHHHHHHCCCCCCCC	3.00	24333276
598	Acetylation	EEIQRRVKLLCDQKR HHHHHHHHHHHHHHH	33.65	23806337
598	Malonylation	EEIQRRVKLLCDQKR HHHHHHHHHHHHHHH	33.65	26320211
710	Phosphorylation	RKMEKVLSPQKPTIT HHHHHHCCCCCCEEE	28.42	26824392
715	Phosphorylation	VLSPQKPTITLSAYQ HCCCCCCEEEEEHHH	33.36	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUP88_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUP88_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUP88_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XPO1_HUMAN	XPO1	physical	20360068
NUP62_HUMAN	NUP62	physical	20360068
RAN_HUMAN	RAN	physical	20360068
NU214_HUMAN	NUP214	physical	20360068
NUP88_HUMAN	NUP88	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.