PRUN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRUN1_MOUSE
• UniProt AC: Q8BIW1
• Protein Name: Exopolyphosphatase PRUNE1
• Gene Name: Prune1
• Organism: Mus musculus (Mouse).
• Sequence Length: 454
• Subcellular Localization: Cytoplasm. Nucleus. Cell junction, focal adhesion.
• Protein Description: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization..
• Protein Sequence: MEDYLQDCRAALQDSRPLHVVLGNEACDLDSMVSALALAFYLTKTSEAEDIFIPVLNIKRSELPLRGDNVFFLQEVKIPEPALIFRDEIDLLALHQAGQLTLILVDHHILPKSDAALEEAVAEVLDHRPIEQKYCPPCHVSVELVGSCATLVTERILQGAPETLDRQTAALLHGTIILDCVNMDTNIGKATPKDSKYVEELEALFPDLPKRKDIFDSLQKAKFDVSGLTTEQMLRKDQKTVYRQGTKVAISAIYMDLKAFLQRTDLFTDLSSFCHDHSYDALVAMTIFFNTQNEPVRQLAIFCPHEALRMTICGILERSTSPPLKLTPIPSTSPNLQAYHQGNTQVSRKKLLPVLQEALSAYLDSAKMASGQSEVAVGMSREQVDKDLDKASNSLISGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKFSAEAVFEKCSQISLSQSARACTSNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDYLQDC -------CHHHHHHH		-
264	Phosphorylation	LKAFLQRTDLFTDLS HHHHHHCCCCHHHHH		-
380	Phosphorylation	SEVAVGMSREQVDKD CHHHHCCCHHHHHHH		28973931
392	Phosphorylation	DKDLDKASNSLISGL HHHHHHHHHHHHHCC		26643407
394	Phosphorylation	DLDKASNSLISGLSQ HHHHHHHHHHHCCCC		26643407
397	Phosphorylation	KASNSLISGLSQDEE HHHHHHHHCCCCCCC		26643407
400	Phosphorylation	NSLISGLSQDEEDPP HHHHHCCCCCCCCCC		21082442
411	Phosphorylation	EDPPLPPTPMNSLVD CCCCCCCCCCHHHCC		26643407
415	Phosphorylation	LPPTPMNSLVDECPL CCCCCCHHHCCCCCC		26643407
442	Phosphorylation	FEKCSQISLSQSARA HHHHHHCCHHHHHHH		29899451
446	Phosphorylation	SQISLSQSARACTSN HHCCHHHHHHHHHCC		29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRUN1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRUN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRUN1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PRUN1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.