AGK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGK_MOUSE
• UniProt AC: Q9ESW4
• Protein Name: Acylglycerol kinase, mitochondrial {ECO:0000250|UniProtKB:Q53H12}
• Gene Name: Agk {ECO:0000312|MGI:MGI:1917173}
• Organism: Mus musculus (Mouse).
• Sequence Length: 421
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein . Mitochondrion intermembrane space . Localizes in the mitochondrion intermembrane space, where it associates with the inner membrane. It is unclear whether the N-terminal hydrophobic region
• Protein Description: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. [PubMed: 15252046 Does not phosphorylate sphingosine]
• Protein Sequence: MTAFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTVVKTDYEGQAKKLLELMESTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGQTSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVYAMTGLRWGSFRDAGVKVSKYWYLGPLKTKAAHFFSTLQEWPQTHQASISYTGPRERPPIEPEETPPRPSLYRRILRRLASFWAQPQDASSREVSPEVWKDVQLSTIELSITTRNTQLDLMSKEDFMNICIEPDTVSKGDFIIIGSKKVRDPGLRAAGTECLQASHCTLVLPEGTEGSFSIDSEEYEAMPVEVKLLPRKLRFFCDPRKREQMLPSTSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MTAFFKTLRNHWK --CCHHHHHHHHHHC	39.95	-
34	S-nitrosocysteine	HWLYGKHCDNLLRRA CHHHHHHHHHHHHHH	4.17	-
34	S-nitrosylation	HWLYGKHCDNLLRRA CHHHHHHHHHHHHHH	4.17	21278135
268	Phosphorylation	PPIEPEETPPRPSLY CCCCCCCCCCCHHHH	36.61	25338131
284	Phosphorylation	RILRRLASFWAQPQD HHHHHHHHHHCCCCC	26.39	22817900
308	Phosphorylation	VWKDVQLSTIELSIT HHHCCEEEEEEEEEE	15.39	25777480
309	Phosphorylation	WKDVQLSTIELSITT HHCCEEEEEEEEEEC	27.36	51458699
313	Phosphorylation	QLSTIELSITTRNTQ EEEEEEEEEECCCCH	12.71	25777480
315	Phosphorylation	STIELSITTRNTQLD EEEEEEEECCCCHHC	19.14	36250009
316	Phosphorylation	TIELSITTRNTQLDL EEEEEEECCCCHHCC	21.91	25777480
319	Phosphorylation	LSITTRNTQLDLMSK EEEECCCCHHCCCCH	27.50	25777480
325	Phosphorylation	NTQLDLMSKEDFMNI CCHHCCCCHHHHHHE	39.94	25777480
407	S-nitrosocysteine	PRKLRFFCDPRKREQ CCCHHHCCCHHHHHH	6.91	-
407	S-nitrosylation	PRKLRFFCDPRKREQ CCCHHHCCCHHHHHH	6.91	21278135
420	Phosphorylation	EQMLPSTSQ------ HHCCCCCCC------	37.93	22982522

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGK_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AGK_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.