LTN1_MOUSE - dbPTM
LTN1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LTN1_MOUSE
UniProt AC Q6A009
Protein Name E3 ubiquitin-protein ligase listerin
Gene Name Ltn1
Organism Mus musculus (Mouse).
Sequence Length 1767
Subcellular Localization
Protein Description E3 ubiquitin-protein ligase. [PubMed: 19196968 Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity Ubiquitination leads to Vcp/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity]
Protein Sequence MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSHSDLGYVPAVQGAEDIDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGIMCTERDTEAVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKHLAPYLKSVMGYWLMAQCDTYPPAALAAKDAFEAAFPPSKQPEAIAFCKEEITTVLQDHLLKETPDTLSDPQTVPEEEREAKFHRVVTCSLLALKRLLCFLPNNELDSLEEKFKSLLSQNKFWKYGKHSVPQVRSAYFELVSALCQHVPQVMKEEAAKVSPSVLLSIDDSDPVVCPALWEAVLYTLTTIEDCWFHVNAKKSVFPKLMAMIREGGRGLAAVMYPYLLPFISKLPQSITEPKLDFFKNFLTSLVTGLSTERTKSSSSECSAVISAFFECLRFIMQQNLGEEEMVQMLINEQLIPFIDTVLKDSGLHHGPMFDHLADTLSSWEAKADAERDPGAVYNLENVLLSFWGRLSEICTEKIRQPEADVKSVLCVSSLVGVLQRPRSSLKLHRKKTAQVRFAINIPEAHKGDEKSMSSEGENSEGSDGGAQSPLSNTSSDLVSPLRKKPLEDLVCKLAEVSISFVNERKSEQHLQFLSTLLDSFSSVQVFNILLSDKQKNVVKAKPLEITKLAEKNPAVKFLYHKLIGWLNDSQKEDGGFLVDILYSALRCCDSGVERKEVLDDLTKEDLKWSSLLQVIEKACSSSDKHALVTPWLKGSILGEKLVALADCLCDKDLEATTSESHSSEQWSLLRLALSQHVKNDYLIGEVYVGRIIVKLHETLSKTKDLSEAANSDSSVSFVCDVVHSFFSSAGGGLLMPPSEDLLLTLFQLCAQSKERTHLPDFLICKLKNTLLSGVNLLVHQTASTYEQSTFLRLSVLWLKDQVQSSALDNTSLQVLLSAAGDLLGTLVESEDTSLLGVYIGSVMPSDSEWEKMRQALPVQWLHRPLLEGRLSLNYECFKTDFKEQDTKTLPNHLCTSSLLSKMILVAQKKKLVLEDNVLEKIIAELLYSLQWCEELDNAPSFLSGFCGILQKMNITYSNLSVLSETSSLLQLLFDRSRKNGTLWSLIIAKLILSRSISSDEVKPYYKRKESFFPLTEGSLHTIQSLCPFLSKEEKKEFSAQCIPAFLGWTKEDLCSINGAFGHLAIFNSCLQTRSIDDKQLLHGILKIITSWRKQHEDIFLFSCNLSEASPEVLGLNIEIMRFLSLFLKHCAYPLPLADSEWDFIMCSMLAWLETTSENQALYSVPLVQLFACVSFDLACDLCAFFDSITPDIVDNLPVNLISEWKEFFSKGIHSLLLPLLVNAIGENKDLSETSFQNAMLKPMCETLTYISKDQLLSHKLPARLVASQKTNLPEHLQTLLNTLTPLLLFRARPVQIAAYHMLCKLMPELPQHDQDNLRSYGDEEEEPALSPPAALMSLLSSQEELLENVLGCVPVGQIVTVKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYSMYLRKTKSLNKLLYHLFRLMPENPTYGETAIEVSSKDPKTFFTEEVQLSIRETATLPYHIPHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSNVLSFQEISSVQTSTQLFNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSITVESGKRIGVAVQQWRNWMLQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETFF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationTKGNLRPSNSGRAAE
CCCCCCCCCHHHHHH		36.8729472430
18PhosphorylationGNLRPSNSGRAAELL
CCCCCCCHHHHHHHH		33.7129472430
226PhosphorylationAKFHRVVTCSLLALK
HHHHHHHHHHHHHHH		8.1024719451
228PhosphorylationFHRVVTCSLLALKRL
HHHHHHHHHHHHHHH		19.6324719451
536PhosphorylationLKLHRKKTAQVRFAI
CHHCCCCCCEEEEEE		25.9223375375
555PhosphorylationAHKGDEKSMSSEGEN
HHCCCCCCCCCCCCC		23.1126643407
557PhosphorylationKGDEKSMSSEGENSE
CCCCCCCCCCCCCCC		32.1226643407
558PhosphorylationGDEKSMSSEGENSEG
CCCCCCCCCCCCCCC		40.7626643407
563PhosphorylationMSSEGENSEGSDGGA
CCCCCCCCCCCCCCC		38.7526643407
566PhosphorylationEGENSEGSDGGAQSP
CCCCCCCCCCCCCCC		29.0922817900
572PhosphorylationGSDGGAQSPLSNTSS
CCCCCCCCCCCCCCC		27.5521183079
673PhosphorylationLIGWLNDSQKEDGGF
HHHHHCCCCCCCCCC		41.9224719451
707UbiquitinationEVLDDLTKEDLKWSS
HHHHHCCHHHHCHHH		57.4322790023
785PhosphorylationSQHVKNDYLIGEVYV
HHHHCCCEEECEEEH		15.0417203969
1353PhosphorylationPMCETLTYISKDQLL
HHHHHHHHCCHHHHH		13.3029514104
1363UbiquitinationKDQLLSHKLPARLVA
HHHHHHCCCCHHHHH		53.4422790023
1537UbiquitinationTAIEVSSKDPKTFFT
CEEEECCCCCCCCCC		71.2322790023
1550PhosphorylationFTEEVQLSIRETATL
CCCEEEHHHHHHCCC		11.5122942356
1614PhosphorylationLSFQEISSVQTSTQL
CCHHHHCCCCCCCCH		24.73-
1633PhosphorylationTVKARATTREVMATY
EEECCCCCCHHHHCE		24.69-
1748PhosphorylationKFHSACLYKWFTSSN
HCHHHHHHHHHHCCC		13.1725619855
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LTN1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LTN1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LTN1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LTN1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LTN1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-785, AND MASSSPECTROMETRY.

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