TWF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TWF2_MOUSE
• UniProt AC: Q9Z0P5
• Protein Name: Twinfilin-2
• Gene Name: Twf2
• Organism: Mus musculus (Mouse).
• Sequence Length: 349
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell projection, stereocilium . Perinuclear and G-actin-rich cortical actin structure sublocalization. Isoform 2 found also along myofibrils in cardiomyocytes (PubMed:18837697). Localized in c
• Protein Description: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia..
• Protein Sequence: MAHQTGIHATEELKEFFAKARAGSIRLIKVIIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSLAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTEPTNVAQLPSRIPRDAARYHFFLYKHTHEGDALESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFQLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGEDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAHQTGIHA ------CCCCCCCCC	11.96	-
14	Acetylation	IHATEELKEFFAKAR CCCCHHHHHHHHHHH	56.61	22826441
24	Phosphorylation	FAKARAGSIRLIKVI HHHHHCCCEEEEEEE	11.98	81017669
67	Glutathionylation	LLDAQEPCYLLFRLD HCCCCCCEEEEEEEC	3.53	24333276
98	Acetylation	DNSPVRLKMLYAATR CCCHHHHHHHHHHHH	19.12	22826441
141	Glutathionylation	YQKHLSSCAAPAPLT HHHHHHCCCCCCCCC	3.17	24333276
167	Phosphorylation	NEVKTEISVESKHQT CCCCCEEEECCCCCC	17.38	101544679
170	Phosphorylation	KTEISVESKHQTLQG CCEEEECCCCCCHHH	33.03	29176673
211	Phosphorylation	KLDLERETIELVHTE EEHHHHCEEEEEECC	26.44	26239621
217	Phosphorylation	ETIELVHTEPTNVAQ CEEEEEECCCCCHHH	35.86	26239621
220	Phosphorylation	ELVHTEPTNVAQLPS EEEECCCCCHHHCCC	35.77	26239621
277	Phosphorylation	MLYSSCKSRLLDSVE HHHHHHHHHHHHHHC	32.27	24068923
282	Phosphorylation	CKSRLLDSVEQDFQL HHHHHHHHHCHHHHH	27.76	24068923
309	Phosphorylation	ELTAEFLYDEVHPKQ EEEEHHHHCCCCHHH	18.51	22817900
349	Phosphorylation	PGENGEDS------- CCCCCCCC-------	37.51	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TWF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TWF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TWF2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TWF2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-309, AND MASSSPECTROMETRY.
PubMed: 18034455