M2OM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M2OM_MOUSE
• UniProt AC: Q9CR62
• Protein Name: Mitochondrial 2-oxoglutarate/malate carrier protein
• Gene Name: Slc25a11
• Organism: Mus musculus (Mouse).
• Sequence Length: 314
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis. [PubMed: 21448454]
• Protein Sequence: MAATASPGAGRMDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKTEGLKGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKALIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALVRIAREEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIVKTRIQNMRMIDGKPEYKNGLDVLLKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAATASPGA ------CCCCCCCCC	17.33	-
4	Phosphorylation	----MAATASPGAGR ----CCCCCCCCCCC	20.38	20531401
6	Phosphorylation	--MAATASPGAGRMD --CCCCCCCCCCCCC	21.36	29895711
57	Succinylation	QLSGEGAKTREYKTS HHCCCCCCCHHHHHH	60.00	23806337
57	Succinylation	QLSGEGAKTREYKTS HHCCCCCCCHHHHHH	60.00	-
61	Phosphorylation	EGAKTREYKTSFHAL CCCCCHHHHHHHHHH	19.10	24925903
69	Phosphorylation	KTSFHALTSILKTEG HHHHHHHHHHHHHCC	17.95	24925903
70	Phosphorylation	TSFHALTSILKTEGL HHHHHHHHHHHHCCC	27.12	24925903
73	Acetylation	HALTSILKTEGLKGI HHHHHHHHHCCCCHH	42.75	-
93	Phosphorylation	AGLLRQATYTTTRLG HHHHHHCCCCCHHHC	17.05	22871156
94	Phosphorylation	GLLRQATYTTTRLGI HHHHHCCCCCHHHCH	12.71	22871156
95	Phosphorylation	LLRQATYTTTRLGIY HHHHCCCCCHHHCHH	19.82	28576409
102	Phosphorylation	TTTRLGIYTVLFERL CCHHHCHHHHHHHHH	6.76	22817900
103	Phosphorylation	TTRLGIYTVLFERLT CHHHCHHHHHHHHHH	14.60	20415495
110	Phosphorylation	TVLFERLTGADGTPP HHHHHHHHCCCCCCC	36.22	21454597
162	Ubiquitination	ADQRRGYKNVFNALV HHHHHCHHHHHHHHH	49.84	-
162	Acetylation	ADQRRGYKNVFNALV HHHHHCHHHHHHHHH	49.84	24062335
184	S-nitrosocysteine	VPTLWRGCIPTMARA CCCHHHCHHHHHHHH	2.24	-
184	S-nitrosylation	VPTLWRGCIPTMARA CCCHHHCHHHHHHHH	2.24	21278135
201	Phosphorylation	VNAAQLASYSQSKQF HCHHHHHHHHCCCCH	33.63	20415495
202	Phosphorylation	NAAQLASYSQSKQFL CHHHHHHHHCCCCHH	12.72	22817900
203	Phosphorylation	AAQLASYSQSKQFLL HHHHHHHHCCCCHHH	26.03	29899451
205	Phosphorylation	QLASYSQSKQFLLDS HHHHHHCCCCHHHHC	23.60	22871156
256	Acetylation	NMRMIDGKPEYKNGL HCEECCCCCCCCCHH	30.81	23576753
268	Acetylation	NGLDVLLKVVRYEGF CHHHHHHHHHHHCCH	34.23	23201123

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of M2OM_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M2OM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M2OM_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of M2OM_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-102 AND TYR-202, ANDMASS SPECTROMETRY.
PubMed: 18034455