RAB1B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB1B_MOUSE
• UniProt AC: Q9D1G1
• Protein Name: Ras-related protein Rab-1B
• Gene Name: Rab1b
• Organism: Mus musculus (Mouse).
• Sequence Length: 201
• Subcellular Localization: Cytoplasm . Membrane ; Lipid-anchor ; Cytoplasmic side . Preautophagosomal structure membrane ; Lipid-anchor ; Cytoplasmic side . Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum..
• Protein Sequence: MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGVPFLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGGERPNLKIDSTPVKPASGGCC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNPEYDYL -------CCHHHHHH	19.94	-
5	Phosphorylation	---MNPEYDYLFKLL ---CCHHHHHHHHHH	15.90	22499769
7	Phosphorylation	-MNPEYDYLFKLLLI -CCHHHHHHHHHHHH	17.09	22499769
17	Phosphorylation	KLLLIGDSGVGKSCL HHHHHCCCCCCCCCE	30.11	22817900
36	Phosphorylation	ADDTYTESYISTIGV CCCCCCHHHHHHEEC	21.70	25159016
37	Phosphorylation	DDTYTESYISTIGVD CCCCCHHHHHHEECC	7.83	25159016
39	Phosphorylation	TYTESYISTIGVDFK CCCHHHHHHEECCEE	13.02	25159016
55	Ubiquitination	RTIELDGKTIKLQIW EEEEECCEEEEEEEE	46.90	-
58	Ubiquitination	ELDGKTIKLQIWDTA EECCEEEEEEEECCC	39.30	-
72	Phosphorylation	AGQERFRTITSSYYR CCHHHHHHHHHHHHC	26.37	26239621
74	Phosphorylation	QERFRTITSSYYRGA HHHHHHHHHHHHCCC	15.82	26745281
75	Phosphorylation	ERFRTITSSYYRGAH HHHHHHHHHHHCCCC	16.70	24453211
76	Other	RFRTITSSYYRGAHG HHHHHHHHHHCCCCE	19.96	-
76	Phosphorylation	RFRTITSSYYRGAHG HHHHHHHHHHCCCCE	19.96	26745281
76	O-(2-cholinephosphoryl)serine	RFRTITSSYYRGAHG HHHHHHHHHHCCCCE	19.96	-
77	Phosphorylation	FRTITSSYYRGAHGI HHHHHHHHHCCCCEE	9.28	29472430
109	Phosphorylation	WLQEIDRYASENVNK HHHHHHHHHCCCHHH	15.67	22499769
111	Phosphorylation	QEIDRYASENVNKLL HHHHHHHCCCHHHHH	22.29	22499769
116	Ubiquitination	YASENVNKLLVGNKS HHCCCHHHHHCCCHH	38.63	-
137	Acetylation	VVDNTTAKEFADSLG ECCCCCHHHHHHHHC	51.80	23954790
164	Phosphorylation	NVEQAFMTMAAEIKK CHHHHHHHHHHHHHH	9.37	29514104
179	Phosphorylation	RMGPGAASGGERPNL HHCCCCCCCCCCCCC	46.96	24899341
200	Geranylgeranylation	VKPASGGCC------ CCCCCCCCC------	2.58	-
201	Methylation	KPASGGCC------- CCCCCCCC-------	7.65	-
201	Geranylgeranylation	KPASGGCC------- CCCCCCCC-------	7.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB1B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB1B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB1B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RAB1B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.