NSD2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSD2_MOUSE
• UniProt AC: Q8BVE8
• Protein Name: Histone-lysine N-methyltransferase NSD2
• Gene Name: Nsd2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1365
• Subcellular Localization: Nucleus . Chromosome.
• Protein Description: Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity..
• Protein Sequence: MEFSIRKSPLSVQKVVKCMKMKQTPEILGSANGKTQNCEVNHECSVFLSKAQLSNSLQEGVMQKFNGHDALPFLPAEKLKDLTSCVFNGEPGAHDTKLCFEAQEVKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDGAADVSQSEENEQKSDNKTRRNRKRSIKYDSLLEQGLVEAALVSKISSPADKKIPVKKESCPNTGRDRDLLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRAQWEMGIVQAEEAASMSIEERKAKFTFLYVGDQLHLNPQVAKEAGIVTEPLGEMVDSSGASEEAAVDPGSVREEDIPTKRRRRTKRSSSAENQEGDPGTDKSTPPKMAEAEPKRGVGSPAGRKKSTGSAPRSRKGDSAAQFLVFCQKHRDEVVAEHPDASGEEIEELLGSQWSMLNEKQKARYNTKFSLMISAQSEEDSGNGNGKKRSHTKRADDPAEDVDVEDAPRKRLRADKHSLRKRETITDKTARTSSYKAIEAASSLKSQAATKNLSDACKPLKKRNRASATASSALGFNKSSSPSASLTEHEVSDSPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEYVCQLCEKTGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCTECASGIHSCFVCKESKMEVKRCVVNQCGKFYHEACVKKYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTARKGKRHHTHVNVSWCFVCSKGGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQSYCCEHDLRADSSSSTKTEKPFPESLKSKGKRKKRRCWRRVTDGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEFSIRKSPLS ----CCCCCCCCCCC	25.44	24759943
8	Phosphorylation	MEFSIRKSPLSVQKV CCCCCCCCCCCHHHH	22.64	26824392
11	Phosphorylation	SIRKSPLSVQKVVKC CCCCCCCCHHHHHHH	26.36	24759943
54	Phosphorylation	FLSKAQLSNSLQEGV EEEHHHHCCHHHHHH	16.58	28066266
56	Phosphorylation	SKAQLSNSLQEGVMQ EHHHHCCHHHHHHHH	28.22	28066266
110	Phosphorylation	QEVKGIGTPPNTTPI EEECCCCCCCCCCCC	33.38	27087446
114	Phosphorylation	GIGTPPNTTPIKNGS CCCCCCCCCCCCCCC	39.46	21082442
115	Phosphorylation	IGTPPNTTPIKNGSP CCCCCCCCCCCCCCC	29.65	27087446
121	Phosphorylation	TTPIKNGSPEIKLKI CCCCCCCCCCCEEEE	28.84	22942356
141	Phosphorylation	NGKPLFESSICGDGA CCEECEECCCCCCCC	20.05	25266776
142	Phosphorylation	GKPLFESSICGDGAA CEECEECCCCCCCCC	18.07	25266776
172	Phosphorylation	TRRNRKRSIKYDSLL HHHHHHHHHHHHHHH	26.85	26745281
175	Phosphorylation	NRKRSIKYDSLLEQG HHHHHHHHHHHHHCC	14.75	21183079
177	Phosphorylation	KRSIKYDSLLEQGLV HHHHHHHHHHHCCHH	31.59	26745281
193	Phosphorylation	AALVSKISSPADKKI HHHHHHCCCCCCCCC	33.72	26745281
194	Phosphorylation	ALVSKISSPADKKIP HHHHHCCCCCCCCCC	27.81	26745281
376	Phosphorylation	PLGEMVDSSGASEEA ECCCCCCCCCCCCCC	21.18	-
389	Phosphorylation	EAAVDPGSVREEDIP CCCCCCCCCCCCCCC	24.32	29514104
406	Phosphorylation	RRRRTKRSSSAENQE HHHCCCCCCCCCCCC	30.15	27087446
407	Phosphorylation	RRRTKRSSSAENQEG HHCCCCCCCCCCCCC	37.29	25521595
408	Phosphorylation	RRTKRSSSAENQEGD HCCCCCCCCCCCCCC	40.63	25521595
418	Phosphorylation	NQEGDPGTDKSTPPK CCCCCCCCCCCCCCC	45.72	26745281
421	Phosphorylation	GDPGTDKSTPPKMAE CCCCCCCCCCCCHHC	49.29	17242355
422	Phosphorylation	DPGTDKSTPPKMAEA CCCCCCCCCCCHHCC	49.72	19060867
437	Phosphorylation	EPKRGVGSPAGRKKS CCCCCCCCCCCCCCC	14.79	26824392
507	Phosphorylation	ARYNTKFSLMISAQS HHHCCCEEEEEEECC	20.70	25159016
511	Phosphorylation	TKFSLMISAQSEEDS CCEEEEEEECCCCCC	13.29	25159016
514	Phosphorylation	SLMISAQSEEDSGNG EEEEEECCCCCCCCC	42.54	25159016
518	Phosphorylation	SAQSEEDSGNGNGKK EECCCCCCCCCCCCC	37.12	25159016
579	Phosphorylation	YKAIEAASSLKSQAA HHHHHHHHHHHHHHH	43.16	29176673
580	Phosphorylation	KAIEAASSLKSQAAT HHHHHHHHHHHHHHH	34.78	29176673
583	Phosphorylation	EAASSLKSQAATKNL HHHHHHHHHHHHCCH	30.28	29176673
604	Phosphorylation	LKKRNRASATASSAL HHHCCCHHHHHHHHH	23.94	28066266
606	Phosphorylation	KRNRASATASSALGF HCCCHHHHHHHHHCC	25.28	28066266
608	Phosphorylation	NRASATASSALGFNK CCHHHHHHHHHCCCC	16.28	28066266
609	Phosphorylation	RASATASSALGFNKS CHHHHHHHHHCCCCC	25.67	28066266
616	Phosphorylation	SALGFNKSSSPSASL HHHCCCCCCCCCCCC	36.83	30635358
617	Phosphorylation	ALGFNKSSSPSASLT HHCCCCCCCCCCCCC	48.13	30635358
618	Phosphorylation	LGFNKSSSPSASLTE HCCCCCCCCCCCCCC	29.93	30635358
620	Phosphorylation	FNKSSSPSASLTEHE CCCCCCCCCCCCCEE	32.22	30635358
622	Phosphorylation	KSSSPSASLTEHEVS CCCCCCCCCCCEECC	39.91	30635358
624	Phosphorylation	SSPSASLTEHEVSDS CCCCCCCCCEECCCC	32.57	30635358
629	Phosphorylation	SLTEHEVSDSPGDEP CCCCEECCCCCCCCC	29.41	30635358
631	Phosphorylation	TEHEVSDSPGDEPSE CCEECCCCCCCCCCC	24.23	30635358
637	Phosphorylation	DSPGDEPSESPYESA CCCCCCCCCCCCCCC	48.97	30635358
639	Phosphorylation	PGDEPSESPYESADE CCCCCCCCCCCCCCC	36.80	22802335
641	Phosphorylation	DEPSESPYESADETQ CCCCCCCCCCCCCCC	31.62	30635358
643	Phosphorylation	PSESPYESADETQTE CCCCCCCCCCCCCCC	34.87	22668510
647	Phosphorylation	PYESADETQTEASVS CCCCCCCCCCCHHHH	41.14	30635358
649	Phosphorylation	ESADETQTEASVSSK CCCCCCCCCHHHHCC	40.72	30635358
652	Phosphorylation	DETQTEASVSSKKSE CCCCCCHHHHCCCCH	19.12	30635358
1070	Phosphorylation	PETKIIKTDGKGWGL CCCEEEECCCCCCEE	39.31	-
1211	Phosphorylation	DRPKTSASLSSEEKG CCCCCCCCCCHHHHH	28.66	27841257

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSD2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSD2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSD2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H32_HUMAN	HIST2H3C	physical	19483677
SMCA4_MOUSE	Smarca4	physical	19483677
HNRPU_MOUSE	Hnrnpu	physical	19483677
OGT1_MOUSE	Ogt	physical	19483677
RAVR1_MOUSE	Raver1	physical	19483677
SALL4_MOUSE	Sall4	physical	19483677
RPB1_MOUSE	Polr2a	physical	19483677
HDAC1_MOUSE	Hdac1	physical	19483677
NANOG_MOUSE	Nanog	physical	19483677

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.