dbPTM

NIPBL_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NIPBL_MOUSE
UniProt AC	Q6KCD5
Protein Name	Nipped-B-like protein
Gene Name	Nipbl
Organism	Mus musculus (Mouse).
Sequence Length	2798
Subcellular Localization	Nucleus . Chromosome .
Protein Description	Plays an important role in the loading of the cohesin complex on to DNA. [PubMed: 29094699 Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitement to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitement to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (By similarity Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others]
Protein Sequence	MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNSRIAEEVNCLLACRDDNLVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSDDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSDGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKIKLGKDEKDQNEKAAMYDIISSPTKDSTKLTLRLSRVRSSDMDQQDDMLSGMENSNVSENDIPFNVQYPGQTSKTPITPQDVNRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVATKQPQTSVVQNQQQVSQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEETKQCNDAPISVLQEDIVGSLKSIPENHPETPKKKSDPELSKSEMKQNESRLSESKPNENQLGESKSNESKLETKTETPTEELKQNENKTTESKQSESAVVEPKQNENRPCDTKPNDNKQNNTRSENTKARPETPKQKAESRPETPKQKSEGRPETPKQKGDGRPETPKQKSEGRPETPKQKGEGRPETPKHRHENRRDSGKPSTEKKPDVSKHKQDIKSDSPRLKSERAEALKQRPDGRWESLRRDHDSKQKSDDRGESERHRGDQSRVRRPETLRSSSRNDHSTKSDGSKTEKLERKHRHESGDSRDRPSGEQKSRPDSPRVKQGDTNKSRPGFKSPNSKDDKRTEGNRSKVDSNKAHTDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNITQETKKMDMKGEQKDKVEKMGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREEKSRSSLKSIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHDGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRVDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTAVFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDVDGEPMYIQMVTALVLQLIQCVVHLPSSEKDPNSEEDSNKKVDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARLRKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSDATHHAKELETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNSILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTEVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKTSPAKENESSESEEEVSRPRKSRKRVDSESDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKLTEDVKRSIVRQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAADTEDEESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQRTSSGVSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAAKDGTSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Phosphorylation	LVSQLVHSLNQVSTD HHHHHHHHHHHCCCC	22.87	21183079
73	Phosphorylation	VHSLNQVSTDHIELK HHHHHHCCCCCEEEH	20.53	22817900
74	Phosphorylation	HSLNQVSTDHIELKD HHHHHCCCCCEEEHH	32.51	21183079
85	Phosphorylation	ELKDNLGSDDPEGDI EEHHCCCCCCCCCCH	41.84	26525534
103	Phosphorylation	LQAVLARSPNVFREK HHHHHHCCCCCHHCH	18.41	26745281
129	Phosphorylation	MMSQYKLSQNSMHSS HHHHHHCCCCCCCCC	24.14	25777480
132	Phosphorylation	QYKLSQNSMHSSPAS HHHCCCCCCCCCCCC	15.38	25777480
135	Phosphorylation	LSQNSMHSSPASSNY CCCCCCCCCCCCCCC	29.40	26643407
136	Phosphorylation	SQNSMHSSPASSNYQ CCCCCCCCCCCCCCC	15.14	26643407
139	Phosphorylation	SMHSSPASSNYQQTT CCCCCCCCCCCCCCC	23.62	25777480
140	Phosphorylation	MHSSPASSNYQQTTI CCCCCCCCCCCCCCC	41.48	25777480
142	Phosphorylation	SSPASSNYQQTTISH CCCCCCCCCCCCCCC	12.16	25777480
145	Phosphorylation	ASSNYQQTTISHSPS CCCCCCCCCCCCCCC	15.57	25777480
146	Phosphorylation	SSNYQQTTISHSPSS CCCCCCCCCCCCCCC	19.02	25777480
148	Phosphorylation	NYQQTTISHSPSSRF CCCCCCCCCCCCCCC	18.80	26643407
150	Phosphorylation	QQTTISHSPSSRFVP CCCCCCCCCCCCCCC	21.49	21082442
152	Phosphorylation	TTISHSPSSRFVPPQ CCCCCCCCCCCCCCC	36.84	26643407
153	Phosphorylation	TISHSPSSRFVPPQT CCCCCCCCCCCCCCC	32.87	26643407
162	Phosphorylation	FVPPQTSSGNRFMPQ CCCCCCCCCCCCCCC	43.40	-
172	Phosphorylation	RFMPQQNSPVPSPYA CCCCCCCCCCCCCCC	23.96	22802335
193	Phosphorylation	YMPYSHPSSYTTHPQ CCCCCCCCCCCCCCH	30.47	22802335
194	Phosphorylation	MPYSHPSSYTTHPQM CCCCCCCCCCCCCHH	30.83	22802335
195	Phosphorylation	PYSHPSSYTTHPQMQ CCCCCCCCCCCCHHH	21.72	22802335
196	Phosphorylation	YSHPSSYTTHPQMQQ CCCCCCCCCCCHHHH	22.15	22802335
197	Phosphorylation	SHPSSYTTHPQMQQA CCCCCCCCCCHHHHC	24.27	22802335
205	Phosphorylation	HPQMQQASVSSPIVA CCHHHHCCCCCCEEE	20.42	22802335
207	Phosphorylation	QMQQASVSSPIVAGG HHHHCCCCCCEEECC	28.09	22802335
208	Phosphorylation	MQQASVSSPIVAGGL HHHCCCCCCEEECCC	19.25	22802335
228	Phosphorylation	NKVSGPLSGNSANHH CCCCCCCCCCCCCCC	38.78	25338131
243	Phosphorylation	ADNPRHGSSDDYLHM CCCCCCCCCHHHHHH	25.19	25266776
244	Phosphorylation	DNPRHGSSDDYLHMV CCCCCCCCHHHHHHH	38.81	24719451
255	Phosphorylation	LHMVHRLSSDDGDSS HHHHHHHCCCCCCCH	31.51	28833060
256	Phosphorylation	HMVHRLSSDDGDSST HHHHHHCCCCCCCHH	44.29	27742792
261	Phosphorylation	LSSDDGDSSTMRNAA HCCCCCCCHHHHCCC	32.98	27742792
262	Phosphorylation	SSDDGDSSTMRNAAS CCCCCCCHHHHCCCC	30.84	27742792
263	Phosphorylation	SDDGDSSTMRNAASF CCCCCCHHHHCCCCC	24.89	27742792
269	Phosphorylation	STMRNAASFPLRSPQ HHHHCCCCCCCCCCC	25.61	25619855
274	Phosphorylation	AASFPLRSPQPVCSP CCCCCCCCCCCCCCC	35.25	27087446
280	Phosphorylation	RSPQPVCSPAGSDGT CCCCCCCCCCCCCCC	20.30	25521595
284	Phosphorylation	PVCSPAGSDGTPKGS CCCCCCCCCCCCCCC	34.67	25521595
287	Phosphorylation	SPAGSDGTPKGSRPP CCCCCCCCCCCCCCC	27.15	22942356
299	Phosphorylation	RPPLILQSQSLPCSS CCCEEEECCCCCCCC	20.49	25619855
301	Phosphorylation	PLILQSQSLPCSSPR CEEEECCCCCCCCCC	39.25	27742792
305	Phosphorylation	QSQSLPCSSPRDVPP ECCCCCCCCCCCCCC	41.24	27742792
306	Phosphorylation	SQSLPCSSPRDVPPD CCCCCCCCCCCCCCC	30.58	25521595
318	Phosphorylation	PPDILLDSPERKQKK CCCCCCCCHHHHHHH	28.73	25521595
345	Phosphorylation	QNEKAAMYDIISSPT HHHHHHHHHHHHCCC	10.16	25619855
349	Phosphorylation	AAMYDIISSPTKDST HHHHHHHHCCCCCCC	30.51	23375375
350	Phosphorylation	AMYDIISSPTKDSTK HHHHHHHCCCCCCCH	26.61	25521595
352	Phosphorylation	YDIISSPTKDSTKLT HHHHHCCCCCCCHHE	49.81	22942356
355	Phosphorylation	ISSPTKDSTKLTLRL HHCCCCCCCHHEEEH	29.06	25619855
356	Phosphorylation	SSPTKDSTKLTLRLS HCCCCCCCHHEEEHH	39.96	25619855
363	Phosphorylation	TKLTLRLSRVRSSDM CHHEEEHHHHHCCCC	23.46	-
367	Phosphorylation	LRLSRVRSSDMDQQD EEHHHHHCCCCCCHH	28.03	26643407
368	Phosphorylation	RLSRVRSSDMDQQDD EHHHHHCCCCCCHHH	26.79	24453211
378	Phosphorylation	DQQDDMLSGMENSNV CCHHHHHHCCCCCCC	29.47	21183079
383	Phosphorylation	MLSGMENSNVSENDI HHHCCCCCCCCCCCC	25.88	21183079
403	Phosphorylation	YPGQTSKTPITPQDV CCCCCCCCCCCHHHC	21.49	22006019
406	Phosphorylation	QTSKTPITPQDVNRP CCCCCCCCHHHCCCC	18.99	26060331
484	Phosphorylation	IERIERESAIERERF HHHHHHHHHHHHHHH	40.54	29176673
498	Acetylation	FSKEVQDKDKPLKKR HHHHHCCCCCCCHHH	51.03	23806337
553	Phosphorylation	HQAGRVDSQASITQD HHCCCCCCCCCCCCC	25.45	17525332
556	Phosphorylation	GRVDSQASITQDSDS CCCCCCCCCCCCCCC	20.66	30352176
558	Phosphorylation	VDSQASITQDSDSIK CCCCCCCCCCCCCCC	24.67	17525332
591	Phosphorylation	DIVGSLKSIPENHPE HHHHHHHCCCCCCCC	48.98	28285833
599	Phosphorylation	IPENHPETPKKKSDP CCCCCCCCCCCCCCH	44.88	26824392
621	Phosphorylation	KQNESRLSESKPNEN HHHHHHHCCCCCCCC	38.42	25338131
635	Phosphorylation	NQLGESKSNESKLET CCCCCCCCCHHHCCC	55.92	28973931
642	Phosphorylation	SNESKLETKTETPTE CCHHHCCCCCCCCHH	54.42	23984901
644	Phosphorylation	ESKLETKTETPTEEL HHHCCCCCCCCHHHH	53.14	25619855
646	Phosphorylation	KLETKTETPTEELKQ HCCCCCCCCHHHHHH	40.52	26824392
648	Phosphorylation	ETKTETPTEELKQNE CCCCCCCHHHHHHCC	49.89	23984901
658	Phosphorylation	LKQNENKTTESKQSE HHHCCCCCCCCHHHC	47.58	22871156
659	Phosphorylation	KQNENKTTESKQSES HHCCCCCCCCHHHCC	39.61	22871156
702	Phosphorylation	NTKARPETPKQKAES CCCCCCCCHHHHHHC	38.17	23684622
709	Phosphorylation	TPKQKAESRPETPKQ CHHHHHHCCCCCCCC	58.98	23684622
713	Phosphorylation	KAESRPETPKQKSEG HHHCCCCCCCCCCCC	38.17	25266776
718	Phosphorylation	PETPKQKSEGRPETP CCCCCCCCCCCCCCC	42.67	25266776
724	Phosphorylation	KSEGRPETPKQKGDG CCCCCCCCCCCCCCC	38.17	26824392
735	Phosphorylation	KGDGRPETPKQKSEG CCCCCCCCCCCCCCC	38.17	25521595
746	Phosphorylation	KSEGRPETPKQKGEG CCCCCCCCCCCCCCC	38.17	27600695
757	Phosphorylation	KGEGRPETPKHRHEN CCCCCCCCCCCCCCC	40.08	25263469
768	Phosphorylation	RHENRRDSGKPSTEK CCCCCCCCCCCCCCC	47.07	25266776
788	Phosphorylation	KHKQDIKSDSPRLKS HHHHHHCCCCHHHHH	43.59	30635358
790	Phosphorylation	KQDIKSDSPRLKSER HHHHCCCCHHHHHHH	21.00	24719451
872	Phosphorylation	ERKHRHESGDSRDRP HHHHCCCCCCCCCCC	41.60	26824392
875	Phosphorylation	HRHESGDSRDRPSGE HCCCCCCCCCCCCCC	39.34	30635358
885	Phosphorylation	RPSGEQKSRPDSPRV CCCCCCCCCCCCCCC	49.06	23140645
889	Phosphorylation	EQKSRPDSPRVKQGD CCCCCCCCCCCCCCC	19.79	24453211
906	Phosphorylation	KSRPGFKSPNSKDDK CCCCCCCCCCCCCCC	27.36	25266776
909	Phosphorylation	PGFKSPNSKDDKRTE CCCCCCCCCCCCCCC	40.63	25266776
994	Acetylation	EDLNKGAKPVVVLQK HHHCCCCCCEEEEEE	47.19	23954790
1009	Acetylation	LSLDDVQKLIKDREE CCHHHHHHHHHCHHH	52.61	22826441
1012	Ubiquitination	DDVQKLIKDREEKSR HHHHHHHHCHHHHHH	62.26	27667366
1018	Phosphorylation	IKDREEKSRSSLKSI HHCHHHHHHHHHHHH	40.45	-
1020	Phosphorylation	DREEKSRSSLKSIKN CHHHHHHHHHHHHHC	47.30	-
1024	Phosphorylation	KSRSSLKSIKNKPSK HHHHHHHHHHCCCCC	44.05	-
1032	Phosphorylation	IKNKPSKSNKGSIDQ HHCCCCCCCCCCCCH	48.38	28285833
1034	Ubiquitination	NKPSKSNKGSIDQSV CCCCCCCCCCCCHHH	62.21	22790023
1036	Phosphorylation	PSKSNKGSIDQSVLK CCCCCCCCCCHHHHH	25.30	27841257
1071	Phosphorylation	KMNKRKRSTVNEKPK HCCCCCCCCCCCCCC	39.48	23684622
1072	Phosphorylation	MNKRKRSTVNEKPKY CCCCCCCCCCCCCCC	31.23	28059163
1076	Acetylation	KRSTVNEKPKYAEIS CCCCCCCCCCCCCCC	41.42	23806337
1079	Phosphorylation	TVNEKPKYAEISSDE CCCCCCCCCCCCCCC	20.28	23429704
1083	Phosphorylation	KPKYAEISSDEDNDS CCCCCCCCCCCCCCC	24.20	27087446
1084	Phosphorylation	PKYAEISSDEDNDSD CCCCCCCCCCCCCCH	51.16	27087446
1090	Phosphorylation	SSDEDNDSDEAFESS CCCCCCCCHHHHHHH	43.54	27087446
1096	Phosphorylation	DSDEAFESSRKRHKK CCHHHHHHHHHHHCC	29.05	21149613
1097	Phosphorylation	SDEAFESSRKRHKKD CHHHHHHHHHHHCCC	34.32	21149613
1144	Phosphorylation	GGRYRNRSPSDSDME CCCCCCCCCCCCCCC	32.10	21082442
1146	Phosphorylation	RYRNRSPSDSDMEDY CCCCCCCCCCCCCCC	51.50	21082442
1148	Phosphorylation	RNRSPSDSDMEDYSP CCCCCCCCCCCCCCC	43.10	21082442
1153	Phosphorylation	SDSDMEDYSPPPSLS CCCCCCCCCCCCCHH	15.12	21149613
1154	Phosphorylation	DSDMEDYSPPPSLSE CCCCCCCCCCCCHHH	43.16	21082442
1183	Phosphorylation	KAYEPKLTPEEMMDS HHCCCCCCHHHHCCH	34.48	-
1191	Phosphorylation	PEEMMDSSTFKRFTA HHHHCCHHHHHHHHH	33.33	-
1194	Ubiquitination	MMDSSTFKRFTASIE HCCHHHHHHHHHHHH	46.84	22790023
1452	Phosphorylation	LILEEIFTSLARLPT HHHHHHHHHHHCCCC	28.61	19144319
1453	Phosphorylation	ILEEIFTSLARLPTS HHHHHHHHHHCCCCC	14.85	19144319
1459	Phosphorylation	TSLARLPTSKRSLRN HHHHCCCCCHHHHHC	52.01	21454597
1603	Phosphorylation	EMALRVASLDYLGTV HHHHHHHCHHHHHHH	20.93	26643407
1606	Phosphorylation	LRVASLDYLGTVAAR HHHHCHHHHHHHHHH	16.60	26643407
1609	Phosphorylation	ASLDYLGTVAARLRK HCHHHHHHHHHHHHH	12.36	26643407
1727	Phosphorylation	FLRSIIKTTPSQFST HHHHHHHCCHHHHCC	33.27	26643407
1728	Phosphorylation	LRSIIKTTPSQFSTL HHHHHHCCHHHHCCC	18.88	26643407
1730	Phosphorylation	SIIKTTPSQFSTLKM HHHHCCHHHHCCCCC	41.59	26643407
1733	Phosphorylation	KTTPSQFSTLKMNSD HCCHHHHCCCCCCCC	25.78	26643407
1885	Ubiquitination	KITEMCVKMIRRVND HHHHHHHHHHHHCCC	24.55	22790023
2210	Phosphorylation	EQEVKNLYNSILSDK HHHHHHHHHHHHCCC	19.09	22817900
2212	Phosphorylation	EVKNLYNSILSDKNS HHHHHHHHHHCCCCC	16.02	21183079
2219	Phosphorylation	SILSDKNSSVNLKIQ HHHCCCCCCHHHHHH	41.21	22802335
2220	Phosphorylation	ILSDKNSSVNLKIQV HHCCCCCCHHHHHHH	25.15	22802335
2276	Phosphorylation	SSSIMQLYLKQVLEA CHHHHHHHHHHHHHH	8.58	28576409
2476	Phosphorylation	DKRKERKTSPAKENE HHHHHCCCCCCCCCC	46.28	25159016
2477	Phosphorylation	KRKERKTSPAKENES HHHHCCCCCCCCCCC	26.37	21659605
2484	Phosphorylation	SPAKENESSESEEEV CCCCCCCCCCCHHHH	51.49	25521595
2485	Phosphorylation	PAKENESSESEEEVS CCCCCCCCCCHHHHC	38.67	25521595
2487	Phosphorylation	KENESSESEEEVSRP CCCCCCCCHHHHCCC	52.86	25521595
2492	Phosphorylation	SESEEEVSRPRKSRK CCCHHHHCCCCHHHC	39.59	25159016
2503	Phosphorylation	KSRKRVDSESDSDSE HHHCCCCCCCCCCCH	35.82	27087446
2505	Phosphorylation	RKRVDSESDSDSEDD HCCCCCCCCCCCHHH	46.49	27087446
2507	Phosphorylation	RVDSESDSDSEDDIN CCCCCCCCCCHHHHH	52.92	27087446
2509	Phosphorylation	DSESDSDSEDDINSV CCCCCCCCHHHHHHH	47.04	23684622
2515	Phosphorylation	DSEDDINSVMKCLPE CCHHHHHHHHHHCCC	24.75	30635358
2645	Phosphorylation	NARNKAITSLLGGGS HHHHHHHHHHHCCCC	20.41	25619855
2645 (in isoform 2)	Phosphorylation	-	20.41	30635358
2646	Phosphorylation	ARNKAITSLLGGGSP HHHHHHHHHHCCCCC	18.58	24925903
2646 (in isoform 2)	Phosphorylation	-	18.58	30635358
2652	Phosphorylation	TSLLGGGSPKNNTAA HHHHCCCCCCCCCCC	35.66	24925903
2652 (in isoform 2)	Phosphorylation	-	35.66	24759943
2657	Phosphorylation	GGSPKNNTAADTEDE CCCCCCCCCCCCCCC	32.39	23429704
2657 (in isoform 2)	Phosphorylation	-	32.39	25159016
2661	Phosphorylation	KNNTAADTEDEESDG CCCCCCCCCCCCCCC	40.38	25521595
2661 (in isoform 2)	Phosphorylation	-	40.38	25263469
2666	Phosphorylation	ADTEDEESDGEDRGG CCCCCCCCCCCCCCC	49.20	25521595
2666 (in isoform 2)	Phosphorylation	-	49.20	26824392
2675	Phosphorylation	GEDRGGGTSGSLRRS CCCCCCCCCHHHCCH	32.94	25159016
2675 (in isoform 2)	Phosphorylation	-	32.94	25159016
2676	Phosphorylation	EDRGGGTSGSLRRSK CCCCCCCCHHHCCHH	29.65	25159016
2676 (in isoform 2)	Phosphorylation	-	29.65	25159016
2678	Phosphorylation	RGGGTSGSLRRSKRN CCCCCCHHHCCHHCC	20.62	25159016
2683 (in isoform 2)	Phosphorylation	-	54.51	22802335
2687 (in isoform 2)	Phosphorylation	-	64.23	29514104
2725	Phosphorylation	IARVVQRTSSGVSVQ HHHHHHHCCCCCEEE	15.34	29895711
2726	Phosphorylation	ARVVQRTSSGVSVQW HHHHHHCCCCCEEEE	27.55	29895711
2730	Phosphorylation	QRTSSGVSVQWMAGS HHCCCCCEEEEECCC	16.47	28059163
2737	Phosphorylation	SVQWMAGSYSGSWTE EEEEECCCCCCCCCC	13.44	28059163
2738	Phosphorylation	VQWMAGSYSGSWTEA EEEECCCCCCCCCCC	19.01	29895711
2739	Phosphorylation	QWMAGSYSGSWTEAK EEECCCCCCCCCCCH	28.22	29895711
2741	Phosphorylation	MAGSYSGSWTEAKRR ECCCCCCCCCCCHHC	25.53	29895711
2759	Phosphorylation	KLVPWVDTIKESDII CCCCHHHCCCHHHHH	25.08	20469934

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NIPBL_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NIPBL_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NIPBL_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMA7_HUMAN	KPNA6	physical	20360068
IMA5_HUMAN	KPNA1	physical	20360068
NIPBL_HUMAN	NIPBL	physical	20360068
MAML1_HUMAN	MAML1	physical	26496610
IASPP_HUMAN	PPP1R13L	physical	26496610
KLC2_HUMAN	KLC2	physical	26496610
BRAT1_HUMAN	BRAT1	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NIPBL_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1452; SER-1453 ANDSER-2652, AND MASS SPECTROMETRY.	19144319 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553 AND THR-558, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; THR-2661 ANDSER-2666, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2666, AND MASSSPECTROMETRY.	17203969 [Abstract]