WDR43_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR43_MOUSE
• UniProt AC: Q6ZQL4
• Protein Name: WD repeat-containing protein 43
• Gene Name: Wdr43
• Organism: Mus musculus (Mouse).
• Sequence Length: 677
• Subcellular Localization: Nucleus, nucleolus . Found predominantly at the fibrillar center.
• Protein Description: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I..
• Protein Sequence: MAAGGGGSYDPLAPAGVPCAFSPDSQAYFALASSDGQLRVWETANNRLHQEYVPSAHLSGTCTCLAWAPARLQAKESHQRKKRKSEVTGTKDQADLLALGTAVGSILLYSTVRGELHSKLTSGGHENRVNCIQWHQDNDCLYSCSDDKYIVEWSTQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVYRHFTGHATPVSSLRFTTIRPNESQPSDGITGLYFLSGAVHDRLLNVWQVRSENKEKSAVMSFTVTDEPVYVDLTLSENKEEPVKLAVVCRDGQVHLFEHILNGHCKKPLTSNCTIQIATPGKGKKVTPKPIPILAASFCLDKMSLLLVYGNWFQPTIERVALNSKDTHICLERDISNCWAPTVETAITKVKTPVMNSEAKVLVPGIPGHHAPIKLPPAQPKEAENKRKLGSTEATIEERLGAMDLDRKGRKDDLQTNSFAVLLTQGLESNDFEILNKVLQTKNVNLIKRTVLRIPLRVVIPLLQELTKRLQGHPNSAALMIQWLKCVLTIHASYLSTLPDLVEQLGTLYQLMESRVKTFQKLSNLHGKLILLVTQVTASEKSKKMTSPGQKAKLVYEEESSEEESDDEVPEKDSDDNWDEDEDKDSEKDEGVDEDNEEEDEDMEDKEENEEDREVSSEKELNGDSDLDPENESEEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	ARLQAKESHQRKKRK HHHHHHHHHHHHHHH	24.98	-
85	Phosphorylation	HQRKKRKSEVTGTKD HHHHHHHHHCCCCHH	41.13	26824392
320	Phosphorylation	NCTIQIATPGKGKKV CCEEEEECCCCCCCC	33.91	26643407
393	Phosphorylation	TAITKVKTPVMNSEA HHHHCCCCCCCCCCC	24.89	25159016
398	Phosphorylation	VKTPVMNSEAKVLVP CCCCCCCCCCEEECC	22.34	-
432	Phosphorylation	ENKRKLGSTEATIEE HHHHCCCCCHHHHHH	33.25	26824392
433	Phosphorylation	NKRKLGSTEATIEER HHHCCCCCHHHHHHH	28.04	28833060
436	Phosphorylation	KLGSTEATIEERLGA CCCCCHHHHHHHHCC	23.77	28833060
587	Phosphorylation	SEKSKKMTSPGQKAK CHHHCCCCCCCCEEE	40.42	28066266
588	Phosphorylation	EKSKKMTSPGQKAKL HHHCCCCCCCCEEEE	24.43	26824392
597	Phosphorylation	GQKAKLVYEEESSEE CCEEEEEEECCCCCC	28.23	25195567
601	Phosphorylation	KLVYEEESSEEESDD EEEEECCCCCCCCCC	46.45	22817900
602	Phosphorylation	LVYEEESSEEESDDE EEEECCCCCCCCCCC	52.92	22817900
606	Phosphorylation	EESSEEESDDEVPEK CCCCCCCCCCCCCCC	54.35	22817900
615	Phosphorylation	DEVPEKDSDDNWDED CCCCCCCCCCCCCCC	58.91	22817900
627	Phosphorylation	DEDEDKDSEKDEGVD CCCCCCCCCCCCCCC	52.89	25195567
657	Phosphorylation	NEEDREVSSEKELNG CHHHHHHHHHHHHCC	28.20	25521595
658	Phosphorylation	EEDREVSSEKELNGD HHHHHHHHHHHHCCC	58.84	25521595
666	Phosphorylation	EKELNGDSDLDPENE HHHHCCCCCCCCCCC	41.28	25521595
674	Phosphorylation	DLDPENESEEE---- CCCCCCCCCCC----	62.99	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR43_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR43_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR43_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of WDR43_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-657 AND SER-658, ANDMASS SPECTROMETRY.
PubMed: 19367708