dbPTM

DDX41_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDX41_MOUSE
UniProt AC	Q91VN6
Protein Name	Probable ATP-dependent RNA helicase DDX41
Gene Name	Ddx41
Organism	Mus musculus (Mouse).
Sequence Length	622
Subcellular Localization	Nucleus .
Protein Description	Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing..
Protein Sequence	MEDSEPERKRARADEATAGGSRSEDEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGATEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEDSEPERKRA ----CCCCHHHHHHH	41.57	26824392
9	Ubiquitination	EDSEPERKRARADEA CCCHHHHHHHHHHHC	49.07	-
17	Phosphorylation	RARADEATAGGSRSE HHHHHHCCCCCCCCC	24.64	21082442
21	Phosphorylation	DEATAGGSRSEDEDE HHCCCCCCCCCCCCC	31.54	25521595
23	Phosphorylation	ATAGGSRSEDEDEDD CCCCCCCCCCCCCCC	51.61	25521595
33	Phosphorylation	EDEDDEDYVPYVPLR CCCCCCCCCCCCCHH	10.98	22802335
36	Phosphorylation	DDEDYVPYVPLRQRR CCCCCCCCCCHHHHH	12.49	25619855
59	Phosphorylation	QRRRKGATEEEQQDS HHHHCCCCHHHHHCC	53.23	25159016
66	Phosphorylation	TEEEQQDSGSEPRGD CHHHHHCCCCCCCCC	39.62	25521595
68	Phosphorylation	EEQQDSGSEPRGDED HHHHCCCCCCCCCCC	48.67	27087446
83	Phosphorylation	DIPLGPQSNVSLLDQ CCCCCCCCCCHHHHH	42.19	25159016
86	Phosphorylation	LGPQSNVSLLDQHQH CCCCCCCHHHHHHHH	27.71	25159016
115	Ubiquitination	KQLKEEEKILESVAE HHHHHHHHHHHHHHH	56.74	-
288	Phosphorylation	CRLLQEDSSPLLRCA HHHHHCCCCHHHHHH	32.86	23737553
289	Phosphorylation	RLLQEDSSPLLRCAL HHHHCCCCHHHHHHH	31.71	23737553
493	Phosphorylation	LVATDVASKGLDFPA EEEEHHHCCCCCCCH	27.40	22817900
607	Phosphorylation	AMQTKQVSNIGRKDY HHHCCCCCCCCCCHH	21.89	21930439
618	Phosphorylation	RKDYLAHSSMDF--- CCHHHHHCCCCC---	23.04	19854140
619	Phosphorylation	KDYLAHSSMDF---- CHHHHHCCCCC----	16.71	30482847

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DDX41_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDX41_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDX41_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NKAP_HUMAN	NKAP	physical	20360068
DDX41_HUMAN	DDX41	physical	20360068

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDX41_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-17 AND SER-21, AND MASSSPECTROMETRY.	17242355 [Abstract]