CTU1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTU1_MOUSE
• UniProt AC: Q99J10
• Protein Name: Cytoplasmic tRNA 2-thiolation protein 1 {ECO:0000255|HAMAP-Rule:MF_03053}
• Gene Name: Ctu1
• Organism: Mus musculus (Mouse).
• Sequence Length: 420
• Subcellular Localization: Cytoplasm .
• Protein Description: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position..
• Protein Sequence: MPAPTCFSCHKTRAALRRPRSGQALCGSCFCAAFEAEVLHTVLAGHLLPPGAVVAVGASGGKDSTVLAHVLRELAPRLGITLHLVAVDEGIGGYRDAALEAVRSQAARWELPLTIVAYEDLFGGWTMDAVARSTAGSGRSRSCCTFCGVLRRRALEEGARLVGATHIVTGHNADDMAETVLMNFLRGDAGRLARGGVLGSTGEGCALPRCRPLQFASQKEVVLYAHFRHLRYFSEECVYAPEAFRGHARDLLKLLEAARPSAVLDLVHSAERLALAPAAKPPPPGTCSRCGALASHKLCQACALLDGLNRGLPRLAIGKGRRVLQVEPPQPGNPSLVTSDPVAPAGPCTCKQPKDKANPCGNGGDRAGATCVSQCDLSPGNGEDRAGATCVSQRDLSLGNGGDRAGATCVSQCDLSPVAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
200	Phosphorylation	ARGGVLGSTGEGCAL HCCCCCCCCCCCCCC	29.13	-
370	Phosphorylation	GGDRAGATCVSQCDL CCCCCCCEEEEECCC	16.72	30635358
373	Phosphorylation	RAGATCVSQCDLSPG CCCCEEEEECCCCCC	27.51	30635358
378	Phosphorylation	CVSQCDLSPGNGEDR EEEECCCCCCCCCCC	19.94	27087446
390	Glutathionylation	EDRAGATCVSQRDLS CCCCCCEEEECCCCC	2.48	24333276
408	Phosphorylation	GGDRAGATCVSQCDL CCCCCCCEEEECCCC	16.72	28066266
411	Phosphorylation	RAGATCVSQCDLSPV CCCCEEEECCCCCCC	27.51	25619855
416	Phosphorylation	CVSQCDLSPVAE--- EEECCCCCCCCC---	12.22	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTU1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTU1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTU1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CTU1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.