MRCKG_MOUSE - dbPTM
MRCKG_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MRCKG_MOUSE
UniProt AC Q80UW5
Protein Name Serine/threonine-protein kinase MRCK gamma
Gene Name Cdc42bpg {ECO:0000312|MGI:MGI:2652845}
Organism Mus musculus (Mouse).
Sequence Length 1551
Subcellular Localization Cytoplasm. Concentrates at the leading edge of cells..
Protein Description May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity)..
Protein Sequence MEQRLRALEQLVRGEAGGSPGLDGLLDLLLGVHQELSSAPLRRERNVAQFLSWASPFVTKVKELRLQRDDFEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPADVTDVPASAQDLIRQLLCRQEERLGRGGLDDFRKHPFFEGVDWERLATSTAPYIPELRGPMDTSNFDVDDDTLNRPETLPPSSHGAFSGHHLPFVGFTYTSGSPFDVQSSELMAAPEGTPHCVEQVKVELSHKCQEPLHGPLQPQELVRLQKEVQVLQEKLAETLRDSKASLSQTDGLHARSPAPNIQLQQEKDRLQQELTEAQAALRVQDAELCQAQNRQEEFLQRLWEAQEREAAAASQIQALNSQLEEAWVVRRELEGQVTTLSQEVTRLQGQCKQESSQAKTVHAAPETNGIGSPEGQSQEAQLRKEVAALREQLEHACSQGISVGKEEVLCRLQEENQRLSREQERLAGELELELQSKQRLEGERRETESNWEAQIADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPTRPLDHQWKARRLQKMEASARLELQSALEAEIRAKQSLQEQLTQVQEAQRQAERRLQEAEKQSQALQQEVAELREELQARGPGDARPSTSLIPLLSFWNTEKDSAKDPGNSGEGPRSGAEAELRPEGRRSLRMGSVFPRVPAATTTPAEGPPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDTCGYFCHSACASQAPPCPVPPELLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVYAALSDSRLLLFDAPDPRGSLASGVLLQALDLRDPQFSATPVLAPDVIHAQSKDLPRIFRVTASQLTVPPTTCTVLLLAENEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHALCAAVIDQERLALGTEEGLFVIHLHSNDIFQVGDCRRVQRLAVSSAAGLLAVLCGRGPSVRLFALDELESAEVAGAKIPESRGCQALVAGRILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPAPVQSLGLLGDRLCVGAAGTFALYPLLNEAAPLALGTGLVAEELPASRGGLGEALGAVELSLSELLLLFATAGVYVDSAGRKSRSHELLWPAAPTGWGYTAPYLTVFSENALDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNPLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSDELRQQQRREMLKDPFVRSKFISPPTNFNHLVHVGPTEGRPNTRDGTRAQEQKSRGARSSGPQRPHSFSEAFRRPVSTGSDGLPGETDPLVKRKPWTSLSSESVSCPQGSLSPAASLIQVSERPRSLPPDPESESSP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
216PhosphorylationIRLADFGSCLRLNNN
EEECCCCCCEEECCC		15.24-
228PhosphorylationNNNGMVDSSVAVGTP
CCCCCCCCEEECCCC		18.46-
234PhosphorylationDSSVAVGTPDYISPE
CCEEECCCCCCCCHH		13.34-
470PhosphorylationTLRDSKASLSQTDGL
HHHHHCCCHHHCCCC		32.0822802335
472PhosphorylationRDSKASLSQTDGLHA
HHHCCCHHHCCCCCC		28.6522802335
481PhosphorylationTDGLHARSPAPNIQL
CCCCCCCCCCCCCHH		26.6328066266
597PhosphorylationPETNGIGSPEGQSQE
CCCCCCCCCCCCCHH		20.1823984901
602PhosphorylationIGSPEGQSQEAQLRK
CCCCCCCCHHHHHHH		40.6223984901
887PhosphorylationLRPRSFPSPTKCLRC
CCCCCCCCCCHHHHH		43.1024719451
943PhosphorylationALGVHPETGTGTAYE
HHCCCCCCCCCCCEE		44.48-
988PhosphorylationDAPDPRGSLASGVLL
CCCCCCCCCHHHHHH		23.2622817900
1229PhosphorylationQAPAPVQSLGLLGDR
CCCCCHHHCCCCCCC		25.3324719451
1414PhosphorylationRRFFFRVSDELRQQQ
CCHHHHCCHHHHHHH		22.5523984901
1457PhosphorylationPTEGRPNTRDGTRAQ
CCCCCCCCCCCCHHH		32.5926026062
1461PhosphorylationRPNTRDGTRAQEQKS
CCCCCCCCHHHHHHH		27.4126026062
1473PhosphorylationQKSRGARSSGPQRPH
HHHHCCCCCCCCCCC		38.8323984901
1474PhosphorylationKSRGARSSGPQRPHS
HHHCCCCCCCCCCCC		49.2723984901
1481PhosphorylationSGPQRPHSFSEAFRR
CCCCCCCCHHHHHCC		32.9026824392
1483PhosphorylationPQRPHSFSEAFRRPV
CCCCCCHHHHHCCCC		30.9126643407
1491PhosphorylationEAFRRPVSTGSDGLP
HHHCCCCCCCCCCCC		29.7217242355
1492PhosphorylationAFRRPVSTGSDGLPG
HHCCCCCCCCCCCCC		40.7217242355
1494PhosphorylationRRPVSTGSDGLPGET
CCCCCCCCCCCCCCC		28.7029472430
1511PhosphorylationLVKRKPWTSLSSESV
CCCCCCCCCCCCCCC		28.4621082442
1514PhosphorylationRKPWTSLSSESVSCP
CCCCCCCCCCCCCCC		31.6521183079
1515PhosphorylationKPWTSLSSESVSCPQ
CCCCCCCCCCCCCCC		38.9021183079
1524PhosphorylationSVSCPQGSLSPAASL
CCCCCCCCCCCCHHH		22.0428576409
1526PhosphorylationSCPQGSLSPAASLIQ
CCCCCCCCCCHHHEE		17.7522817900
1549PhosphorylationPPDPESESSP-----
CCCCCCCCCC-----		58.1323984901
1550PhosphorylationPDPESESSP------
CCCCCCCCC------		30.4927841257
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MRCKG_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MRCKG_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MRCKG_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MRCKG_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MRCKG_MOUSE

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Related Literatures of Post-Translational Modification

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