CO4A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO4A1_MOUSE
• UniProt AC: P02463
• Protein Name: Collagen alpha-1(IV) chain
• Gene Name: Col4a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1669
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane .
• Protein Description: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin..
• Protein Sequence: MGPRLSVWLLLLFAALLLHEERSRAAAKGDCGGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEGPHGPPGQKGDAGEPGLPGTKGTRGPPGAAGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFSGNPGPPGLPGMKGDPGEILGHVPGTLLKGERGFPGIPGMPGSPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGSSFQGPKGDKGEQGVSGPPGVPGQAQVKEKGDFAPTGEKGQKGEPGFPGVPGYGEKGEPGKQGPRGKPGKDGEKGERGSPGIPGDSGYPGLPGRQGPQGEKGEAGLPGPPGTVIGTMPLGEKGDRGYPGAPGLRGEPGPKGFPGTPGQPGPPGFPTPGQAGAPGFPGERGEKGDQGFPGVSLPGPSGRDGAPGPPGPPGPPGQPGHTNGIVECQPGPPGDQGPPGTPGQPGLTGEVGQKGQKGESCLACDTEGLRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGLEGLPGPQGSPGLIGQPGAKGEPGEIFFDMRLKGDKGDPGFPGQPGMPGRAGTPGRDGHPGLPGPKGSPGSIGLKGERGPPGGVGFPGSRGDIGPPGPPGVGPIGPVGEKGQAGFPGGPGSPGLPGPKGEAGKVVPLPGPPGAAGLPGSPGFPGPQGDRGFPGTPGRPGIPGEKGAVGQPGIGFPGLPGPKGVDGLPGEIGRPGSPGRPGFNGLPGNPGPQGQKGEPGIGLPGLKGQPGLPGIPGTPGEKGSIGGPGVPGEQGLTGPPGLQGIRGDPGPPGVQGPAGPPGVPGIGPPGAMGPPGGQGPPGSSGPPGIKGEKGFPGFPGLDMPGPKGDKGSQGLPGLTGQSGLPGLPGQQGTPGVPGFPGSKGEMGVMGTPGQPGSPGPAGTPGLPGEKGDHGLPGSSGPRGDPGFKGDKGDVGLPGMPGSMEHVDMGSMKGQKGDQGEKGQIGPTGDKGSRGDPGTPGVPGKDGQAGHPGQPGPKGDPGLSGTPGSPGLPGPKGSVGGMGLPGSPGEKGVPGIPGSQGVPGSPGEKGAKGEKGQSGLPGIGIPGRPGDKGDQGLAGFPGSPGEKGEKGSAGTPGMPGSPGPRGSPGNIGHPGSPGLPGEKGDKGLPGLDGVPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAGEKGEQGVPGRGFPGFPGSKGDKGSKGEVGFPGLAGSPGIPGVKGEQGFMGPPGPQGQPGLPGTPGHPVEGPKGDRGPQGQPGLPGHPGPMGPPGFPGINGPKGDKGNQGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGLPGVPGFQGQKGLPGLQGVKGDQGDQGVPGPKGLQGPPGPPGPYDVIKGEPGLPGPEGPPGLKGLQGPPGPKGQQGVTGSVGLPGPPGVPGFDGAPGQKGETGPFGPPGPRGFPGPPGPDGLPGSMGPPGTPSVDHGFLVTRHSQTTDDPLCPPGTKILYHGYSLLYVQGNERAHGQDLGTAGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPISGDNIRPFISRCAVCEAPAMVMAVHSQTIQIPQCPNGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
126	N-linked_Glycosylation	PPGIPGCNGTKGERG CCCCCCCCCCCCCCC	68.06	-
204	Hydroxylation	GPPGFTGPPGPPGPP CCCCCCCCCCCCCCC	27.84	-
207	Hydroxylation	GFTGPPGPPGPPGPP CCCCCCCCCCCCCCC	36.13	-
210	Hydroxylation	GPPGPPGPPGPPGEK CCCCCCCCCCCCCCC	36.13	-
587	Hydroxylation	GLKGERGPPGGVGFP CCCCCCCCCCCCCCC	30.50	-
602	Hydroxylation	GSRGDIGPPGPPGVG CCCCCCCCCCCCCCC	30.89	25645914
603	Hydroxylation	SRGDIGPPGPPGVGP CCCCCCCCCCCCCCC	63.81	25645914
605	Hydroxylation	GDIGPPGPPGVGPIG CCCCCCCCCCCCCCC	28.39	25645914
606	Hydroxylation	DIGPPGPPGVGPIGP CCCCCCCCCCCCCCC	56.89	25645914
623	Hydroxylation	EKGQAGFPGGPGSPG CCCCCCCCCCCCCCC	46.01	25645914
626	Hydroxylation	QAGFPGGPGSPGLPG CCCCCCCCCCCCCCC	46.10	25645914
629	Hydroxylation	FPGGPGSPGLPGPKG CCCCCCCCCCCCCCC	55.01	25645914
632	Hydroxylation	GPGSPGLPGPKGEAG CCCCCCCCCCCCCCC	64.06	25645914
647	Hydroxylation	KVVPLPGPPGAAGLP CEECCCCCCCCCCCC	23.39	-
656	Phosphorylation	GAAGLPGSPGFPGPQ CCCCCCCCCCCCCCC	21.65	26824392
979	Acetylation	GTPGVPGKDGQAGHP CCCCCCCCCCCCCCC	53.25	7630809
1086	Phosphorylation	GEKGEKGSAGTPGMP CCCCCCCCCCCCCCC	34.29	26239621
1089	Phosphorylation	GEKGSAGTPGMPGSP CCCCCCCCCCCCCCC	19.18	26239621
1095	Phosphorylation	GTPGMPGSPGPRGSP CCCCCCCCCCCCCCC	22.32	26239621
1110	Phosphorylation	GNIGHPGSPGLPGEK CCCCCCCCCCCCCCC	21.90	-
1214	Hydroxylation	GEQGFMGPPGPQGQP CCCCCCCCCCCCCCC	20.91	-
1303	Phosphorylation	GSPGITGSKGDMGLP CCCCCCCCCCCCCCC	25.47	28973931
1328	Acetylation	LPGLQGVKGDQGDQG CCCCCCCCCCCCCCC	64.69	7611573
1352	Phosphorylation	PPGPPGPYDVIKGEP CCCCCCCCCCCCCCC	28.85	-
1424	Hydroxylation	GPRGFPGPPGPDGLP CCCCCCCCCCCCCCC	30.80	-
1433	Phosphorylation	GPDGLPGSMGPPGTP CCCCCCCCCCCCCCC	20.73	26060331
1439	Phosphorylation	GSMGPPGTPSVDHGF CCCCCCCCCCCCCCE	20.40	26060331
1441	Phosphorylation	MGPPGTPSVDHGFLV CCCCCCCCCCCCEEE	39.76	26060331
1460	S-nitrosocysteine	QTTDDPLCPPGTKIL CCCCCCCCCCCCEEE	4.68	-
1460	S-nitrosylation	QTTDDPLCPPGTKIL CCCCCCCCCCCCEEE	4.68	21278135
1493	S-nitrosocysteine	DLGTAGSCLRKFSTM CCCCHHHHHHHHCCC	4.10	-
1493	Glutathionylation	DLGTAGSCLRKFSTM CCCCHHHHHHHHCCC	4.10	24333276
1493	S-nitrosylation	DLGTAGSCLRKFSTM CCCCHHHHHHHHCCC	4.10	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO4A1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO4A1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO4A1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CO4A1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.