HIP1_MOUSE - dbPTM
HIP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HIP1_MOUSE
UniProt AC Q8VD75
Protein Name Huntingtin-interacting protein 1 {ECO:0000250|UniProtKB:O00291}
Gene Name Hip1 {ECO:0000312|MGI:MGI:1099804}
Organism Mus musculus (Mouse).
Sequence Length 1029
Subcellular Localization Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR (By similarity)..
Protein Description Plays a role in clathrin-mediated endocytosis and trafficking. [PubMed: 11577110 Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner]
Protein Sequence MDRMASSMKQVSNPLPKVLSRRGVGAGMEAAERESFERTQTVSVNKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAMLCWKFCHVFHKLLRDGHPNVLKDSLRYKNELSDMSRMWGHLSEGYGQLCSIYLKLLRTRMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTTAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFQRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEVSSPDSEPVLEKDDLMDMDASQQTLFDNKFDDVFGSSLSSDPFNFNNQNGVNKDEKDHLIERLYREISGLTGQLDNMKIESQRAMLQLKGRVSELEAELAEQQHLGRQAMDDCEFLRTELDELKRQREDTEKAQRSLTEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSVARQAQVDLEREKKELADSFARTQEQQDVLENLKHELATSRQELQVLHSNLETSAQSEAKWLTQIAELEKEQGSLATVAAQREEELSALRDQLESTQIKLAGAQESMCQQVKDQRKTLLAGIRKAAEREIQEALSQLEEPTLISCAGSTDHLLSKVSSVSSCLEQLEKNGSQYLACPEDISELLHSITLLAHLTGDTIIQGSATSLRAPPEPADSLTEACRQYGRETLAYLSSLEEEGTMENADVTALRNCLSRVKTLGEELLPRGLDIKQEELGDLVDKEMAATSAAIEAATTRIEEILSKSRAGDTGVKLEVNERILGSCTSLMQAIKVLVVASKDLQKEIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATIMVDAADLVVQGKGKFEELMVCSREIAASTAQLVAASKVKANKGSLNLTQLQQASRGVNQATAAVVASTISGKSQIEETDSMDFSSMTLTQIKRQEMDSQVRVLELENDLQKERQKLGELRKKHYELAGVAEGWEEGTEASPSTVQEAIPDKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MDRMASSMKQVSN
--CHHHHHHHHHHCC		22.9424719451
9UbiquitinationDRMASSMKQVSNPLP
HHHHHHHHHHCCCHH		49.8827667366
12PhosphorylationASSMKQVSNPLPKVL
HHHHHHHCCCHHHHH		30.1824719451
46UbiquitinationTQTVSVNKAINTQEV
CCEEEHHHCCCCCCH		48.7922790023
78UbiquitinationKGAQTFWSVVNRLPL
HCHHHHHHHHHCCCC		16.4027667366
84UbiquitinationWSVVNRLPLSSNAML
HHHHHCCCCCCCHHH		27.2727667366
87UbiquitinationVNRLPLSSNAMLCWK
HHCCCCCCCHHHHHH		35.9727667366
93UbiquitinationSSNAMLCWKFCHVFH
CCCHHHHHHHHHHHH		7.8727667366
112UbiquitinationDGHPNVLKDSLRYKN
CCCCCHHHHHHHHHH		40.7727667366
114PhosphorylationHPNVLKDSLRYKNEL
CCCHHHHHHHHHHHH		17.1022817900
118UbiquitinationLKDSLRYKNELSDMS
HHHHHHHHHHHHHHH		37.2022790023
121UbiquitinationSLRYKNELSDMSRMW
HHHHHHHHHHHHHHH		8.0127667366
130UbiquitinationDMSRMWGHLSEGYGQ
HHHHHHHHHHCHHHH		15.6327667366
154PhosphorylationRTRMEYHTKNPRFPG
HHHHHHHCCCCCCCC		31.4519144319
155UbiquitinationTRMEYHTKNPRFPGN
HHHHHHCCCCCCCCC		52.2022790023
283UbiquitinationSSNLQYFKRLIQIPQ
HHCHHHHHHHHCCCC		41.1622790023
319PhosphorylationVVIPAEVSSPDSEPV
EEEECCCCCCCCCCC		27.8829472430
320PhosphorylationVIPAEVSSPDSEPVL
EEECCCCCCCCCCCC		37.5926824392
323PhosphorylationAEVSSPDSEPVLEKD
CCCCCCCCCCCCCCC		47.3827180971
338PhosphorylationDLMDMDASQQTLFDN
CCCCCCHHHHHHHCC		20.68-
372UbiquitinationQNGVNKDEKDHLIER
CCCCCHHHHHHHHHH		63.0927667366
381UbiquitinationDHLIERLYREISGLT
HHHHHHHHHHHHCCC		16.6627667366
395UbiquitinationTGQLDNMKIESQRAM
CCCHHHCHHHHHHHH		49.9622790023
406UbiquitinationQRAMLQLKGRVSELE
HHHHHHHHHHHHHHH		31.5422790023
410PhosphorylationLQLKGRVSELEAELA
HHHHHHHHHHHHHHH		34.7926060331
571PhosphorylationELEKEQGSLATVAAQ
HHHHHHCCHHHHHHH		17.9628066266
655PhosphorylationHLLSKVSSVSSCLEQ
HHHHHHHHHHHHHHH		29.0729514104
798PhosphorylationTRIEEILSKSRAGDT
HHHHHHHHHCCCCCC		33.9623737553
950PhosphorylationASTISGKSQIEETDS
HHHHCCCCCCEECCC		39.6620469934
955PhosphorylationGKSQIEETDSMDFSS
CCCCCEECCCCCCCC		22.1520469934
957PhosphorylationSQIEETDSMDFSSMT
CCCEECCCCCCCCCC		27.8920469934
961PhosphorylationETDSMDFSSMTLTQI
ECCCCCCCCCCHHHH		18.2220469934
962PhosphorylationTDSMDFSSMTLTQIK
CCCCCCCCCCHHHHH		18.7720469934
964PhosphorylationSMDFSSMTLTQIKRQ
CCCCCCCCHHHHHHH		28.7120469934
966PhosphorylationDFSSMTLTQIKRQEM
CCCCCCHHHHHHHHH		21.0520469934
1014PhosphorylationAEGWEEGTEASPSTV
HCCCCCCCCCCCCHH		31.4925338131
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HIP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HIP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HIP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HIP1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HIP1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-154, AND MASSSPECTROMETRY.

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