CHD7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHD7_MOUSE
• UniProt AC: A2AJK6
• Protein Name: Chromodomain-helicase-DNA-binding protein 7
• Gene Name: Chd7
• Organism: Mus musculus (Mouse).
• Sequence Length: 2986
• Subcellular Localization: Nucleus .
• Protein Description: Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity)..
• Protein Sequence: MADPGMMSLFGEDGSLFSEGLEGLGECGYPENPVNPMGQQMPIDQGFPSLQPSLHHPSPNQNQTKLTHFDHYSQYEQKMHLMDQPNRMMGSAPGNGLASPHSQYHTPPVPQVPHGGGGGGQMGVYPGIQNERHGQSFVDGGSMWGPRAVQVPDQIRAPYQQQQPQPAPSGPPAQGHPQHMQQMGSYLARGDFSMQQHGQPQQRMGQFSQGQEGLSQGSPFIATSGPGHLSHMPQQSPSMAPSLRHPVQQQFHHHPAALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRNQTVPSPTVNNSGQYSRYPYSNLNQGLVNSTGMNQNLGLTNSTPMNQSVPRYPNAVGFPSNSGQGLVHQQPIHSSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGMPMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQPRSFMGMSSAPRELTGHMRPNGCPGVGLADPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHQSSPPHPHHQPWAQLHPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSAQNAQLVKSDDYLPSIEQQPQQKKKKKKNNHIAAGDSSKGFGKDDFPGGVENQELRRNSLDVSQEEKKKKKRPKVKKDPKESKEPKEKKEPKTPKAPKIPKEPKEKKAKTVTPKPKSSKKSSNKKPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPAPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRDSPSNTSQSEQQESVDAEGPVVEKIMSSRLVKKQKESGEEVEVEEFYVKYKNFSYLHCQWASVEDLEKDKRIQQKIKRFKSKQGQSKFLSEIEDDLFNPDYVEVDRIMDFARSTDDRGEPVIHYLVKWCSLPYEDSTWELKQDIDQTKIEEFEKLMSREPETERVERPPADDWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLINGAEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRKQTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGRWTDILSHGRYKRQLTEQDVETICRAILVYCLNHYRGDENIKSFIWDLITPTADGQTRALLNHSGLSAPVPRGRKGKKVKAQSTQPVVHDAHWLASCNPDALFQEDSYKKHLKHHCNKVLLRVRMLYYLRQEVIGDQAEKILEGADSSEADVWIPEPFHAEVPTDWWDREADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYKPTRAPFKDEIDEFANSPAEDKEESMEVHSSGKHSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRALEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDESLGKYFSCFVAMCRRVCRMPAKPEDEPPDLASLIEPITEERASRTLYRIELLRKIREQVLHHPQLSDRLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKSFAQNRGASTVPPLNTLAMGFGQTPPVISSAHVHEEKAMEQAEGKAEECEHSPAKERSDGKEEEEEAGGAKDGKQECEVEASSVKGELKGVEGSADPGSKSVSEKGSEEDEEEKLEDDDKSEESSQPEAGAVSRGKTFDEESNASLSTARDETRDGFYMEDGDASVAQLLHERTFAFSFWPKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLVPGYPPSAVDSPLQKRSFAELSMVSQASISASEDITTSPQLSKDDALNLSVPRQRRRRRRKVEIEAERAAKRRNLMEMVAQLRESQVVSENGQEKVVDLSKASREATSSTSNFSSLTSKFILPNVSTPVSDAFKSQMELLQAGLSRTPTRHMLNGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTPLSAEDAEVTKAFEEDIETPPIRNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVDWLKLHPTYTVDMPSYVPKNTDVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAAAAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAKSPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDGTSKAEEKGNDNEDENRDSEKSTDTVSAADSANGSVGAATAPAALPSNPLAFNPFLLSTMAPGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGTSEEKAADKAEGGPCKDGETLEGSDAEENLDKTVESSILEDEVAQGEELDSLEGGDEIENTGNDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
147	Methylation	GGSMWGPRAVQVPDQ CCCCCCCCCCCCCHH	43.37	-
262	Phosphorylation	PAALHGESVAHSPRF CHHHCCCCCCCCCCC	29.24	25293948
266	Phosphorylation	HGESVAHSPRFSPNP CCCCCCCCCCCCCCC	14.18	25293948
280	Asymmetric dimethylarginine	PPQQGAVRPQTLNFS CCCCCCCCCCCCCCC	19.64	-
280	Methylation	PPQQGAVRPQTLNFS CCCCCCCCCCCCCCC	19.64	24129315
292	Phosphorylation	NFSSRNQTVPSPTVN CCCCCCCCCCCCCCC	37.62	-
295	Phosphorylation	SRNQTVPSPTVNNSG CCCCCCCCCCCCCCC	28.94	23527152
301	Phosphorylation	PSPTVNNSGQYSRYP CCCCCCCCCCCCCCC	23.28	-
307	Phosphorylation	NSGQYSRYPYSNLNQ CCCCCCCCCCCCCCC	10.69	22802335
309	Phosphorylation	GQYSRYPYSNLNQGL CCCCCCCCCCCCCCC	10.97	22802335
310	Phosphorylation	QYSRYPYSNLNQGLV CCCCCCCCCCCCCCC	30.27	22802335
319	Phosphorylation	LNQGLVNSTGMNQNL CCCCCCCCCCCCCCC	20.89	22802335
331	Phosphorylation	QNLGLTNSTPMNQSV CCCCCCCCCCCCCCC	28.75	22802335
332	Phosphorylation	NLGLTNSTPMNQSVP CCCCCCCCCCCCCCC	28.73	22802335
337	Phosphorylation	NSTPMNQSVPRYPNA CCCCCCCCCCCCCCC	29.14	22802335
459	Phosphorylation	PRSFMGMSSAPRELT CCCCCCCCCCCHHHC	20.02	27149854
550	Phosphorylation	KVPVHQHSPSEPFLE CCCCCCCCCCCCCCC	24.45	25159016
552	Phosphorylation	PVHQHSPSEPFLEKP CCCCCCCCCCCCCCC	62.00	25266776
604	Phosphorylation	NHIAAGDSSKGFGKD CCCCCCCCCCCCCCC	32.79	22802335
626	Phosphorylation	NQELRRNSLDVSQEE CHHHHHCCCCCCHHH	24.92	28833060
630	Phosphorylation	RRNSLDVSQEEKKKK HHCCCCCCHHHHHHH	31.38	26643407
676	Acetylation	EPKEKKAKTVTPKPK CCCCCCCCCCCCCCC	53.02	23864654
679	Phosphorylation	EKKAKTVTPKPKSSK CCCCCCCCCCCCCCC	30.72	24719451
681	Acetylation	KAKTVTPKPKSSKKS CCCCCCCCCCCCCCC	56.57	23864654
709	Phosphorylation	KKVNKGKTEGSENSD HHHHCCCCCCCCCCC	55.00	24759943
712	Phosphorylation	NKGKTEGSENSDLDK HCCCCCCCCCCCCCC	27.63	23608596
715	Phosphorylation	KTEGSENSDLDKTPP CCCCCCCCCCCCCCC	35.18	23608596
720	Phosphorylation	ENSDLDKTPPPSPAP CCCCCCCCCCCCCCC	40.47	23608596
724	Phosphorylation	LDKTPPPSPAPEEDE CCCCCCCCCCCCCCC	39.19	23608596
758	Phosphorylation	EDLEFKISDEEADDA CCCCEECCHHHCCCC	39.29	27841257
797	Phosphorylation	PVVEKIMSSRLVKKQ HHHHHHHHHCCHHHH	18.77	-
798	Phosphorylation	VVEKIMSSRLVKKQK HHHHHHHHCCHHHHH	16.56	-
990	Phosphorylation	DEMGLGKTIQSITFL HCCCCCHHHHHHHHH	23.58	-
1045	Phosphorylation	GSQASRRTIQLYEMY CCHHHHHHEEEEEEE	16.38	28576409
1049	Phosphorylation	SRRTIQLYEMYFKDP HHHHEEEEEEECCCC	5.14	28576409
1052	Phosphorylation	TIQLYEMYFKDPQGR HEEEEEEECCCCCCC	8.78	28576409
1101	Acetylation	IDEAHRLKNRNCKLL ECHHHHHHCCCCCHH	54.54	15624415
1106	Acetylation	RLKNRNCKLLEGLKM HHHCCCCCHHCCCCC	60.71	15624423
1492	Phosphorylation	THTITIESEGKGSTF CCEEEEEECCCCCEE	48.04	20531401
1545	Phosphorylation	RNNLVIDTPRVRKQT CCCEEECCHHHHHHH	11.23	22006019
1567	Phosphorylation	EDELMEFSDLESDSE HHHHCHHHCCCCCCC	28.16	21149613
1571	Phosphorylation	MEFSDLESDSEEKPC CHHHCCCCCCCCCCC	54.45	21149613
1573	Phosphorylation	FSDLESDSEEKPCAK HHCCCCCCCCCCCCC	57.86	21149613
1684	Ubiquitination	APVPRGRKGKKVKAQ CCCCCCCCCCCCCCC	77.30	-
1686	Ubiquitination	VPRGRKGKKVKAQST CCCCCCCCCCCCCCC	58.38	-
1687	Ubiquitination	PRGRKGKKVKAQSTQ CCCCCCCCCCCCCCC	58.60	-
1847	Phosphorylation	REDEDPEYKPTRAPF CCCCCCCCCCCCCCC	27.88	27841257
1850	Phosphorylation	EDPEYKPTRAPFKDE CCCCCCCCCCCCHHH	35.00	27841257
1864	Phosphorylation	EIDEFANSPAEDKEE HHHHHCCCCCCCHHH	23.27	25521595
1872	Phosphorylation	PAEDKEESMEVHSSG CCCCHHHHCCCCCCC	22.72	21149613
1877	Phosphorylation	EESMEVHSSGKHSES HHHCCCCCCCCCCCC	46.06	21149613
1878	Phosphorylation	ESMEVHSSGKHSESN HHCCCCCCCCCCCCC	36.66	21149613
1995	Acetylation	RAFARLDKKSDESLG HHHHCCCCCCCHHHH	59.79	19861437
2100	Phosphorylation	GAAKHGVSRTDYHIL HHHHHCCCCCCHHCC	33.77	22817900
2128	Phosphorylation	FAQNRGASTVPPLNT HHHHCCCCCCCCCCH	32.53	26239621
2129	Phosphorylation	AQNRGASTVPPLNTL HHHCCCCCCCCCCHH	36.18	26239621
2135	Phosphorylation	STVPPLNTLAMGFGQ CCCCCCCHHCCCCCC	24.47	22802335
2143	Phosphorylation	LAMGFGQTPPVISSA HCCCCCCCCCCCCCH	29.91	22802335
2148	Phosphorylation	GQTPPVISSAHVHEE CCCCCCCCCHHHCHH	23.00	26239621
2149	Phosphorylation	QTPPVISSAHVHEEK CCCCCCCCHHHCHHH	15.98	26239621
2171	Phosphorylation	KAEECEHSPAKERSD HHHHCCCCCCCCCCC	12.31	25159016
2202	Phosphorylation	ECEVEASSVKGELKG EEEEEEEECCCEECC	34.59	27841257
2218	Phosphorylation	EGSADPGSKSVSEKG CCCCCCCCCCCCCCC	27.44	25159016
2220	Phosphorylation	SADPGSKSVSEKGSE CCCCCCCCCCCCCCH	32.35	23375375
2222	Phosphorylation	DPGSKSVSEKGSEED CCCCCCCCCCCCHHH	40.45	23375375
2224	Acetylation	GSKSVSEKGSEEDEE CCCCCCCCCCHHHHH	61.30	15628715
2226	Phosphorylation	KSVSEKGSEEDEEEK CCCCCCCCHHHHHHH	49.21	26745281
2240	Phosphorylation	KLEDDDKSEESSQPE HCCCCCCCCCCCCCC	54.30	27841257
2243	Phosphorylation	DDDKSEESSQPEAGA CCCCCCCCCCCCCCC	30.16	27841257
2261	Phosphorylation	GKTFDEESNASLSTA CCCCCHHHCCCCCCC	35.33	21149613
2264	Phosphorylation	FDEESNASLSTARDE CCHHHCCCCCCCCHH	27.40	21149613
2266	Phosphorylation	EESNASLSTARDETR HHHCCCCCCCCHHHC	19.95	28066266
2267	Phosphorylation	ESNASLSTARDETRD HHCCCCCCCCHHHCC	30.88	28066266
2272	Phosphorylation	LSTARDETRDGFYME CCCCCHHHCCCEECC	38.05	26370283
2284	Phosphorylation	YMEDGDASVAQLLHE ECCCCCCHHHHHHHH	23.79	25266776
2345	Phosphorylation	YPPSAVDSPLQKRSF CCHHHCCCHHHHCCH	22.40	25266776
2351	Phosphorylation	DSPLQKRSFAELSMV CCHHHHCCHHHHHHC	35.52	29895711
2356	Phosphorylation	KRSFAELSMVSQASI HCCHHHHHHCCHHHC	14.51	29895711
2364	Phosphorylation	MVSQASISASEDITT HCCHHHCCCCCCCCC	24.21	29895711
2376	Phosphorylation	ITTSPQLSKDDALNL CCCCCCCCHHHHCCC	28.88	29895711
2384	Phosphorylation	KDDALNLSVPRQRRR HHHHCCCCCCHHHHH	29.06	28066266
2460	Phosphorylation	KFILPNVSTPVSDAF CCCCCCCCCCCHHHH	33.36	28066266
2461	Phosphorylation	FILPNVSTPVSDAFK CCCCCCCCCCHHHHH	24.35	28066266
2464	Phosphorylation	PNVSTPVSDAFKSQM CCCCCCCHHHHHHHH	25.15	28066266
2479	Phosphorylation	ELLQAGLSRTPTRHM HHHHHHHCCCCCCHH	32.94	19854140
2481	Phosphorylation	LQAGLSRTPTRHMLN HHHHHCCCCCCHHHC	26.15	19854140
2483	Phosphorylation	AGLSRTPTRHMLNGS HHHCCCCCCHHHCCC	32.37	23737553
2524	Phosphorylation	SHKRTPLSAEDAEVT CCCCCCCCHHHHHHH	30.71	-
2531	Phosphorylation	SAEDAEVTKAFEEDI CHHHHHHHHHHHHCC	14.25	22324799
2540	Phosphorylation	AFEEDIETPPIRNIP HHHHCCCCCCCCCCC	34.40	22817900
2548	Phosphorylation	PPIRNIPSPGQLDPD CCCCCCCCCCCCCCC	37.55	23527152
2556	Phosphorylation	PGQLDPDTRIPVINL CCCCCCCCCCEEEEC	35.57	23984901
2567	Phosphorylation	VINLEDGTRLVGEDA EEECCCCCEECCCCC	32.90	23984901
2608	Phosphorylation	NTDVLFSSFQKPKQK CCCCCCCCCCCHHHH	25.10	-
2941	Phosphorylation	GPCKDGETLEGSDAE CCCCCCCCCCCCCHH	35.32	25521595
2945	Phosphorylation	DGETLEGSDAEENLD CCCCCCCCCHHHHHH	25.03	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHD7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHD7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHD7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CHD7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.