SF3B3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SF3B3_MOUSE
• UniProt AC: Q921M3
• Protein Name: Splicing factor 3B subunit 3
• Gene Name: Sf3b3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1217
• Subcellular Localization: Nucleus .
• Protein Description: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron..
• Protein Sequence: MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLILSPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVLIGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDFFQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRTPPEVSKKLEDIRTRYAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Ubiquitination	IHQETFGKSGCRRIV HHHHHHCCCCCCEEC	39.21	-
155	Phosphorylation	AAARLTISSPLEAHK HHHHCCCCCCHHHHH	22.22	24719451
156	Phosphorylation	AARLTISSPLEAHKA HHHCCCCCCHHHHHC	29.65	28066266
224	Phosphorylation	LNHVVRKYSEPLEEH CHHHHHHCCCCHHHH	14.01	-
328	Acetylation	MVTEIRLKYFDTVPV CEEEHHHHHCCHHHH	33.74	22826441
393	Ubiquitination	FFQPRPLKNLVLVDE EECCCCCCCEEEEEC	51.42	-
541	Acetylation	NEWKTPGKKTIVKCA CCCCCCCCCEEEEEE	48.20	7718435
571	Phosphorylation	VYFEMDPSGQLNEYT EEEEECCCCCCCHHH	34.60	22802335
577	Phosphorylation	PSGQLNEYTERKEMS CCCCCCHHHHCCCCC	16.90	22802335
578	Phosphorylation	SGQLNEYTERKEMSA CCCCCHHHHCCCCCC	24.12	22802335
584	Phosphorylation	YTERKEMSADVVCMS HHHCCCCCCCEEEEE	23.55	22802335
725	Phosphorylation	RSWLSYSYQSRFHLT CCHHHCCCCCCCEEC	11.41	22802335
727	Phosphorylation	WLSYSYQSRFHLTPL HHHCCCCCCCEECCC	28.78	22802335
769	Ubiquitination	LRILALEKLGAVFNQ HHHHHHHHHHHHHHH	53.74	-
916	Phosphorylation	VAKDLILSPRSVAGG EEECEECCCCCCCCE	15.98	24719451
965	Ubiquitination	RVLIGVGKLLRVYDL EEEEECHHHHHHEEC	41.77	-
965	Acetylation	RVLIGVGKLLRVYDL EEEEECHHHHHHEEC	41.77	22826441
1049	Ubiquitination	DTVAGADKFGNICVV CCCCCCCCCCCEEEE	55.42	-
1074	Ubiquitination	DEDPTGNKALWDRGL CCCCCCCHHHHHHCC	46.32	-
1162	Phosphorylation	LCGRDHLSFRSYYFP CCCCCCCCCHHEEEE	18.39	27149854
1194	Phosphorylation	PNKQKNVSEELDRTP CCCCCCCCHHHHCCC	34.44	26643407
1200	Phosphorylation	VSEELDRTPPEVSKK CCHHHHCCCHHHHHH	42.75	20139300
1205	Phosphorylation	DRTPPEVSKKLEDIR HCCCHHHHHHHHHHH	23.55	20139300
1206	Acetylation	RTPPEVSKKLEDIRT CCCHHHHHHHHHHHH	67.56	156521

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SF3B3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SF3B3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SF3B3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SF3B3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.