TXNL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXNL1_MOUSE
• UniProt AC: Q8CDN6
• Protein Name: Thioredoxin-like protein 1
• Gene Name: Txnl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 289
• Subcellular Localization: Cytoplasm. Nucleus. At least 85% of the cellular TXNL1 is proteasome-associated..
• Protein Description: Active thioredoxin with a redox potential of about -250 mV..
• Protein Sequence: MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDADIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDMSFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTLFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MVGVKPVGSDPD ---CCCCCCCCCCCC	28.23	-
9	Phosphorylation	VGVKPVGSDPDFQPE CCCCCCCCCCCCCHH	46.32	27180971
18	Phosphorylation	PDFQPELSGAGSRLA CCCCHHHCCCCCCEE	25.57	28464351
28	Ubiquitination	GSRLAVVKFTMRGCG CCCEEEEEEECCCCC	28.63	-
37	Glutathionylation	TMRGCGPCLRIAPAF ECCCCCHHHHHHHHH	2.12	24333276
45	Phosphorylation	LRIAPAFSSMSNKYP HHHHHHHHHHCCCCC	27.51	29472430
46	Phosphorylation	RIAPAFSSMSNKYPQ HHHHHHHHHCCCCCC	21.56	29472430
48	Phosphorylation	APAFSSMSNKYPQAV HHHHHHHCCCCCCEE	31.92	29472430
85	Ubiquitination	TFLFFRNKVRIDQYQ EEEEECCCCCCEECC	28.74	-
102	Ubiquitination	DAVGLEEKIKQHLEN CCCCHHHHHHHHHHC	45.92	27667366
104	Ubiquitination	VGLEEKIKQHLENDP CCHHHHHHHHHHCCC	42.61	27667366
104	Acetylation	VGLEEKIKQHLENDP CCHHHHHHHHHHCCC	42.61	22826441
113	Phosphorylation	HLENDPGSNEDADIP HHHCCCCCCCCCCCC	42.29	25521595
121	Ubiquitination	NEDADIPKGYMDLMP CCCCCCCCCHHHHHH	64.11	-
149	S-nitrosylation	DEHGFDNCLRKDMSF CCCCHHHHHHHCHHH	4.13	20925432
149	S-nitrosocysteine	DEHGFDNCLRKDMSF CCCCHHHHHHHCHHH	4.13	-
181	Ubiquitination	PVKLYSMKFQGPDNG CEEEEEEEEECCCCC	28.70	-
192	Ubiquitination	PDNGQGPKYVKIFIN CCCCCCCCEEEEEEE	70.29	27667366
192	Acetylation	PDNGQGPKYVKIFIN CCCCCCCCEEEEEEE	70.29	22826441
226	Ubiquitination	ELTEDDIKEDGIVPL ECCHHHHCCCCEEEE	57.66	-
279	Ubiquitination	ATNMNDFKRVVGKKG CCCHHHHHHHHCCCC	47.34	-
279	Acetylation	ATNMNDFKRVVGKKG CCCHHHHHHHHCCCC	47.34	68343

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXNL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXNL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXNL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TXNL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, AND MASSSPECTROMETRY.
PubMed: 19367708