PSMD6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMD6_MOUSE
• UniProt AC: Q99JI4
• Protein Name: 26S proteasome non-ATPase regulatory subunit 6
• Gene Name: Psmd6
• Organism: Mus musculus (Mouse).
• Sequence Length: 389
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
• Protein Sequence: MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVREELMAAVRENNMAPYYEALCKSLDWQMDVDLLSKMKKANEEELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCQIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAIVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVDFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	LEEEGLPKNPDLRIA HHHCCCCCCCCCHHH	82.95	22790023
98	Phosphorylation	AEKNLGESEIRDAMM HHHHCCHHHHHHHHH	36.20	29514104
112	Glutathionylation	MAKAEYLCQIGDKEG HHHHHHHHHCCCCCC	2.44	24333276
117	Acetylation	YLCQIGDKEGALTAF HHHHCCCCCCCCHHH	53.48	22826441
130	Acetylation	AFRKTYDKTVALGHR HHHHHCCHHHHHHHH	34.19	22826441
166	Phosphorylation	RNTEKAKSLIEEGGD CCHHHHHHHHHCCCC	39.16	24719451
284	Acetylation	IVEQEMKKDWLFAPH HHHHHHCCCCCCCCH	53.48	22826441
361	Phosphorylation	VETNRPDSKNWQYQE HHHCCCCCCCCCHHH	30.48	25338131
362	Ubiquitination	ETNRPDSKNWQYQET HHCCCCCCCCCHHHH	70.37	22790023
371	Ubiquitination	WQYQETIKKGDLLLN CCHHHHHHHCHHHHH	59.11	22790023
372	Malonylation	QYQETIKKGDLLLNR CHHHHHHHCHHHHHH	54.53	32601280
384	Phosphorylation	LNRVQKLSRVINM-- HHHHHHHHHHHCC--	31.38	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSMD6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMD6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMD6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS4_HUMAN	PSMC1	physical	26496610
PRS7_HUMAN	PSMC2	physical	26496610
PRS6A_HUMAN	PSMC3	physical	26496610
PRS6B_HUMAN	PSMC4	physical	26496610
PRS8_HUMAN	PSMC5	physical	26496610
PRS10_HUMAN	PSMC6	physical	26496610
PSMD1_HUMAN	PSMD1	physical	26496610
PSMD2_HUMAN	PSMD2	physical	26496610
PSMD3_HUMAN	PSMD3	physical	26496610
PSMD4_HUMAN	PSMD4	physical	26496610
PSMD5_HUMAN	PSMD5	physical	26496610
PSMD7_HUMAN	PSMD7	physical	26496610
PSMD8_HUMAN	PSMD8	physical	26496610
PSD10_HUMAN	PSMD10	physical	26496610
PSD11_HUMAN	PSMD11	physical	26496610
PSD12_HUMAN	PSMD12	physical	26496610
PSD13_HUMAN	PSMD13	physical	26496610
UBE3A_HUMAN	UBE3A	physical	26496610
NCOA4_HUMAN	NCOA4	physical	26496610
UBP14_HUMAN	USP14	physical	26496610
TXNL1_HUMAN	TXNL1	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
PSDE_HUMAN	PSMD14	physical	26496610
PRDX3_HUMAN	PRDX3	physical	26496610
ADRM1_HUMAN	ADRM1	physical	26496610
NU188_HUMAN	NUP188	physical	26496610
PITC1_HUMAN	PITPNC1	physical	26496610
UCHL5_HUMAN	UCHL5	physical	26496610
RSF1_HUMAN	RSF1	physical	26496610
MI4GD_HUMAN	MIF4GD	physical	26496610
PAAF1_HUMAN	PAAF1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.