NCOA4_HUMAN - dbPTM
NCOA4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NCOA4_HUMAN
UniProt AC Q13772
Protein Name Nuclear receptor coactivator 4
Gene Name NCOA4
Organism Homo sapiens (Human).
Sequence Length 614
Subcellular Localization
Protein Description Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma..
Protein Sequence MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTSSRACNFFNNVGGNLKGLENWLLKSEKSSYQKCNSHSTTSSFSIEMEKVGDQELPDQDEMDLSDWLVTPQESHKLRKPENGSRETSEKFKLLFQSYNVNDWLVKTDSCTNCQGNQPKGVEIENLGNLKCLNDHLEAKKPLSTPSMVTEDWLVQNHQDPCKVEEVCRANEPCTSFAECVCDENCEKEALYKWLLKKEGKDKNGMPVEPKPEPEKHKDSLNMWLCPRKEVIEQTKAPKAMTPSRIADSFQVIKNSPLSEWLIRPPYKEGSPKEVPGTEDRAGKQKFKSPMNTSWCSFNTADWVLPGKKMGNLSQLSSGEDKWLLRKKAQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLKVDKEKWLYRTPLQM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42UbiquitinationLRAEQQIKDNLREVK
HHHHHHHHHHHHHHH		35.9021906983
42 (in isoform 2)Ubiquitination-35.9021906983
42 (in isoform 1)Ubiquitination-35.9021890473
49UbiquitinationKDNLREVKAQIHSCI
HHHHHHHHHHHHHHH		29.80-
57PhosphorylationAQIHSCISRHLECLR
HHHHHHHHHHHHHHH		20.27-
127PhosphorylationVCLERLGSLTLKPED
HHHHHHCCCEECCCC		23.8324719451
156PhosphorylationQTITTFGSLKTIQIP
HHHHHCCCCCEEECC		23.6222617229
171PhosphorylationEHLMAHASSANIGPF
HHHHHHHHHCCCHHH		21.8122617229
172PhosphorylationHLMAHASSANIGPFL
HHHHHHHHCCCHHHH		26.5622617229
181 (in isoform 2)Ubiquitination-57.1221906983
181UbiquitinationNIGPFLEKRGCISMP
CCHHHHHHCCCCCCC		57.1221906983
181 (in isoform 1)Ubiquitination-57.1221890473
186PhosphorylationLEKRGCISMPEQKSA
HHHCCCCCCCCCCCC		32.1525627689
192PhosphorylationISMPEQKSASGIVAV
CCCCCCCCCCCCEEE		27.6222199227
194PhosphorylationMPEQKSASGIVAVPF
CCCCCCCCCCEEEEH		35.8222199227
202PhosphorylationGIVAVPFSEWLLGSK
CCEEEEHHHHHHCCC		23.0724719451
209UbiquitinationSEWLLGSKPASGYQA
HHHHHCCCCCCCCCC		42.69-
210PhosphorylationEWLLGSKPASGYQAP
HHHHCCCCCCCCCCC		33.1027251275
212PhosphorylationLLGSKPASGYQAPYI
HHCCCCCCCCCCCCC		46.70-
231UbiquitinationPQDWLTQKQTLENSQ
HHHHHHHHHHHCCCC		39.76-
233PhosphorylationDWLTQKQTLENSQTS
HHHHHHHHHCCCCHH		42.9729514088
237PhosphorylationQKQTLENSQTSSRAC
HHHHHCCCCHHHHHH		26.0125159151
239PhosphorylationQTLENSQTSSRACNF
HHHCCCCHHHHHHHH		28.6129514088
240PhosphorylationTLENSQTSSRACNFF
HHCCCCHHHHHHHHH		15.3629514088
241PhosphorylationLENSQTSSRACNFFN
HCCCCHHHHHHHHHH		27.5629514088
253PhosphorylationFFNNVGGNLKGLENW
HHHHCCCCCHHHHHH		32.4327251275
255UbiquitinationNNVGGNLKGLENWLL
HHCCCCCHHHHHHHH		66.50-
263UbiquitinationGLENWLLKSEKSSYQ
HHHHHHHHCCCCCCH		55.1621906983
263 (in isoform 1)Ubiquitination-55.1621890473
266UbiquitinationNWLLKSEKSSYQKCN
HHHHHCCCCCCHHCC		52.36-
267PhosphorylationWLLKSEKSSYQKCNS
HHHHCCCCCCHHCCC		30.1726434552
268PhosphorylationLLKSEKSSYQKCNSH
HHHCCCCCCHHCCCC		42.5226434552
271UbiquitinationSEKSSYQKCNSHSTT
CCCCCCHHCCCCCCC		27.44-
277O-linked_GlycosylationQKCNSHSTTSSFSIE
HHCCCCCCCCCEEEE		25.8530379171
279PhosphorylationCNSHSTTSSFSIEME
CCCCCCCCCEEEEEE		29.4928348404
280PhosphorylationNSHSTTSSFSIEMEK
CCCCCCCCEEEEEEE		22.4128348404
282PhosphorylationHSTTSSFSIEMEKVG
CCCCCCEEEEEEECC		21.4228348404
287UbiquitinationSFSIEMEKVGDQELP
CEEEEEEECCCCCCC		50.65-
295PhosphorylationVGDQELPDQDEMDLS
CCCCCCCCCCCCCHH		79.6927251275
302PhosphorylationDQDEMDLSDWLVTPQ
CCCCCCHHHHCCCHH		23.6029514088
307PhosphorylationDLSDWLVTPQESHKL
CHHHHCCCHHHHCCC		19.6525159151
313UbiquitinationVTPQESHKLRKPENG
CCHHHHCCCCCCCCC		60.3021906983
313 (in isoform 1)Ubiquitination-60.3021890473
316UbiquitinationQESHKLRKPENGSRE
HHHCCCCCCCCCCCC		68.09-
329UbiquitinationRETSEKFKLLFQSYN
CCCHHHHHHHHHHCC		56.18-
334PhosphorylationKFKLLFQSYNVNDWL
HHHHHHHHCCCCCEE		16.0227422710
350PhosphorylationKTDSCTNCQGNQPKG
EECCCCCCCCCCCCC		2.7127251275
356UbiquitinationNCQGNQPKGVEIENL
CCCCCCCCCEEEEEC		66.86-
367UbiquitinationIENLGNLKCLNDHLE
EEECCCCEEHHHHHH		40.45-
377UbiquitinationNDHLEAKKPLSTPSM
HHHHHCCCCCCCCCC		59.23-
411PhosphorylationCRANEPCTSFAECVC
HHCCCCCCCHHHHCC		37.2828348404
412PhosphorylationRANEPCTSFAECVCD
HCCCCCCCHHHHCCC		29.2227050516
424UbiquitinationVCDENCEKEALYKWL
CCCCCCCHHHHHHHH		50.95-
428PhosphorylationNCEKEALYKWLLKKE
CCCHHHHHHHHHHHC		13.7327251275
429 (in isoform 1)Ubiquitination-32.0121890473
429UbiquitinationCEKEALYKWLLKKEG
CCHHHHHHHHHHHCC		32.0121890473
429UbiquitinationCEKEALYKWLLKKEG
CCHHHHHHHHHHHCC		32.0121890473
439UbiquitinationLKKEGKDKNGMPVEP
HHHCCCCCCCCCCCC		59.91-
445UbiquitinationDKNGMPVEPKPEPEK
CCCCCCCCCCCCCCC		41.5621890473
447UbiquitinationNGMPVEPKPEPEKHK
CCCCCCCCCCCCCCC		48.81-
454UbiquitinationKPEPEKHKDSLNMWL
CCCCCCCCCCCCEEE		61.14-
456PhosphorylationEPEKHKDSLNMWLCP
CCCCCCCCCCEEEEC		26.8422617229
456O-linked_GlycosylationEPEKHKDSLNMWLCP
CCCCCCCCCCEEEEC		26.8430379171
465UbiquitinationNMWLCPRKEVIEQTK
CEEEECHHHHHHHCC		41.28-
472PhosphorylationKEVIEQTKAPKAMTP
HHHHHHCCCCCCCCH		63.4927251275
472UbiquitinationKEVIEQTKAPKAMTP
HHHHHHCCCCCCCCH		63.4921906983
472 (in isoform 1)Ubiquitination-63.4921890473
475UbiquitinationIEQTKAPKAMTPSRI
HHHCCCCCCCCHHHH		56.50-
478PhosphorylationTKAPKAMTPSRIADS
CCCCCCCCHHHHHHH		23.9922199227
480PhosphorylationAPKAMTPSRIADSFQ
CCCCCCHHHHHHHHH		27.4422199227
485PhosphorylationTPSRIADSFQVIKNS
CHHHHHHHHHHHCCC		14.4624850871
490UbiquitinationADSFQVIKNSPLSEW
HHHHHHHCCCCHHHH		53.1421906983
490 (in isoform 1)Ubiquitination-53.1421890473
492PhosphorylationSFQVIKNSPLSEWLI
HHHHHCCCCHHHHCC		23.4025159151
504UbiquitinationWLIRPPYKEGSPKEV
HCCCCCCCCCCCCCC		62.46-
507PhosphorylationRPPYKEGSPKEVPGT
CCCCCCCCCCCCCCC		33.6126055452
509UbiquitinationPYKEGSPKEVPGTED
CCCCCCCCCCCCCCC		73.39-
514PhosphorylationSPKEVPGTEDRAGKQ
CCCCCCCCCCCCCHH		28.7426425664
520UbiquitinationGTEDRAGKQKFKSPM
CCCCCCCHHCCCCCC		49.70-
529PhosphorylationKFKSPMNTSWCSFNT
CCCCCCCCCCEECCC		19.8328348404
530PhosphorylationFKSPMNTSWCSFNTA
CCCCCCCCCEECCCC		22.5322617229
533PhosphorylationPMNTSWCSFNTADWV
CCCCCCEECCCCCEE		18.4428348404
536PhosphorylationTSWCSFNTADWVLPG
CCCEECCCCCEECCC		24.7928348404
544UbiquitinationADWVLPGKKMGNLSQ
CCEECCCCCCCCHHH		37.33-
545UbiquitinationDWVLPGKKMGNLSQL
CEECCCCCCCCHHHC		58.94-
550PhosphorylationGKKMGNLSQLSSGED
CCCCCCHHHCCCCCC		32.8327050516
552PhosphorylationKMGNLSQLSSGEDKW
CCCCHHHCCCCCCHH		3.8527251275
553PhosphorylationMGNLSQLSSGEDKWL
CCCHHHCCCCCCHHH		28.7629514088
554PhosphorylationGNLSQLSSGEDKWLL
CCHHHCCCCCCHHHH		55.5927050516
558UbiquitinationQLSSGEDKWLLRKKA
HCCCCCCHHHHHHHH		35.122190698
558 (in isoform 1)Ubiquitination-35.1221890473
603UbiquitinationCMQLKVDKEKWLYRT
HHCCCCCHHHHHHCC		65.27-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NCOA4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NCOA4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NCOA4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ANDR_HUMANARphysical
9636157
ANDR_HUMANARphysical
11404460
ANDR_HUMANARphysical
9892017
ESR1_HUMANESR1physical
9892017
GCR_RATNr3c1physical
9892017
ANDR_HUMANARphysical
10318905
TF2B_HUMANGTF2Bphysical
9892017
KAT2B_HUMANKAT2Bphysical
9892017
ANDR_HUMANARphysical
11818501
ANDR_HUMANARphysical
10517667
GCR_HUMANNR3C1physical
10517667
VDR_HUMANVDRphysical
15805579
FRIH_HORSEFTH1physical
26436293
FRIH_HUMANFTH1physical
26436293
HERC2_HUMANHERC2physical
26436293
FRIL_HUMANFTLphysical
28514442
GMCL1_HUMANGMCL1physical
28514442
HERC2_HUMANHERC2physical
28514442
NEUL4_HUMANNEURL4physical
28514442
TAXB1_HUMANTAX1BP1physical
28877469
FRIH_HUMANFTH1physical
28877469
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
188550Thyroid papillary carcinoma (TPC)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NCOA4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456, AND MASSSPECTROMETRY.

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