PITC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PITC1_HUMAN
• UniProt AC: Q9UKF7
• Protein Name: Cytoplasmic phosphatidylinositol transfer protein 1
• Gene Name: PITPNC1
• Organism: Homo sapiens (Human).
• Sequence Length: 332
• Subcellular Localization: Cytoplasm .
• Protein Description: Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro..
• Protein Sequence: MLLKEYRICMPLTVDEYKIGQLYMISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNLPGMHSSDKPCRPKSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Sumoylation	----MLLKEYRICMP ----CCCCEEEEEEE	49.06	-
4	Sumoylation	----MLLKEYRICMP ----CCCCEEEEEEE	49.06	-
119	Phosphorylation	KYEDNKGSNDTIFDN ECCCCCCCCCCCCCC	32.89	25307156
122	Phosphorylation	DNKGSNDTIFDNEAK CCCCCCCCCCCCCHH	28.00	25307156
129	Ubiquitination	TIFDNEAKDVEREVC CCCCCCHHHHCEEEE	57.01	-
254 (in isoform 2)	Phosphorylation	-	31.32	28270605
255 (in isoform 2)	Phosphorylation	-	14.38	28450419
266 (in isoform 2)	Phosphorylation	-	41.24	28450419
267 (in isoform 2)	Phosphorylation	-	21.43	28450419
268 (in isoform 2)	Phosphorylation	-	7.04	28450419
270	Phosphorylation	LLPSSVRSAPSSAPS CCCCCCCCCCCCCCC	42.23	29255136
273	Phosphorylation	SSVRSAPSSAPSTPL CCCCCCCCCCCCCCC	38.56	29255136
274	Phosphorylation	SVRSAPSSAPSTPLS CCCCCCCCCCCCCCC	43.04	29255136
277	Phosphorylation	SAPSSAPSTPLSTDA CCCCCCCCCCCCCCC	42.23	29255136
278	Phosphorylation	APSSAPSTPLSTDAP CCCCCCCCCCCCCCC	27.47	29255136
281	Phosphorylation	SAPSTPLSTDAPEFL CCCCCCCCCCCCCHH	25.99	29255136
282	Phosphorylation	APSTPLSTDAPEFLS CCCCCCCCCCCCHHC	43.81	29255136
289	Phosphorylation	TDAPEFLSVPKDRPR CCCCCHHCCCCCCCC	41.51	29255136
299	Phosphorylation	KDRPRKKSAPETLTL CCCCCCCCCCCCCCC	52.68	19664994
303	Phosphorylation	RKKSAPETLTLPDPE CCCCCCCCCCCCCHH	24.80	30266825
305	Phosphorylation	KSAPETLTLPDPEKK CCCCCCCCCCCHHHC	43.60	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
274	S	Phosphorylation	Kinase	PKCA	P17252	PSP
299	S	Phosphorylation	Kinase	PKCA	P17252	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PITC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PITC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATRAP_HUMAN	AGTRAP	physical	16189514
ATRAP_MOUSE	Agtrap	physical	21728994
ATRAP_HUMAN	AGTRAP	physical	19060904
ATRAP_HUMAN	AGTRAP	physical	25416956
CKLF5_HUMAN	CMTM5	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.