RNF10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNF10_MOUSE
• UniProt AC: Q3UIW5
• Protein Name: RING finger protein 10
• Gene Name: Rnf10
• Organism: Mus musculus (Mouse).
• Sequence Length: 804
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression and myelin formation in Schwann cells..
• Protein Sequence: MPQSSPSAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSNGSKRYNRKREPSYPKNENFSNQSRRSNSQKSKTFNKMPPQRGGGSSKPFSSSSNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQAGHFEGSGHGGWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYAAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLKSVVATESRQYAVGDTITMQLMKREKGVLVALPKSKWVNVDHPINLGDEQLSQYSKLLLASKEQVLHRVVLEEKGALEQQLAEEKHTPESCFIEAAIQEVKIREEALSGVAGGGGEVTGVVAALEHLVLMAPLATESAFQPRKGVLEYLSAFDDEAAQVCSLDPPGPLALPLVEEEEAVSEPEACEDAEVADDSLGEGTVGPEMSQEEPITKPGFTQLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLEQSPEKISATVVEIAGYSMSEDVRQRHRYLSHLPLTCEFSICELALQPPVVSKETLEMFSDDIEKRKRQRQKKAREERRRERRIEMEENKRQGRYPEVHIPLENLQQFPAFNSYTCPSDSALGPTSTEGHGALSLSPLSRSPGSHADFLLTPLSPTASQGSPSFCVGSLEDDSPFLSFAQMLRVGKAKADGWPKTAPKKDDNSLVPPAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPATSDPLSEDRGGKKRKRQKQKLLFSTSVVHTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPQSSPSAAAT ----CCCCCHHHCCC	38.04	26643407
5	Phosphorylation	---MPQSSPSAAATA ---CCCCCHHHCCCH	20.02	26643407
11	Phosphorylation	SSPSAAATASDMDKN CCHHHCCCHHHCCCC	23.20	29109428
13	Phosphorylation	PSAAATASDMDKNSG HHHCCCHHHCCCCCC	29.16	29109428
39	Phosphorylation	KGQQPPRSASAGPAG CCCCCCCCCCCCCCC	32.14	30635358
41	Phosphorylation	QQPPRSASAGPAGES CCCCCCCCCCCCCCC	34.70	25266776
48	Phosphorylation	SAGPAGESKPKSDGK CCCCCCCCCCCCCCC	54.03	30635358
78	Phosphorylation	YPKNENFSNQSRRSN CCCCCCCCCHHHHCC	45.61	23375375
81	Phosphorylation	NENFSNQSRRSNSQK CCCCCCHHHHCCCCC	33.63	30635358
105	Ubiquitination	QRGGGSSKPFSSSSN CCCCCCCCCCCCCCC	52.35	-
110	Phosphorylation	SSKPFSSSSNGGRRD CCCCCCCCCCCCCHH	26.99	-
128	Phosphorylation	EAQRAEFSPAQFSGP HHHHHHCCCCHHCCC	15.72	25266776
136	Ubiquitination	PAQFSGPKKINLNHL CCHHCCCCEECCCCE	70.57	-
283	Phosphorylation	KSVVATESRQYAVGD HHHEECCCHHHHHCC	21.96	-
310	Phosphorylation	VLVALPKSKWVNVDH EEEEEECCCCCCCCC	29.79	-
730	Phosphorylation	APKKDDNSLVPPAPV CCCCCCCCCCCCCCC	37.43	25293948
739	Phosphorylation	VPPAPVDSDGESDNS CCCCCCCCCCCCCCC	47.99	25293948
743	Phosphorylation	PVDSDGESDNSDRVP CCCCCCCCCCCCCCC	47.85	25293948
746	Phosphorylation	SDGESDNSDRVPVPS CCCCCCCCCCCCCHH	31.61	25293948
753	Phosphorylation	SDRVPVPSFQNSFSQ CCCCCCHHHHHHHHH	39.43	25293948
757	Phosphorylation	PVPSFQNSFSQAIEA CCHHHHHHHHHHHHH	18.58	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
31	S	Phosphorylation	Kinase	PKCA	P05696	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNF10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNF10_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RNF10_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.