dbPTM

SC24A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SC24A_MOUSE
UniProt AC	Q3U2P1
Protein Name	Protein transport protein Sec24A {ECO:0000305}
Gene Name	Sec24a {ECO:0000312\|MGI:MGI:1924621}
Organism	Mus musculus (Mouse).
Sequence Length	1090
Subcellular Localization	Cytoplasmic vesicle, COPII-coated vesicle membrane Peripheral membrane protein Cytoplasmic side . Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side . Cytoplasm, cytosol .
Protein Description	Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes..
Protein Sequence	MAQPRIPAARGAAASLQAQNGAASASGSPYTNGPVHNTLMSPQVSSSQGYDSQPPGSYPRPMPAKTLNPFSAQSNYGGSQGSGQTLNSPLVTSGPVLPSLHSGPVPRMPLPTSQNPAATPMPSGSFLPGANPPPPLNWQYNYPSTGPQTNHFPHVAPPTLPGNPNLTADHQYVSSGDPALQTSFKKPGSALPLQNPPLPPTFQPGAPPGPPPAGGPPPSRGPAPQKTPPRAAPPPSFNSAVNQEGITSNANNGSTAAHNTYDEIEGGGFLATPQLVNQNPKTSRSVGSAYPSLPPGYQNSAPPVAGMPPPSLSYPSGPQAFTQTPLGANHLTASMSGLSLHPEGLRVVNLLQERNMLPSTPLQPPVPNLLEDIQKLNCNPELFRCTLTSVPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVNFLDQRRWKCNLCYRVNDVPEEFMYNPLTRVYGEPHKRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAIETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYSLQEGLSQPQMLIVSDIDDVFIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLISPTGGRMSVFQTQLPTLGVGALKPREEPNQRSSAKEIHLTPSTDFYKKLALDCSGQQAAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQKELHRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNEVFLGADVQAISGLLANMAVDRSVTASLSDARDALVNAVIDSLSAYRSSVLSGQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTSIRLDERIFAMCQVKSQPLVHLMLTTHPSLYRVDNLSDEGALNINDRTIPQPPILQLSVEKLSRDGAFLMDAGSLLMLWVGRNCSQNFLSQVLGVQNYASIPQTMTDLPELDTPESARIAAFISWLREQRPFFPVLYVIREESLMKAAFLQSLVEDRTESALSYYEFLLHIQQQVNK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
226	Malonylation	SRGPAPQKTPPRAAP CCCCCCCCCCCCCCC	63.04	26320211
227	Phosphorylation	RGPAPQKTPPRAAPP CCCCCCCCCCCCCCC	33.02	26824392
375	Ubiquitination	NLLEDIQKLNCNPEL CHHHHHHHCCCCHHH	41.84	-
399	Ubiquitination	QTQALLNKAKLPLGL HHHHHHHHCCCCHHH	47.03	22790023
401	Acetylation	QALLNKAKLPLGLLL HHHHHHCCCCHHHHH	52.85	23806337
401	Succinylation	QALLNKAKLPLGLLL HHHHHHCCCCHHHHH	52.85	23806337
421	Phosphorylation	LVQLPVVTSSTIVRC HCCCCCCCCCCEEEE	19.73	28059163
448	Malonylation	FLDQRRWKCNLCYRV HHHHCCCCCCEEEEE	16.07	26320211
448	Ubiquitination	FLDQRRWKCNLCYRV HHHHCCCCCCEEEEE	16.07	-
605	Ubiquitination	TLPQMFTKTLETQSA HHHHHHHHHHHHHHH	39.59	22790023
647	Ubiquitination	TLGVGALKPREEPNQ CCCCCCCCCCCCCCC	41.30	22790023
659	Ubiquitination	PNQRSSAKEIHLTPS CCCCCCCCEEECCCC	60.18	22790023
671	Succinylation	TPSTDFYKKLALDCS CCCCHHHHHHCCCCC	41.10	23954790
671	Acetylation	TPSTDFYKKLALDCS CCCCHHHHHHCCCCC	41.10	23954790
907	Ubiquitination	VLALLKQKSFQTGTS HHHHHHCCCCCCCCC	52.21	22790023
974	Ubiquitination	ILQLSVEKLSRDGAF EEEEEHHHHCCCCCE	50.00	22790023
1050	Phosphorylation	RPFFPVLYVIREESL CCCCCEEEEECHHHH	8.28	20116462

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SC24A_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SC24A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SC24A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SC24A_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SC24A_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis."; Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.; J. Proteome Res. 7:3957-3967(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-227, AND MASSSPECTROMETRY.	18630941 [Abstract]