IMP4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMP4_MOUSE
• UniProt AC: Q8VHZ7
• Protein Name: U3 small nucleolar ribonucleoprotein protein IMP4
• Gene Name: Imp4
• Organism: Mus musculus (Mouse).
• Sequence Length: 291
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity)..
• Protein Sequence: MLRREARLRREYLYRKAREEAQRSVQEKKERVKRALEENQLIPTELRREALALQGSLEFDDAGGEGVTSHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTMSEAKPHLITHGFSSRLGKRVSDILRYLFPVPKDDSHRVITFANQDDYISFRHHVYKKTDHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTARKRVFLSAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	EENQLIPTELRREAL HHCCCCCHHHHHHHH	40.43	28507225
56	Phosphorylation	EALALQGSLEFDDAG HHHHHCCCEECCCCC	16.27	30635358
89	Phosphorylation	DPKVMITTSRDPSSR CCCEEEECCCCHHHH	15.73	28576409
278	Phosphorylation	VEWRWHPYTNTARKR CEEEEECCCCCCCCE	10.35	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMP4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMP4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMP4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IMP4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.