LEG1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LEG1_MOUSE
• UniProt AC: P16045
• Protein Name: Galectin-1
• Gene Name: Lgals1
• Organism: Mus musculus (Mouse).
• Sequence Length: 135
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis..
• Protein Sequence: MACGLVASNLNLKPGECLKVRGEVASDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNTKEDGTWGTEHREPAFPFQPGSITEVCITFDQADLTIKLPDGHEFKFPNRLNMEAINYMAADGDFKIKCVAFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MACGLVASN ------CCCCCEEEC	8.97	-
8	Phosphorylation	MACGLVASNLNLKPG CCCCCEEECCCCCCC	34.08	26824392
13	Succinylation	VASNLNLKPGECLKV EEECCCCCCCCEEEE	50.32	23806337
13	Acetylation	VASNLNLKPGECLKV EEECCCCCCCCEEEE	50.32	23806337
19	Acetylation	LKPGECLKVRGEVAS CCCCCEEEEEEEECC	41.36	23806337
19	Succinylation	LKPGECLKVRGEVAS CCCCCEEEEEEEECC	41.36	23806337
26	Phosphorylation	KVRGEVASDAKSFVL EEEEEECCCCCEEEE	43.19	24899341
29	Acetylation	GEVASDAKSFVLNLG EEECCCCCEEEEEEC	49.79	23806337
29	Ubiquitination	GEVASDAKSFVLNLG EEECCCCCEEEEEEC	49.79	-
29	Succinylation	GEVASDAKSFVLNLG EEECCCCCEEEEEEC	49.79	23806337
30	Phosphorylation	EVASDAKSFVLNLGK EECCCCCEEEEEECC	23.47	25521595
37	Ubiquitination	SFVLNLGKDSNNLCL EEEEEECCCCCCEEE	62.24	22790023
37	Acetylation	SFVLNLGKDSNNLCL EEEEEECCCCCCEEE	62.24	22826441
39	Phosphorylation	VLNLGKDSNNLCLHF EEEECCCCCCEEEEE	30.98	26745281
43	S-palmitoylation	GKDSNNLCLHFNPRF CCCCCCEEEEECCCC	2.78	26165157
43	Glutathionylation	GKDSNNLCLHFNPRF CCCCCCEEEEECCCC	2.78	24333276
43	S-nitrosylation	GKDSNNLCLHFNPRF CCCCCCEEEEECCCC	2.78	20925432
43	S-nitrosocysteine	GKDSNNLCLHFNPRF CCCCCCEEEEECCCC	2.78	-
61	Glutathionylation	GDANTIVCNTKEDGT CCCCEEEEECCCCCC	4.77	24333276
61	S-nitrosylation	GDANTIVCNTKEDGT CCCCEEEEECCCCCC	4.77	20925432
61	S-palmitoylation	GDANTIVCNTKEDGT CCCCEEEEECCCCCC	4.77	26165157
61	S-nitrosocysteine	GDANTIVCNTKEDGT CCCCEEEEECCCCCC	4.77	-
63	Phosphorylation	ANTIVCNTKEDGTWG CCEEEEECCCCCCCC	30.59	19854140
64	Acetylation	NTIVCNTKEDGTWGT CEEEEECCCCCCCCC	39.56	22826441
108	Succinylation	LPDGHEFKFPNRLNM CCCCCCEECCCCCCH	57.85	23806337
108	Ubiquitination	LPDGHEFKFPNRLNM CCCCCCEECCCCCCH	57.85	-
108	Succinylation	LPDGHEFKFPNRLNM CCCCCCEECCCCCCH	57.85	-
108	Acetylation	LPDGHEFKFPNRLNM CCCCCCEECCCCCCH	57.85	23806337
120	Phosphorylation	LNMEAINYMAADGDF CCHHHHHHHCCCCCC	5.09	25777480
128	Acetylation	MAADGDFKIKCVAFE HCCCCCCEEEEEEEC	46.10	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LEG1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LEG1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LEG1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LEG1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.