PRP6_MOUSE - dbPTM
PRP6_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRP6_MOUSE
UniProt AC Q91YR7
Protein Name Pre-mRNA-processing factor 6
Gene Name Prpf6
Organism Mus musculus (Mouse).
Sequence Length 941
Subcellular Localization Nucleus, nucleoplasm. Nucleus speckle. Localized in splicing speckles..
Protein Description Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation..
Protein Sequence MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQMKKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENNEYERARRLLAKARSSAPTARVFMKSVKLEWVLGNISAAQELCEEALRHYEDFPKLWMMKGQIEEQGELMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAVFLEARPQRKTKSVDALKKCEHDPHVLLAVAKLFWSERKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCENAEPRHGELWCAVSKDITNWQRKIGEILVLVAARIKNTF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationGMPAPLGYVPGLGRG
CCCCCCCCCCCCCCC		15.91-
31DimethylationGATGFTTRSDIGPAR
CCCCCCCHHHCCCCC		29.31-
31MethylationGATGFTTRSDIGPAR
CCCCCCCHHHCCCCC		29.31115383815
131PhosphorylationEKEEIEKYRMERPKI
HHHHHHHHHHHCHHH		11.47-
143PhosphorylationPKIQQQFSDLKRKLA
HHHHHHHHHHHHHHH		37.3825338131
178UbiquitinationQRNPRYEKLTPVPDS
CCCCCCHHCCCCCCC		49.0422790023
180PhosphorylationNPRYEKLTPVPDSFF
CCCCHHCCCCCCCHH		33.05-
256PhosphorylationTLMDMRLSQVSDSVS
HHHHHHHHHCCCCCC		20.4025619855
259PhosphorylationDMRLSQVSDSVSGQT
HHHHHHCCCCCCCCE		19.2825619855
261PhosphorylationRLSQVSDSVSGQTVV
HHHHCCCCCCCCEEE		15.6325619855
263PhosphorylationSQVSDSVSGQTVVDP
HHCCCCCCCCEEECC		29.1825619855
266PhosphorylationSDSVSGQTVVDPKGY
CCCCCCCEEECCCCC		26.4825521595
273PhosphorylationTVVDPKGYLTDLNSM
EEECCCCCCCCHHHC		16.7425619855
275PhosphorylationVDPKGYLTDLNSMIP
ECCCCCCCCHHHCCC		29.9227087446
279PhosphorylationGYLTDLNSMIPTHGG
CCCCCHHHCCCCCCC		25.9427087446
283PhosphorylationDLNSMIPTHGGDIND
CHHHCCCCCCCCHHH		23.4125619855
322PhosphorylationSARLEEVTGKLQVAR
HHCHHHHHCHHHHHH		31.7025777480
334UbiquitinationVARNLIMKGTEMCPK
HHHHHHHHCCCCCCC		56.5422790023
336PhosphorylationRNLIMKGTEMCPKSE
HHHHHHCCCCCCCCH		18.2828059163
606AcetylationRAVAHCPKAEVLWLM
HHHHCCCHHHHHHHH		63.6722826441
670PhosphorylationRLLAKARSSAPTARV
HHHHHHHCCCCCHHH		35.3920495213
727UbiquitinationEQGELMEKAREAYNQ
HHHHHHHHHHHHHHH		38.4922790023
739S-nitrosylationYNQGLKKCPHSTPLW
HHHHHHCCCCCCHHH		3.3320925432
739S-nitrosocysteineYNQGLKKCPHSTPLW
HHHHHHCCCCCCHHH		3.33-
768UbiquitinationRARAILEKSRLKNPK
HHHHHHHHHCCCCCC		37.11-
837S-nitrosylationSVDALKKCEHDPHVL
CHHHHHHCCCCHHHH		5.5520925432
837S-nitrosocysteineSVDALKKCEHDPHVL
CHHHHHHCCCCHHHH		5.55-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRP6_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRP6_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRP6_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PRP6_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRP6_MOUSE

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Related Literatures of Post-Translational Modification

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