PTN14_MOUSE - dbPTM
PTN14_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTN14_MOUSE
UniProt AC Q62130
Protein Name Tyrosine-protein phosphatase non-receptor type 14
Gene Name Ptpn14
Organism Mus musculus (Mouse).
Sequence Length 1189
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane..
Protein Description Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor..
Protein Sequence MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSRLQQEATRYQYYLQVKKDVLEGRLRCSLEQVIRLAGLAVQADFGDYNQFDSQEFLREYVLFPMDLAMEEAALEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDSHGNSVHLGIFFMGIFVRNRVGRQAVIYRWNDIGSVTHSKAAILLELIDKEETALFHTDDIENAKYISRLFTTRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPMHVQCSEHYSETHTSQDSIFPGNEEALYCRSHNSLDLNYLNGTVTNGSVCSVHSVNSLSCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSTIIVPSYRPTPDYETVMRQMKRGLMHADSQSRSLRNLNIINTHAYNQPEELVYSQPEMRERHPYTVPYAHQGCYGHKLVSPSDQMNPQNCAMPIKPGASSISHTVSTPELANMQLQGAQHYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGGGGGTVNKRHSLEVMNSMVRGMEAMTLKSLNIPMARRNTLREQGPSEETGGHEVHGLPQYHHKKTFSDATMLIHSSESEEEEETLEAAPQVPVLREKVEYSAQLQAALARIPNRPPPEYPGPRKSVSNGALRQDQGTPLPAMARCRVLRHGPSKALSVSRAEQLAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMTGPQAQKRPLMLAALNGLSVARVSGREDGHHDATRVPIDERLRALKKKLEDGMVFTEYEQIPNKKANGVFSTATLPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGSEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSGCYATTGLKVKHLLSGQERTVWHLQYTDWPHHGCPEDVQGFLSYLEEIQSVRRHTNSVLEGIRTRHPPIVVHCSAGVGRTGVVILSELMIYCLEHNEKVEVPTMLRFLREQRMFMIQTIAQYKFVYQVLVQFLQNSRLI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
309PhosphorylationYKQNKICTEQSNSPP
HHHCCCCCCCCCCCC		40.3025619855
312PhosphorylationNKICTEQSNSPPPIR
CCCCCCCCCCCCCCC		32.8025619855
314PhosphorylationICTEQSNSPPPIRRQ
CCCCCCCCCCCCCCC		43.9927087446
323PhosphorylationPPIRRQPTWSRSSLP
CCCCCCCCCCCCCCC		27.9529514104
327PhosphorylationRQPTWSRSSLPRQQP
CCCCCCCCCCCCCCC		30.6123737553
328PhosphorylationQPTWSRSSLPRQQPY
CCCCCCCCCCCCCCC		41.0823737553
425PhosphorylationSDIMRADYIPSHRHS
HHHCCCCCCCCCCCC		17.4729514104
428PhosphorylationMRADYIPSHRHSTII
CCCCCCCCCCCCEEE		24.4826060331
432PhosphorylationYIPSHRHSTIIVPSY
CCCCCCCCEEEECCC		22.6622817900
433PhosphorylationIPSHRHSTIIVPSYR
CCCCCCCEEEECCCC		14.4829550500
442PhosphorylationIVPSYRPTPDYETVM
EECCCCCCCCHHHHH		21.5729514104
445PhosphorylationSYRPTPDYETVMRQM
CCCCCCCHHHHHHHH		18.0729514104
447PhosphorylationRPTPDYETVMRQMKR
CCCCCHHHHHHHHHH		17.2429514104
461PhosphorylationRGLMHADSQSRSLRN
HCCCCCCHHCHHHCC		30.7326824392
463PhosphorylationLMHADSQSRSLRNLN
CCCCCHHCHHHCCCC		27.9922817900
465PhosphorylationHADSQSRSLRNLNII
CCCHHCHHHCCCCEE		36.6126824392
485PhosphorylationNQPEELVYSQPEMRE
CCCHHHCCCCHHHHH		17.7626239621
486PhosphorylationQPEELVYSQPEMRER
CCHHHCCCCHHHHHH		31.6027087446
496PhosphorylationEMRERHPYTVPYAHQ
HHHHHCCCCCCCCCC		17.7829514104
570PhosphorylationLFRPPPPYPRPRPAT
HCCCCCCCCCCCCCC		20.0426060331
577PhosphorylationYPRPRPATSTPDLAS
CCCCCCCCCCCCHHH		35.5025263469
578PhosphorylationPRPRPATSTPDLASH
CCCCCCCCCCCHHHC		39.8026824392
579PhosphorylationRPRPATSTPDLASHR
CCCCCCCCCCHHHCC		19.2326824392
584PhosphorylationTSTPDLASHRHKYVS
CCCCCHHHCCHHCCC		28.4926160508
589PhosphorylationLASHRHKYVSGSSPD
HHHCCHHCCCCCCCC		8.1725619855
591PhosphorylationSHRHKYVSGSSPDLV
HCCHHCCCCCCCCHH		29.8421082442
593PhosphorylationRHKYVSGSSPDLVTR
CHHCCCCCCCCHHHC		31.0627087446
594PhosphorylationHKYVSGSSPDLVTRK
HHCCCCCCCCHHHCE		26.4227087446
599PhosphorylationGSSPDLVTRKVQLSV
CCCCCHHHCEEEEEE		31.8825619855
605PhosphorylationVTRKVQLSVKTFQED
HHCEEEEEEEECCCC		12.4127600695
608PhosphorylationKVQLSVKTFQEDSSP
EEEEEEEECCCCCCC		28.5325619855
613PhosphorylationVKTFQEDSSPVVHQS
EEECCCCCCCHHHHH		35.4725619855
614PhosphorylationKTFQEDSSPVVHQSL
EECCCCCCCHHHHHH		33.7525619855
620PhosphorylationSSPVVHQSLQEVSEP
CCCHHHHHHHHHCCC		19.6926824392
625PhosphorylationHQSLQEVSEPLTATK
HHHHHHHCCCCCCCC		32.5125619855
629PhosphorylationQEVSEPLTATKHHGG
HHHCCCCCCCCCCCC		42.8925619855
631PhosphorylationVSEPLTATKHHGGGG
HCCCCCCCCCCCCCC		26.1925619855
646PhosphorylationGTVNKRHSLEVMNSM
CCCCHHHHHHHHHHH		30.2026824392
652PhosphorylationHSLEVMNSMVRGMEA
HHHHHHHHHHCHHHH		10.6820139300
674PhosphorylationIPMARRNTLREQGPS
CCCHHHCCHHHHCCC		25.9426060331
695PhosphorylationEVHGLPQYHHKKTFS
CCCCCCCCCCCCCCC		12.1729514104
710PhosphorylationDATMLIHSSESEEEE
CCEEEECCCCCHHHH		28.8925338131
711PhosphorylationATMLIHSSESEEEEE
CEEEECCCCCHHHHH		30.8625338131
713PhosphorylationMLIHSSESEEEEETL
EEECCCCCHHHHHHH		52.8625338131
759AcetylationPEYPGPRKSVSNGAL
CCCCCCCCCCCCCCC		59.3415614323
760PhosphorylationEYPGPRKSVSNGALR
CCCCCCCCCCCCCCC		31.8627087446
762PhosphorylationPGPRKSVSNGALRQD
CCCCCCCCCCCCCCC		36.3227087446
772PhosphorylationALRQDQGTPLPAMAR
CCCCCCCCCCHHHHH		18.9329514104
792PhosphorylationHGPSKALSVSRAEQL
CCCCCCCCCHHHHHH		23.9426160508
794PhosphorylationPSKALSVSRAEQLAV
CCCCCCCHHHHHHHH		23.5426160508
805PhosphorylationQLAVNGASLGPSISE
HHHHCCCCCCCCCCC		34.9525619855
809PhosphorylationNGASLGPSISEPDLT
CCCCCCCCCCCCCCH		36.6325619855
811PhosphorylationASLGPSISEPDLTSV
CCCCCCCCCCCCHHH		47.6227087446
816PhosphorylationSISEPDLTSVKERVK
CCCCCCCHHHHHHHH		38.5625619855
817PhosphorylationISEPDLTSVKERVKK
CCCCCCHHHHHHHHC		38.1925619855
833PhosphorylationPVKERPVSEMFSLED
CCCCCCHHHCCCHHH		26.4827087446
837PhosphorylationRPVSEMFSLEDSIIE
CCHHHCCCHHHHHHH		29.5526239621
841PhosphorylationEMFSLEDSIIEREMM
HCCCHHHHHHHHHHH		18.9826370283
856AcetylationIRNLEKQKMTGPQAQ
HHHHHHHCCCCHHHH		49.8819843383
864AcetylationMTGPQAQKRPLMLAA
CCCHHHHHCHHHHHH		60.0219843393
876PhosphorylationLAALNGLSVARVSGR
HHHHCCCEEEEECCC		18.3526824392
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTN14_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTN14_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTN14_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PTN14_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTN14_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-593 AND SER-594, ANDMASS SPECTROMETRY.

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