SND1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SND1_MOUSE
• UniProt AC: Q78PY7
• Protein Name: Staphylococcal nuclease domain-containing protein 1
• Gene Name: Snd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 910
• Subcellular Localization: Cytoplasm. Nucleus. Melanosome. In IL-4 stimulated cells colocalizes with STAT6 in the nucleus..
• Protein Description: Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Plays a role in cell viability (By similarity). Functions as a transcriptional coactivator for STAT5..
• Protein Sequence: MASSAQSSGSSGGPAVPTVQRGIVKMVLSGCAIIVRGQPRGGPPPERQINLSNIRAGNLARRAAATQPDGKDTPDEPWAFPAREFLRKKLIGKEVCFTIENKTPQGREYGMIYLGKDTNGENIAESLVAEGLATRREGMRANNPEQNRLSECEEQAKASKKGMWSEGNGSHTIRDLKYTIENPRHFVDSHHQKPVNAIIEHVRDGSVVRALLLPGHHLVTVMLSGIKCPTFRRETDGSETPEPFAAEAKFFTESRLLQRDVQIILESCHNQNLLGTILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLRAAERFAKERRLRIWRDYVPPTANLDQKDKQFVAKVMQVLNADAIVVKLNSGDYKTIHLSSIRPPRLEGDNIQDKNKKLRPLYDIPYMFEAREFLRKKLIGKKVNVTVDYIRPASPATETVPAFSERTCATVTIGGINIAEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKKEVPIHRVADISGDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECPRGARNLPGLVQEGEPFSEEATLFTKELVLQREVEVEVESMDKAGNFIGWLHMDGANLSVLLVEQALSKVHFTAERSAYYKPLLSAEEAAKQRKEKVWAHYEERPVEEVMPVLEEKERSASYKPVFVTEITDDLHFYVQDVETGTQLEKLMENMRNDISSHPPVEGSYAPRRGEFCIAKFVDGEWYRARVEKVESPAKVHVFYIDYGNREILPSTRLGTLPPAFSTRVLPAQATEYAFAFIQVPQDEDARTDAVDSVVRDIQNTQCLLNVEHLSASCPHVTLQFADSKGDVGLGLVKEGLVMVEVRKEKQFQKVITEYLNAQESAKSARLNLWRYGDFRADDADEFGYSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASSAQSSG ------CCCCCCCCC	16.52	-
3	Phosphorylation	-----MASSAQSSGS -----CCCCCCCCCC	25.55	29472430
4	Phosphorylation	----MASSAQSSGSS ----CCCCCCCCCCC	22.31	29514104
7	Phosphorylation	-MASSAQSSGSSGGP -CCCCCCCCCCCCCC	36.06	29514104
8	Phosphorylation	MASSAQSSGSSGGPA CCCCCCCCCCCCCCC	30.52	29514104
10	Phosphorylation	SSAQSSGSSGGPAVP CCCCCCCCCCCCCCC	27.97	29472430
11	Phosphorylation	SAQSSGSSGGPAVPT CCCCCCCCCCCCCCC	51.82	24759943
31	S-nitrosylation	VKMVLSGCAIIVRGQ HHHHHCCCEEEECCC	1.90	22178444
52	Phosphorylation	PERQINLSNIRAGNL CHHHCCCCHHHHCHH	26.23	-
71	Malonylation	AATQPDGKDTPDEPW HHCCCCCCCCCCCCC	66.85	26320211
71	Ubiquitination	AATQPDGKDTPDEPW HHCCCCCCCCCCCCC	66.85	-
96	S-nitrosocysteine	KLIGKEVCFTIENKT HCCCCEEEEEEECCC	2.33	-
96	S-nitrosylation	KLIGKEVCFTIENKT HCCCCEEEEEEECCC	2.33	22178444
96	S-palmitoylation	KLIGKEVCFTIENKT HCCCCEEEEEEECCC	2.33	28526873
102	Malonylation	VCFTIENKTPQGREY EEEEEECCCCCCCEE	49.11	26320211
102	Ubiquitination	VCFTIENKTPQGREY EEEEEECCCCCCCEE	49.11	-
103	Phosphorylation	CFTIENKTPQGREYG EEEEECCCCCCCEEE	32.21	26824392
109	Phosphorylation	KTPQGREYGMIYLGK CCCCCCEEEEEEECC	15.61	21082442
113	Phosphorylation	GREYGMIYLGKDTNG CCEEEEEEECCCCCC	10.66	25367039
126	Phosphorylation	NGENIAESLVAEGLA CCCCHHHHHHHHHHH	21.08	29514104
150	Phosphorylation	NPEQNRLSECEEQAK CHHHCCHHHHHHHHH	36.64	26824392
152	S-nitrosylation	EQNRLSECEEQAKAS HHCCHHHHHHHHHHH	6.65	20925432
152	S-nitrosocysteine	EQNRLSECEEQAKAS HHCCHHHHHHHHHHH	6.65	-
152	Glutathionylation	EQNRLSECEEQAKAS HHCCHHHHHHHHHHH	6.65	24333276
177	Acetylation	SHTIRDLKYTIENPR CCCCEEEEEEECCCC	44.64	133773
177	Ubiquitination	SHTIRDLKYTIENPR CCCCEEEEEEECCCC	44.64	-
193	Acetylation	FVDSHHQKPVNAIIE HCCCCCCCCHHHHHH	46.72	-
193	Malonylation	FVDSHHQKPVNAIIE HCCCCCCCCHHHHHH	46.72	26320211
228	S-nitrosocysteine	VMLSGIKCPTFRRET EEECCCCCCCEECCC	3.47	-
228	S-nitrosylation	VMLSGIKCPTFRRET EEECCCCCCCEECCC	3.47	20925432
230	Phosphorylation	LSGIKCPTFRRETDG ECCCCCCCEECCCCC	38.96	20469934
235	Phosphorylation	CPTFRRETDGSETPE CCCEECCCCCCCCCC	43.80	25521595
238	Phosphorylation	FRRETDGSETPEPFA EECCCCCCCCCCCHH	40.90	25619855
240	Phosphorylation	RETDGSETPEPFAAE CCCCCCCCCCCHHHH	34.35	27087446
249	Ubiquitination	EPFAAEAKFFTESRL CCHHHHHHHHCHHHH	32.30	-
249	Acetylation	EPFAAEAKFFTESRL CCHHHHHHHHCHHHH	32.30	155673
329	Phosphorylation	RLRIWRDYVPPTANL HHHHHHHCCCCCCCC	13.29	29514104
339	Malonylation	PTANLDQKDKQFVAK CCCCCCHHHHHHHHH	67.56	26320211
339	Acetylation	PTANLDQKDKQFVAK CCCCCCHHHHHHHHH	67.56	-
341	Malonylation	ANLDQKDKQFVAKVM CCCCHHHHHHHHHHH	53.31	26320211
371	Phosphorylation	DYKTIHLSSIRPPRL CCEEEEECCCCCCCC	15.01	25159016
372	Phosphorylation	YKTIHLSSIRPPRLE CEEEEECCCCCCCCC	29.04	29514104
389	Ubiquitination	NIQDKNKKLRPLYDI CCCCCCCCCCCCCCC	60.15	-
414	Ubiquitination	RKKLIGKKVNVTVDY HHHHCCCEEEEEEEE	33.55	-
414	Malonylation	RKKLIGKKVNVTVDY HHHHCCCEEEEEEEE	33.55	26320211
418	Phosphorylation	IGKKVNVTVDYIRPA CCCEEEEEEEEECCC	11.49	25159016
421	Phosphorylation	KVNVTVDYIRPASPA EEEEEEEEECCCCCC	8.42	25159016
426	Phosphorylation	VDYIRPASPATETVP EEEECCCCCCCCCCC	20.11	27087446
429	Phosphorylation	IRPASPATETVPAFS ECCCCCCCCCCCCCC	35.26	22324799
431	Phosphorylation	PASPATETVPAFSER CCCCCCCCCCCCCCC	27.69	22942356
436	Phosphorylation	TETVPAFSERTCATV CCCCCCCCCCCEEEE	28.42	25159016
440	S-nitrosocysteine	PAFSERTCATVTIGG CCCCCCCEEEEEECC	3.61	-
440	S-nitrosylation	PAFSERTCATVTIGG CCCCCCCEEEEEECC	3.61	20925432
457	Malonylation	IAEALVSKGLATVIR HHHHHHHCCCEEEEE	50.92	26073543
491	Acetylation	ARAIKNGKGLHSKKE HHHHHCCCCCCCCCC	68.63	6568543
513	Ubiquitination	DISGDTQKAKQFLPF CCCCCHHHHHHHHHH	60.69	-
515	Ubiquitination	SGDTQKAKQFLPFLQ CCCHHHHHHHHHHHH	48.93	-
533	Phosphorylation	RSEAVVEYVFSGSRL CCHHHEEEEECCCCE	8.66	22817900
541	Malonylation	VFSGSRLKLYLPKET EECCCCEEEECCHHH	33.69	26320211
586	Acetylation	EEATLFTKELVLQRE HHHHEEEHHHHHEEE	41.54	66699287
639	Phosphorylation	FTAERSAYYKPLLSA CEECCCCCHHHHCCH	17.17	29514104
640	Phosphorylation	TAERSAYYKPLLSAE EECCCCCHHHHCCHH	13.07	29514104
641	Malonylation	AERSAYYKPLLSAEE ECCCCCHHHHCCHHH	19.26	32601280
641	Ubiquitination	AERSAYYKPLLSAEE ECCCCCHHHHCCHHH	19.26	-
641	Acetylation	AERSAYYKPLLSAEE ECCCCCHHHHCCHHH	19.26	23806337
641	Succinylation	AERSAYYKPLLSAEE ECCCCCHHHHCCHHH	19.26	23954790
645	Phosphorylation	AYYKPLLSAEEAAKQ CCHHHHCCHHHHHHH	41.12	30352176
661	Phosphorylation	KEKVWAHYEERPVEE HHHHHHHHHCCCHHH	16.25	25367039
752	Malonylation	WYRARVEKVESPAKV EEEEEEEECCCCCEE	48.74	26320211
752	Acetylation	WYRARVEKVESPAKV EEEEEEEECCCCCEE	48.74	23806337
755	Phosphorylation	ARVEKVESPAKVHVF EEEEECCCCCEEEEE	32.90	26824392
758	Malonylation	EKVESPAKVHVFYID EECCCCCEEEEEEEE	35.94	26320211
775	Phosphorylation	NREILPSTRLGTLPP CCEECCCCCCCCCCC	28.15	19367708
779	Phosphorylation	LPSTRLGTLPPAFST CCCCCCCCCCCCCCC	40.46	-
785	Phosphorylation	GTLPPAFSTRVLPAQ CCCCCCCCCCCCCCC	19.87	-
786	Phosphorylation	TLPPAFSTRVLPAQA CCCCCCCCCCCCCCC	20.53	19367708
824	Phosphorylation	VVRDIQNTQCLLNVE HHHHHHHCEEEEECH	12.32	29472430
834	Phosphorylation	LLNVEHLSASCPHVT EEECHHHHHCCCEEE	21.75	29472430
836	Phosphorylation	NVEHLSASCPHVTLQ ECHHHHHCCCEEEEE	25.46	26824392
841	Phosphorylation	SASCPHVTLQFADSK HHCCCEEEEEECCCC	16.29	29472430
847	Phosphorylation	VTLQFADSKGDVGLG EEEEECCCCCCEECE	34.80	23984901
869	Acetylation	MVEVRKEKQFQKVIT EEEECCHHHHHHHHH	60.49	2415395
873	Ubiquitination	RKEKQFQKVITEYLN CCHHHHHHHHHHHHC	36.57	-
886	Ubiquitination	LNAQESAKSARLNLW HCHHHHHHHHCCCHH	54.66	-
908	Phosphorylation	DDADEFGYSR----- CCCHHCCCCC-----	13.44	25619855
909	Phosphorylation	DADEFGYSR------ CCHHCCCCC------	31.71	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SND1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SND1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SND1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SND1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.