DUS3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUS3_MOUSE
• UniProt AC: Q9D7X3
• Protein Name: Dual specificity protein phosphatase 3
• Gene Name: Dusp3
• Organism: Mus musculus (Mouse).
• Sequence Length: 185
• Subcellular Localization: Nucleus .
• Protein Description: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity)..
• Protein Sequence: MSSSFELSVQDLNDLLSDGSGCYSLPSQPCNEVVPRVYVGNASVAQDITQLQKLGITHVLNAAEGRSFMHVNTSASFYEDSGITYLGIKANDTQEFNLSAYFERATDFIDQALAHKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSTVRQNREIGPNDGFLAQLCQLNDRLAKEGKVKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MSSSFELSVQDLNDL CCCCEEEEHHHHHHH	15.55	23649490
24	Phosphorylation	SDGSGCYSLPSQPCN CCCCCCCCCCCCCCC	37.57	23649490
53	Ubiquitination	QDITQLQKLGITHVL HHHHHHHHCCCCEEE	58.22	-
101	Phosphorylation	QEFNLSAYFERATDF CEEEHHHHHHHHHHH	11.55	28464351
124	S-nitrosocysteine	NGRVLVHCREGYSRS CCCEEEECCCCCCCC	3.10	-
124	S-nitrosylation	NGRVLVHCREGYSRS CCCEEEECCCCCCCC	3.10	21278135
131	Phosphorylation	CREGYSRSPTLVIAY CCCCCCCCHHHHHHH	19.12	26643407
133	Phosphorylation	EGYSRSPTLVIAYLM CCCCCCHHHHHHHHH	34.60	26643407
138	Phosphorylation	SPTLVIAYLMMRQKM CHHHHHHHHHHHHCC	5.52	26643407
171	S-nitrosocysteine	DGFLAQLCQLNDRLA CCHHHHHHHHHHHHH	2.62	-
171	Glutathionylation	DGFLAQLCQLNDRLA CCHHHHHHHHHHHHH	2.62	24333276
171	S-nitrosylation	DGFLAQLCQLNDRLA CCHHHHHHHHHHHHH	2.62	21278135
171	S-palmitoylation	DGFLAQLCQLNDRLA CCHHHHHHHHHHHHH	2.62	28680068

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
38	Y	Phosphorylation	Kinase	ZAP70	P43404	GPS
138	Y	Phosphorylation	Kinase	ZAP70	P43404	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DUS3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUS3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VRK3_MOUSE	Vrk3	physical	18035061
MK01_MOUSE	Mapk1	physical	18035061

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.