VRK3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VRK3_MOUSE
• UniProt AC: Q8K3G5
• Protein Name: Inactive serine/threonine-protein kinase VRK3
• Gene Name: Vrk3
• Organism: Mus musculus (Mouse).
• Sequence Length: 453
• Subcellular Localization: Nucleus .
• Protein Description: Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus..
• Protein Sequence: MISFCPVCGKSVKVSFKFCPYCGKALPVEEDGGTQSAVTPHVSSVPGSRRDLNSSFETSPKKVKCSHTVTSLPLSRHSDCDSSGSDNTLTSPDRATGTRSRPLTPKGSPLSNRQSPQTLKRTRVTTSLQALATGTELTDQNGKHWTLGALQIRDDQGILYEAEPTSAVPSESRTQKWRFSLKLDSKDGRLFNEQNFFQRVAKPLQVNKWKKQFLLPLLAIPTCIGFGIHQDKYRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYLHENEYVHGNLTAENVFVNPEDLSQVTLVGYGFTYRYCPGGKHVAYKEGSRSPHDGDLEFISMDLHKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLPNTEKITRQKQKYLDSPERLVGLCGRWNKASETLREYLKVVMALNYEEKPPYATLRNSLEALLQDMRVSPYDPLDLQMVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	PVEEDGGTQSAVTPH EEECCCCCCCCCCCC	25.53	26643407
36	Phosphorylation	EEDGGTQSAVTPHVS ECCCCCCCCCCCCCC	25.25	26643407
39	Phosphorylation	GGTQSAVTPHVSSVP CCCCCCCCCCCCCCC	13.85	26643407
43	Phosphorylation	SAVTPHVSSVPGSRR CCCCCCCCCCCCCCC	23.68	26643407
44	Phosphorylation	AVTPHVSSVPGSRRD CCCCCCCCCCCCCCC	31.10	26643407
48	Phosphorylation	HVSSVPGSRRDLNSS CCCCCCCCCCCCCCC	20.33	26643407
54	Phosphorylation	GSRRDLNSSFETSPK CCCCCCCCCCCCCCC	43.64	30635358
55	Phosphorylation	SRRDLNSSFETSPKK CCCCCCCCCCCCCCE	26.48	27149854
58	Phosphorylation	DLNSSFETSPKKVKC CCCCCCCCCCCEEEC	48.60	27149854
59	Phosphorylation	LNSSFETSPKKVKCS CCCCCCCCCCEEECC	27.76	25521595
68	Phosphorylation	KKVKCSHTVTSLPLS CEEECCEEECCCCCC	14.80	22871156
78	Phosphorylation	SLPLSRHSDCDSSGS CCCCCCCCCCCCCCC	38.53	-
82	Phosphorylation	SRHSDCDSSGSDNTL CCCCCCCCCCCCCCC	42.82	30635358
83	Phosphorylation	RHSDCDSSGSDNTLT CCCCCCCCCCCCCCC	29.12	30635358
85	Phosphorylation	SDCDSSGSDNTLTSP CCCCCCCCCCCCCCC	29.63	30635358
88	Phosphorylation	DSSGSDNTLTSPDRA CCCCCCCCCCCCCCC	36.08	30635358
90	Phosphorylation	SGSDNTLTSPDRATG CCCCCCCCCCCCCCC	35.85	30635358
91	Phosphorylation	GSDNTLTSPDRATGT CCCCCCCCCCCCCCC	28.10	28973931
96	Phosphorylation	LTSPDRATGTRSRPL CCCCCCCCCCCCCCC	39.72	30635358
98	Phosphorylation	SPDRATGTRSRPLTP CCCCCCCCCCCCCCC	22.55	30635358
100	Phosphorylation	DRATGTRSRPLTPKG CCCCCCCCCCCCCCC	37.78	23984901
104	Phosphorylation	GTRSRPLTPKGSPLS CCCCCCCCCCCCCCC	26.15	29895711
108	Phosphorylation	RPLTPKGSPLSNRQS CCCCCCCCCCCCCCC	28.88	25521595
111	Phosphorylation	TPKGSPLSNRQSPQT CCCCCCCCCCCCCHH	33.09	22324799
115	Phosphorylation	SPLSNRQSPQTLKRT CCCCCCCCCHHHHHH	18.75	27149854
118	Phosphorylation	SNRQSPQTLKRTRVT CCCCCCHHHHHHHHH	37.32	25266776
389	Phosphorylation	QKQKYLDSPERLVGL HHHHHCCCHHHHHHH	26.51	26745281
444	Phosphorylation	QDMRVSPYDPLDLQM HHCCCCCCCCCCCCC	23.76	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VRK3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VRK3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VRK3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DUS3_MOUSE	Dusp3	physical	18035061
MK01_MOUSE	Mapk1	physical	18035061

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.