NU188_MOUSE - dbPTM
NU188_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NU188_MOUSE
UniProt AC Q6ZQH8
Protein Name Nucleoporin NUP188 homolog
Gene Name Nup188
Organism Mus musculus (Mouse).
Sequence Length 1759
Subcellular Localization Nucleus, nuclear pore complex .
Protein Description May function as a component of the nuclear pore complex (NPC)..
Protein Sequence MAAAAGGPCVRSSRELWTILLGRSALRELNQIEAELNKYWQRLLEGLSYYKPPSPSSAERVKANKDVASPLKELGLRVSKFLGLDEEQSVQLLQCYLQEDYRGTRDSLKTVLQDERQSQALTLKIADYYYEERTCILRCVLHLLTYFQDERHPYRAEYADCVDKLEKELVLKYRQQFEELYRTEAPTWETHGNLMTERQVSRWLVQCLREQSMLLEIIFLYYAYFEMAPSDLLVLTKMFKEQGFGSRQTSRHLVGGTMDPFVDRIGYFSALILVEGMDIESLHKYALDDRRELHQFAQDGLICQDMDRAMLTLGDIPHHAPVLLAWALLRHTLSPEETSSVVRKIGGTAIQLNVFQYLTRLLRSLASGGNDCTTSTACMCVYGLLSFALTSLELHTLGNQQDVIDTACEVLADPSLPELFWGTEPTSGLGIILDSVCGMFPHLLSPLLQLLRALVSGKSTAKKVYSFLDKMSFYNELHKHKPHDVLSHEDGTLWRRQTPKLLYPLGGQTNLRIPQGTVGQVMLDDRAYLVRWEYSYSSWTLFTCEIEMLLHVVSTADVIQHCQRVKPIIDLVHKVISTDLSIADCLLPITSRIYMLLQRLTTVISPPVNVIASCVNCLTVLAARNPAKVWTDLRHTGFLPFVAHPVSNMTQMISAEGMNAGGYGSLLMNSEQPQGEYGVTIAFLRLVTTLVKGQLGSTQSQGLVPCVMFVLKEMLPSYHKWRYNSHGVRELIGCLILELIHAILNLCQETELHSSHTPSLPSLCICSLAYTEAGQTVISIMGIGVDTIDMVMAAQPRSDGPEGQGQGQLLIKTVKLAFSVTNNVIRLKPPSNVVSPLEQALTQHGAHGNNLIAVLAKYIYHRHDPALPRLAIQLLKRLATVAPMSVYACLGSDAAAIRDAFLTRLQSKIEDMRIKVMILEFLTVAVETQPGLIELFLNLEVKDGSNGSKEFSLGVWSCLHVVLELIDSQQQDRYWCPPLLHRAAIAFLHALWQDRRDSAMLVLRTKPKFWENLTSPLFGTLSPPSETSEPSVLETCALIMKIICLEIYYVVKGSLDQSLKDTLKKFSSEKRFAYWSGYVKSLAVYMADTEGSSCTSLLEYQMLVSAWRILLIIAASHADVMHLTDMAVRRQLFLDVLDGTKALLLVAASVNCLRLGSMMCTLLLILLRQWKRELGAVEKILGPLTEILEGVLQADQQLMEKTKAKVFSAFITVLQMKELRVGDIPQYSQLVLNVCETLQEEVIALFDQTRHSLASDSAAEDKDSMETDDCPRPRHKDQRDGVCVLGLHLAKELCEVDEDGDSWLQVTRRLPILPTLLTTLEVSLRMKQNLHFTEAALHLLLTLARTQQGATAVAGAGITQSICLPLLSVYQLSSNGTGQTPSTSRKSLDAPSWPGVYRLSMSLMERLLKTLRYNFLTEALDFVGVHQERTLQCLNAVKTVQSLACLEEADHTVGFILQLSHFRKEWHFHLPQLMRDVQVNLGYLCQACTSLLHSRKMLQHYLQNKNGDGLPSAVTPRAQRPSTTTTTTTTTTALATPAGCSSKQPTADTEASEQRALHTVQYGLLKILSRTLAALRHFTPDVCQILLDQSLDLAEYNFLFALSFTTPTFDSEVAPSFGTLLATVNVALNMLGELDKKKESLTQAVGLSTQAEGTRTLKSLLMFTMENCFYLLISQAVRYLRDPAVHPRDKQRMKQELSSELSTLLSSLSRYFRRGAPSSPAAGVLPSPQGKATSLSKASPESQEPLIQLVQAFVRHVQR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAAAGGPC
------CCCCCCCCC		19.67-
13PhosphorylationGGPCVRSSRELWTIL
CCCCCCCHHHHHHHH		21.14-
38AcetylationQIEAELNKYWQRLLE
HHHHHHHHHHHHHHH		61.5623954790
54PhosphorylationLSYYKPPSPSSAERV
HCCCCCCCCCHHHHH		46.0429514104
69PhosphorylationKANKDVASPLKELGL
HCCCCCCHHHHHHCC		30.5225159016
212PhosphorylationVQCLREQSMLLEIIF
HHHHHHHHHHHHHHH		13.47-
344UbiquitinationETSSVVRKIGGTAIQ
HHHHHHHHHCCHHHH		33.81-
470UbiquitinationKVYSFLDKMSFYNEL
HHHHHHHHHHHHHHH		38.2922790023
481UbiquitinationYNELHKHKPHDVLSH
HHHHHHCCCCCCCCC		49.1822790023
500UbiquitinationLWRRQTPKLLYPLGG
CHHCCCCCEEEECCC		55.2922790023
876UbiquitinationRLAIQLLKRLATVAP
HHHHHHHHHHHCCCC		54.6922790023
903PhosphorylationAIRDAFLTRLQSKIE
HHHHHHHHHHHHHHH		23.9126026062
907PhosphorylationAFLTRLQSKIEDMRI
HHHHHHHHHHHHHHH		39.9426026062
998PhosphorylationLWQDRRDSAMLVLRT
HHHCCCCCCEEEEEC		17.4828059163
1255PhosphorylationQTRHSLASDSAAEDK
HHCHHHHCCCHHCCH		37.0718846507
1257PhosphorylationRHSLASDSAAEDKDS
CHHHHCCCHHCCHHC		27.2125521595
1315PhosphorylationRRLPILPTLLTTLEV
CCCCCHHHHHHHHHH		30.8425777480
1318PhosphorylationPILPTLLTTLEVSLR
CCHHHHHHHHHHHHH		32.2325777480
1319PhosphorylationILPTLLTTLEVSLRM
CHHHHHHHHHHHHHH		22.3825777480
1323PhosphorylationLLTTLEVSLRMKQNL
HHHHHHHHHHHHCCC		10.8225777480
1387PhosphorylationTPSTSRKSLDAPSWP
CCCCCCCCCCCCCCC		30.3026643407
1501PhosphorylationSRKMLQHYLQNKNGD
HHHHHHHHHHCCCCC		9.3122817900
1512PhosphorylationKNGDGLPSAVTPRAQ
CCCCCCCCCCCCCCC		40.1730635358
1515PhosphorylationDGLPSAVTPRAQRPS
CCCCCCCCCCCCCCC		13.5322006019
1522PhosphorylationTPRAQRPSTTTTTTT
CCCCCCCCCCEEEEE		40.34-
1522O-linked_GlycosylationTPRAQRPSTTTTTTT
CCCCCCCCCCEEEEE		40.3430059200
1524PhosphorylationRAQRPSTTTTTTTTT
CCCCCCCCEEEEEEE		26.8725159016
1524O-linked_GlycosylationRAQRPSTTTTTTTTT
CCCCCCCCEEEEEEE		26.8730059200
1525O-linked_GlycosylationAQRPSTTTTTTTTTT
CCCCCCCEEEEEEEC		23.4130059200
1526O-linked_GlycosylationQRPSTTTTTTTTTTA
CCCCCCEEEEEEECE		21.7630059200
1527O-linked_GlycosylationRPSTTTTTTTTTTAL
CCCCCEEEEEEECEE		21.7630059200
1528O-linked_GlycosylationPSTTTTTTTTTTALA
CCCCEEEEEEECEEE		21.7630059200
1532PhosphorylationTTTTTTTTALATPAG
EEEEEEECEEECCCC		19.9925159016
1536PhosphorylationTTTTALATPAGCSSK
EEECEEECCCCCCCC		17.9625159016
1540GlutathionylationALATPAGCSSKQPTA
EEECCCCCCCCCCCC		4.5124333276
1718PhosphorylationYFRRGAPSSPAAGVL
HHHCCCCCCCCCCCC		48.7125521595
1719PhosphorylationFRRGAPSSPAAGVLP
HHCCCCCCCCCCCCC		19.9427087446
1727PhosphorylationPAAGVLPSPQGKATS
CCCCCCCCCCCCCCC		26.2027087446
1737UbiquitinationGKATSLSKASPESQE
CCCCCCCCCCHHHCH		59.1722790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1515TPhosphorylationKinaseMTORQ9JLN9
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NU188_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NU188_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NUP62_HUMANNUP62physical
20360068
NU188_HUMANNUP188physical
20360068
KPYM_HUMANPKMphysical
20360068
OGT1_HUMANOGTphysical
20360068
NUP93_HUMANNUP93physical
20360068
NUP98_HUMANNUP98physical
20360068
NUP88_HUMANNUP88physical
20360068
NU214_HUMANNUP214physical
20360068
RAE1L_HUMANRAE1physical
20360068
XPO1_HUMANXPO1physical
20360068
RAN_HUMANRANphysical
20360068
NUP88_HUMANNUP88physical
26496610
RS3_HUMANRPS3physical
26496610
RS24_HUMANRPS24physical
26496610
NU214_HUMANNUP214physical
26496610
NUP93_HUMANNUP93physical
26496610
RAD50_HUMANRAD50physical
26496610
IPO7_HUMANIPO7physical
26496610
SDF2L_HUMANSDF2L1physical
26496610
NUSAP_HUMANNUSAP1physical
26496610
FBP1L_HUMANFNBP1Lphysical
26496610
TFB2M_HUMANTFB2Mphysical
26496610
M17L2_HUMANMPV17L2physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NU188_MOUSE

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Related Literatures of Post-Translational Modification

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