M17L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M17L2_HUMAN
• UniProt AC: Q567V2
• Protein Name: Mpv17-like protein 2
• Gene Name: MPV17L2
• Organism: Homo sapiens (Human).
• Sequence Length: 206
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Mitochondrion inner membrane .
• Protein Description: Required for the assembly and stability of the mitochondrial ribosome. [PubMed: 24948607 Is a positive regulator of mitochondrial protein synthesis]
• Protein Sequence: MARGGWRRLRRLLSAGQLLFQGRALLVTNTLGCGALMAAGDGVRQSWEIRARPGQVFDPRRSASMFAVGCSMGPFLHYWYLSLDRLFPASGLRGFPNVLKKVLVDQLVASPLLGVWYFLGLGCLEGQTVGESCQELREKFWEFYKADWCVWPAAQFVNFLFVPPQFRVTYINGLTLGWDTYLSYLKYRSPVPLTPPGCVALDTRAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	RRLRRLLSAGQLLFQ HHHHHHHHHHCHHHC	34.64	28122231
46	Phosphorylation	AGDGVRQSWEIRARP CCCCCHHEEEEECCC	18.99	24719451
187	Phosphorylation	TYLSYLKYRSPVPLT HHHHHHCCCCCCCCC	17.46	17924679
189	Phosphorylation	LSYLKYRSPVPLTPP HHHHCCCCCCCCCCC	27.45	28258704
194	Phosphorylation	YRSPVPLTPPGCVAL CCCCCCCCCCCCEEE	22.74	-
203	Phosphorylation	PGCVALDTRAD---- CCCEEEECCCC----	28.71	17924679

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of M17L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M17L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M17L2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of M17L2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-187; SER-189 ANDTHR-203, AND MASS SPECTROMETRY.
PubMed: 17924679