MIC60_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIC60_MOUSE
• UniProt AC: Q8CAQ8
• Protein Name: MICOS complex subunit Mic60
• Gene Name: Immt
• Organism: Mus musculus (Mouse).
• Sequence Length: 757
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein . Mitochondrion .
• Protein Description: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology..
• Protein Sequence: MLRACQLSGVTVAAQSCLCGKFVLRPLRPCRRYSTSSSSGLTAGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPLPKKPVQSGPLKISSVSEVMKDSKLPVAQSQKTKGDTPASAASTGAAQIISAAGDTLSVPAPAVQHEDTIKTECPNTNEGKSTSETTEEAFSSSVRERPPEEVAARLAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQLKPPAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASAVGIGTTQVQQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	PLRPCRRYSTSSSSG ECCCCCCCCCCCCCC		23737553
34	Phosphorylation	LRPCRRYSTSSSSGL CCCCCCCCCCCCCCC		27742792
35	Phosphorylation	RPCRRYSTSSSSGLT CCCCCCCCCCCCCCC		27742792
36	Phosphorylation	PCRRYSTSSSSGLTA CCCCCCCCCCCCCCH		27742792
37	Phosphorylation	CRRYSTSSSSGLTAG CCCCCCCCCCCCCHH		27742792
38	Phosphorylation	RRYSTSSSSGLTAGK CCCCCCCCCCCCHHH		27742792
39	Phosphorylation	RYSTSSSSGLTAGKI CCCCCCCCCCCHHHC		26643407
42	Phosphorylation	TSSSSGLTAGKIAGA CCCCCCCCHHHCCCC		29472430
77	Malonylation	HFRESVEKTIPYSDK HHHHHHHHHCCCHHH		26320211
92	Phosphorylation	LFGMVLGSAPYTVPL HHCHHCCCCCCEECC		23140645
95	Phosphorylation	MVLGSAPYTVPLPKK HHCCCCCCEECCCCC		23140645
96	Phosphorylation	VLGSAPYTVPLPKKP HCCCCCCEECCCCCC		23140645
102	Malonylation	YTVPLPKKPVQSGPL CEECCCCCCCCCCCC		26320211
106	Phosphorylation	LPKKPVQSGPLKISS CCCCCCCCCCCEECC		30352176
110	Malonylation	PVQSGPLKISSVSEV CCCCCCCEECCHHHH		26320211
112	Phosphorylation	QSGPLKISSVSEVMK CCCCCEECCHHHHHC		25521595
113	Phosphorylation	SGPLKISSVSEVMKD CCCCEECCHHHHHCC		25521595
115	Phosphorylation	PLKISSVSEVMKDSK CCEECCHHHHHCCCC		26643407
119	Malonylation	SSVSEVMKDSKLPVA CCHHHHHCCCCCCCC		26320211
121	Phosphorylation	VSEVMKDSKLPVAQS HHHHHCCCCCCCCCC		-
122	Malonylation	SEVMKDSKLPVAQSQ HHHHCCCCCCCCCCC		26320211
128	Phosphorylation	SKLPVAQSQKTKGDT CCCCCCCCCCCCCCC		25521595
128 (in isoform 2)	Phosphorylation	-		25266776
128 (in isoform 3)	Phosphorylation	-		25266776
128 (in isoform 4)	Phosphorylation	-		25266776
130	Acetylation	LPVAQSQKTKGDTPA CCCCCCCCCCCCCCC		23806337
130	Malonylation	LPVAQSQKTKGDTPA CCCCCCCCCCCCCCC		26320211
130	Succinylation	LPVAQSQKTKGDTPA CCCCCCCCCCCCCCC		23806337
169 (in isoform 3)	Phosphorylation	-		25521595
171 (in isoform 3)	Phosphorylation	-		25195567
180	Phosphorylation	PNTNEGKSTSETTEE CCCCCCCCCCHHHHH		28066266
181	Phosphorylation	NTNEGKSTSETTEEA CCCCCCCCCHHHHHH		28066266
182	Phosphorylation	TNEGKSTSETTEEAF CCCCCCCCHHHHHHH		28066266
184	Phosphorylation	EGKSTSETTEEAFSS CCCCCCHHHHHHHHH		30635358
185	Phosphorylation	GKSTSETTEEAFSSS CCCCCHHHHHHHHHH		30635358
189 (in isoform 3)	Phosphorylation	-		28464351
190	Phosphorylation	ETTEEAFSSSVRERP HHHHHHHHHHHHHCC		29176673
191	Phosphorylation	TTEEAFSSSVRERPP HHHHHHHHHHHHCCH		29176673
192	Phosphorylation	TEEAFSSSVRERPPE HHHHHHHHHHHCCHH		29176673
210	Acetylation	ARLAQQEKQEQVEME HHHHHHHHHHHHHHH		22902405
221	Acetylation	VEMESLAKSLEDALN HHHHHHHHHHHHHHH		-
222	Phosphorylation	EMESLAKSLEDALNR HHHHHHHHHHHHHHH		23737553
230	Phosphorylation	LEDALNRTSSVTLQT HHHHHHHCCCCCHHH		26643407
231	Phosphorylation	EDALNRTSSVTLQTI HHHHHHCCCCCHHHH		26643407
232	Phosphorylation	DALNRTSSVTLQTIT HHHHHCCCCCHHHHH		26643407
234	Phosphorylation	LNRTSSVTLQTITAQ HHHCCCCCHHHHHHC		26643407
237	Phosphorylation	TSSVTLQTITAQNAA CCCCCHHHHHHCHHH		29899451
252	Phosphorylation	VQAVKAHSNILKTAM HHHHHHCCCHHHHHH		20047950
256	Acetylation	KAHSNILKTAMDNSE HHCCCHHHHHHHCCC		22826441
257 (in isoform 2)	Acetylation	-		-
257 (in isoform 2)	Ubiquitination	-		-
262	Phosphorylation	LKTAMDNSEIAGEKK HHHHHHCCCCCCCCC		25521595
268	Acetylation	NSEIAGEKKSAQWRT CCCCCCCCCCHHHHH		23201123
268	Succinylation	NSEIAGEKKSAQWRT CCCCCCCCCCHHHHH		26388266
268	Ubiquitination	NSEIAGEKKSAQWRT CCCCCCCCCCHHHHH		-
268 (in isoform 2)	Ubiquitination	-		22790023
270	Phosphorylation	EIAGEKKSAQWRTVE CCCCCCCCHHHHHHH		22210690
270 (in isoform 2)	Acetylation	-		-
281	Acetylation	RTVEGALKERRKAVD HHHHHHHHHHHHHHH		23864654
281	Malonylation	RTVEGALKERRKAVD HHHHHHHHHHHHHHH		26320211
281	Succinylation	RTVEGALKERRKAVD HHHHHHHHHHHHHHH		23954790
285	Acetylation	GALKERRKAVDEAAD HHHHHHHHHHHHHHH		23954790
285	Malonylation	GALKERRKAVDEAAD HHHHHHHHHHHHHHH		26320211
287 (in isoform 2)	Acetylation	-		-
296	Acetylation	EAADALLKAKEELEK HHHHHHHHHHHHHHH		23864654
298	Acetylation	ADALLKAKEELEKMK HHHHHHHHHHHHHHH		23864654
298	Succinylation	ADALLKAKEELEKMK HHHHHHHHHHHHHHH		23954790
305	Acetylation	KEELEKMKTIIEDAK HHHHHHHHHHHHHHH		23864654
305	Malonylation	KEELEKMKTIIEDAK HHHHHHHHHHHHHHH		26320211
312	Succinylation	KTIIEDAKKREIAGA HHHHHHHHHHHHCCC		23954790
320	Phosphorylation	KREIAGATPHITAAE HHHHCCCCCCEECCC		23737553
348 (in isoform 3)	Phosphorylation	-		26060331
349	Phosphorylation	KKVQAAQSEAKVVSQ HHHHHHHHHHHHHHH		23684622
349 (in isoform 3)	Phosphorylation	-		28464351
352	Malonylation	QAAQSEAKVVSQYHE HHHHHHHHHHHHHHH		26320211
355	Phosphorylation	QSEAKVVSQYHELVV HHHHHHHHHHHHHHH		19060867
357	Phosphorylation	EAKVVSQYHELVVQA HHHHHHHHHHHHHHC		29899451
374	Phosphorylation	DFRKELDSITPDITP HHHHHHHHCCCCCCC		28066266
376	Phosphorylation	RKELDSITPDITPGW HHHHHHCCCCCCCCC		28066266
380	Phosphorylation	DSITPDITPGWKGMS HHCCCCCCCCCCCCC		28066266
387	Phosphorylation	TPGWKGMSISDLAGK CCCCCCCCHHHHCCC		25521595
389	Phosphorylation	GWKGMSISDLAGKLS CCCCCCHHHHCCCCC		23737553
396	Phosphorylation	SDLAGKLSTDDLNSL HHHCCCCCHHHHHHH		26370283
397	Phosphorylation	DLAGKLSTDDLNSLI HHCCCCCHHHHHHHH		29899451
402	Phosphorylation	LSTDDLNSLIAHAHR CCHHHHHHHHHHHHH		-
415 (in isoform 2)	Acetylation	-		-
424 (in isoform 2)	Acetylation	-		-
426	Acetylation	AQQKATEKQHIELAL HHHHHHHHHHHHHHH		23201123
426	Malonylation	AQQKATEKQHIELAL HHHHHHHHHHHHHHH		26320211
426 (in isoform 2)	Acetylation	-		-
435	Acetylation	HIELALEKHKLEEKR HHHHHHHHHCHHHHH		23864654
437	Acetylation	ELALEKHKLEEKRTF HHHHHHHCHHHHHCH		23864654
443	Phosphorylation	HKLEEKRTFDSAVAK HCHHHHHCHHHHHHH		23737553
446	Phosphorylation	EEKRTFDSAVAKALE HHHHCHHHHHHHHHH		23737553
450	Acetylation	TFDSAVAKALEHHRS CHHHHHHHHHHHHHH		24062335
450	Malonylation	TFDSAVAKALEHHRS CHHHHHHHHHHHHHH		25418362
457	Phosphorylation	KALEHHRSEIQAEQD HHHHHHHHHHHHHHH		27742792
494 (in isoform 2)	Acetylation	-		-
498	Acetylation	DHLRDVLKVQEQELK HHHHHHHHHHHHHHH		23954790
498	Malonylation	DHLRDVLKVQEQELK HHHHHHHHHHHHHHH		26320211
504 (in isoform 2)	Ubiquitination	-		-
505	Acetylation	KVQEQELKYEFEQGL HHHHHHHHHHHHHHH		23864654
505	Succinylation	KVQEQELKYEFEQGL HHHHHHHHHHHHHHH		23954790
506	Phosphorylation	VQEQELKYEFEQGLS HHHHHHHHHHHHHHC		16141072
515	Acetylation	FEQGLSEKLSEQELE HHHHHCHHCCHHHHH		23954790
515	Ubiquitination	FEQGLSEKLSEQELE HHHHHCHHCCHHHHH		22790023
515 (in isoform 2)	Ubiquitination	-		22790023
554	Phosphorylation	GIEQAVQSHAVAEEE CHHHHHHHCCCCHHH		30165576
564	Acetylation	VAEEEARKAHQLWLS CCHHHHHHHHHHHHH		24062335
593	Phosphorylation	MPTIPLGSAVEAIRV CCCCCCCCHHEEEEE		28464351
625	Phosphorylation	ESLTRGVYSEETLRA HHHCCCCCCHHHHHH		20415495
626	Phosphorylation	SLTRGVYSEETLRAR HHCCCCCCHHHHHHH		28464351
635	Phosphorylation	ETLRARFYAVQKLAR HHHHHHHHHHHHHHH		-
639	Acetylation	ARFYAVQKLARRVAM HHHHHHHHHHHHHHC		23864654
639	Malonylation	ARFYAVQKLARRVAM HHHHHHHHHHHHHHC		26320211
663 (in isoform 2)	Acetylation	-		-
674	Acetylation	LFPPKQLKPPAELYP CCCHHHCCCCHHHCC		23864654
674	Succinylation	LFPPKQLKPPAELYP CCCHHHCCCCHHHCC		23954790
713	Acetylation	AKFVNQLKGESRRVA HHHHHHHCCCHHHHH		22902405
713	Malonylation	AKFVNQLKGESRRVA HHHHHHHCCCHHHHH		26320211
713	Succinylation	AKFVNQLKGESRRVA HHHHHHHCCCHHHHH		23954790
725	Acetylation	RVAQDWLKEARMTLE HHHHHHHHHHHHHHC		22902405
780 (in isoform 5)	Phosphorylation	-		22871156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIC60_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIC60_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIC60_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BUB1B_HUMAN	BUB1B	physical	26496610
DECR_HUMAN	DECR1	physical	26496610
METK2_HUMAN	MAT2A	physical	26496610
PCM1_HUMAN	PCM1	physical	26496610
PSA5_HUMAN	PSMA5	physical	26496610
RAN_HUMAN	RAN	physical	26496610
ARK72_HUMAN	AKR7A2	physical	26496610
BCL7B_HUMAN	BCL7B	physical	26496610
GOSR1_HUMAN	GOSR1	physical	26496610
TALD3_HUMAN	KIAA0586	physical	26496610
EXOC3_HUMAN	EXOC3	physical	26496610
ANKL2_HUMAN	ANKLE2	physical	26496610
TNPO3_HUMAN	TNPO3	physical	26496610
DBR1_HUMAN	DBR1	physical	26496610
FXL19_HUMAN	FBXL19	physical	26496610
C2D1A_HUMAN	CC2D1A	physical	26496610
DHTK1_HUMAN	DHTKD1	physical	26496610
RBNS5_HUMAN	RBSN	physical	26496610
C99L2_HUMAN	CD99L2	physical	26496610
TBA1C_HUMAN	TUBA1C	physical	26496610
ZN616_HUMAN	ZNF616	physical	26496610
TCAM1_HUMAN	TICAM1	physical	26496610
RICTR_HUMAN	RICTOR	physical	26496610
LAMA1_HUMAN	LAMA1	physical	26496610
K0754_HUMAN	KIAA0754	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.